Attachment reconstructive artificial rotator cuff patch and manufacture method thereof

Abstract

Provided is an attachment reconstructive artificial rotator cuff patch and a manufacture method thereof. The method comprises the following steps that a patch intermediate layer with a nanofiber structure is constructed through electrostatic spinning, or a patch intermediate layer with a meshy fabric body structure is constructed by weaving, and the patch intermediate layer with a nanofiber structure or the patch intermediate layer with the meshy fabric body structure serves as a supporting body of the whole patch; the two ends of the patch intermediate layer are respectively a muscle tendon part and an attachment part, a patch muscle tendon part intermediate layer wraps and crosslinks on the muscle tendon part of the patch intermediate layer, and a patch attachment part intermediate layerwraps and crosslinks on the attachment part of the patch intermediate layer; the upper surfaces of the patch muscle tendon part intermediate layer and patch attachment part intermediate layer are correspondingly coated and crosslinked with patch upper layers, and the lower surfaces of the patch muscle tendon part intermediate layer and patch attachment part intermediate layer are correspondinglycoated and crosslinked with patch muscle tendon part lower layers and patch attachment part lower layers to form the whole attachment reconstructive artificial rotator cuff patch. The provided rotatorcuff patch can repair rotator cuff coloboma and reconstruct tendon-bone attachment, and has good mechanical strength and good biocompatibility.

Description

technical field [0001] The invention relates to the technical field of surgical patches, in particular to an insertion reconstruction type artificial rotator cuff patch and a manufacturing method thereof. Background technique [0002] Rotator cuff injury is one of the common orthopedic diseases, and it is a common cause of shoulder joint pain, limited mobility, and functional impairment. The incidence rate gradually increases with age. For patients who fail conservative treatment and patients with large rotator cuff injuries, surgery is usually required to repair the torn rotator cuff, so as to relieve pain and restore shoulder joint function, but the postoperative effect is not ideal, and the failure rate of revision is 20% to 70%. This is related to the extent of rotator cuff tear, tendon contracture, fat infiltration, inappropriate postoperative rehabilitation exercises and other factors, but the difficulty of postoperative tendon-bone interface healing is the main reason...

AI Technical Summary

Problems solved by technology

The autograft materials are mainly derived from the fascia lata and the long head tendon of the biceps brachii, etc. The biggest advantage is that it has good biocompatibility, but it will cause additional trauma when the materials are taken, resulting in damage to the donor site.

Allogeneic tissue graft materials are usually derived from allogeneic rotator cuff, tibialis anterior tendon, patellar tendon, Achilles tendon, etc. Although the postoperative range of motion and muscle strength of the shoulder joint are significantly improved, they lack stable mechanical strength and are prone to failure after transplantation. Immune rejection, risk of infection, and limited sources

Decellularized tissue grafts mainly include xenogeneic tissue transplantation and allogeneic tissue transplantation, such as animal dermis, small intestine, pericardium, etc., using inherent collagen, non-collagen, and three-dimensional structures as scaffolds to promote postoperative collagen fibers and Angiogenesis and functional reconstruction of the tendon-bone interface have good biocompatibility and ductility, but their mechanical strength cannot meet the mechanical load strength of the rotator cuff

[0006] Current rotator cuff patch materials are limited in clinical application due to factors such as histocompatibility, biomechanical strength, tissue source, and safety.

In addition, all rotator cuff patches are unable to reconstruct the tendon-bone insertion from the four layers of tendon, fibrocartilage, mineralized cartilage and bone tissue, so the design can reconstruct the tendon-bone insertion, mechanical strength Excellent and biocompatible rotator cuff patch has important clinical application value for the treatment of rotator cuff injuries

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