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Metronidazole tablet and preparation method thereof

A technology for metronidazole tablets and plain tablets, which can be used in pill delivery, pharmaceutical formulations, antifungal agents, etc. It can solve the problems of brittleness, lack of brittleness, negative effects, etc., and improve the hardness of preparations, controllable quality, and tolerance strong effect

Inactive Publication Date: 2018-08-21
南京双科医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, most metronidazole tablets made in China lack hardness and brittleness, which will have a negative impact on the later coating process.

Method used

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  • Metronidazole tablet and preparation method thereof
  • Metronidazole tablet and preparation method thereof

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Effect test

Embodiment 1

[0025] The invention provides a metronidazole tablet, comprising plain tablet and film coating, wherein the plain tablet used comprises the following raw materials in parts by weight: metronidazole 50wt%-60wt%, filler 20wt%-50wt% , binder 2wt%-20wt%, lubricant 0.1wt%-0.4wt%, described filler is made of cornstarch and calcium hydrogen phosphate, and described binder is made of povidone K30 or povidone K30 and Made from corn starch, the lubricant is made from magnesium stearate, wherein the film coating used includes the following raw materials in parts by weight: hypromellose 83wt%-84wt% and polyethylene glycol 16wt%- 17wt%, the weight ratio of the plain tablet and film coating is 2wt%-5wt%;

[0026] The present invention also provides a kind of preparation method of metronidazole tablet, described comprises the following concrete steps:

[0027] Step 1: Making soft materials, (1) preparing adhesives, completely dissolving povidone K30 in purified water; (2) putting pretreated...

Embodiment 2

[0035] The invention provides a metronidazole tablet, comprising plain tablet and film coating, wherein the plain tablet used comprises the following raw materials in parts by weight: metronidazole 50wt%-60wt%, filler 20wt%-50wt% , binder 2wt%-20wt%, lubricant 0.1wt%-0.4wt%, described filler is made of cornstarch and calcium hydrogen phosphate, and described binder is made of povidone K30 or povidone K30 and Made from corn starch, the lubricant is made from magnesium stearate, wherein the film coating used includes the following raw materials in parts by weight: hypromellose 83wt%-84wt% and polyethylene glycol 16wt%- 17wt%, the weight ratio of the plain tablet and film coating is 2wt%-5wt%;

[0036] The present invention also provides a kind of preparation method of metronidazole tablet, described comprises the following concrete steps:

[0037] Step 1: Making soft materials, (1) preparing adhesives, completely dissolving povidone K30 in purified water; (2) putting pretreated...

Embodiment 3

[0045] The invention provides a metronidazole tablet, comprising plain tablet and film coating, wherein the plain tablet used comprises the following raw materials in parts by weight: metronidazole 50wt%-60wt%, filler 20wt%-50wt% , binder 2wt%-20wt%, lubricant 0.1wt%-0.4wt%, described filler is made of cornstarch and calcium hydrogen phosphate, and described binder is made of povidone K30 or povidone K30 and Made from corn starch, the lubricant is made from magnesium stearate, wherein the film coating used includes the following raw materials in parts by weight: hypromellose 83wt%-84wt% and polyethylene glycol 16wt%- 17wt%, the weight ratio of the plain tablet and film coating is 2wt%-5wt%;

[0046] The present invention also provides a kind of preparation method of metronidazole tablet, described comprises the following specific steps:

[0047] Step 1: making soft material, (1) prepare adhesive, completely dissolve povidone K30 in purified water; (2) put pretreated and weigh...

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Abstract

The invention discloses a metronidazole tablet. The metronidazole tablet comprises a plain tablet and a film coating, wherein the used plain tablet comprises the following raw materials in parts by weight: 50 to 60 percent of metronidazole, 20 to 50 percent of a filling agent, 2 to 20 percent of an adhesive and 0.1 to 0.4 percent of a lubricant; the used film coating comprises the following raw materials in percent by weight: 83 to 84 percent of hydroxypropyl methylcellulose and 16 to 17 percent of polyethylene glycol. Through the preparation method of the preparation, a wet granulation process is adopted, povidone K30 or corn starch serves as an adhesive, corn serves as starch, calcium hydrophosphate serves as the filling agent, magnesium stearate serves as the lubricant, and the hydroxypropyl methylcellulose serves as a coating material, so that the hardness, friability and in-vitro release of the preparation are improved, the metronidazole tablet has high hardness, the tablet is smooth and has high friability, the tolerance of the coating process is high, the prepared metronidazole tablet has in-vitro release consistent with that of metronidazole Spanish original research, the rapid release condition is met, the metronidazole tablet has equal curative effect, and the whole preparation method is simple to operate, controllable in quality and suitable for industrialized production.

Description

technical field [0001] The invention relates to the field of metronidazole tablets and a preparation method thereof, in particular to a metronidazole tablet and a preparation method thereof. Background technique [0002] At present, most metronidazole tablets made in China lack hardness and brittleness, which will have a negative impact on the later coating process. The invention solves the problem of poor tablet hardness at present, and can meet the rapid dissolution condition consistent with the original research. [0003] Therefore, it is necessary to invent a kind of metronidazole tablet and preparation method thereof to solve the above problems. Contents of the invention [0004] The object of the present invention is to provide a kind of metronidazole tablet and preparation method thereof, adopt wet granulation process by this preparation preparation method, take povidone K30 or cornstarch as binding agent, with cornstarch, calcium hydrogen phosphate as Filler, mag...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K31/4164A61K47/32A61K47/36A61K47/02A61K47/12A61P31/10
CPCA61K9/2009A61K9/2013A61K9/2027A61K9/2059A61K9/2866A61K31/4164A61P31/10
Inventor 陈红
Owner 南京双科医药开发有限公司
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