Novel biodegradation nerve conduit and preparation technology thereof

Abstract

The invention provides a preparation method of a nerve conduit stent. The method comprises the following steps that materials are dissolved in a polar solvent to obtain a dissolution solution; the materials are selected one or several materials from polylactic acid-polyglycolic acid copolymers, polyethylene carbonate, polylactic acid and polyglycolic acid; the dissolution solution is coated or flatly paved on a mold to obtain a mold with the dissolution solution; the mold with the dissolution solution is put into water to obtain a tubular stent. The materials such as biodegradable polylactic acid-polyglycolic acid copolymers PLGA, polypropylene carbonate PPC and the like are used; a nerve conduit is prepared by a simple and easy-to-operate solution replacement method; high support intensity and tensile strength are realized; feasible microenvironment can be provided for the nerve regeneration; the pore connectivity is high; the exchange transportation of nutrient substances and metabolic wastes is facilitated; the biocompatibility is good; the adhesion growth of nerve cells and neurogliocytes is facilitated; the nerve regeneration is promoted; the complete degradation is realized;no side effect is generated on the body.

Description

technical field [0001] The invention relates to the technical field of neurosurgery, in particular to a preparation method of a nerve guide bracket. Background technique [0002] More than 1 million people around the world experience peripheral nerve damage every year, mostly caused by transverse injuries, burns or degenerative diseases. The peripheral nervous system (PNS) is inherently capable of repair and regeneration. Its regenerative ability is related to the age of the patient, the mechanism of injury, especially the distance between the injury site and the nerve cell body. Distal nerve damage results in loss of sensation at the fingertips but can be repaired well, whereas avulsion of the proximal brachial plexus severely impairs hand sensory function, motor function, and is often accompanied by pain and chills. These injuries have seriously affected the normal life and work of patients. Small nerve defects can be automatically repaired through the inherent nerve re...

AI Technical Summary

Problems solved by technology

[0005] The nerve conduits commonly used in the prior art mostly use biodegradable materials, and are prepared by methods such as injection molding, physical rolling, cross-linking, braiding, and electrospinning. These methods require many steps and are not suitable operation, and often due to the lack of three-dimensional structure support inside the catheter due to the weak mechanical strength of the membrane, the catheter is easy to collapse and cannot play a good role in guiding the new nerve fibers by the nerve guide

However, although the nerve conduit made of non-degradable materials has scalability and good biomechanical properties, it is non-degradable and impermeable. After nerve regeneration, this material remains in the body, causing severe immune rejection. The reaction and the formation of tissue scars restrict the growth of nerves, requiring a second operation to remove them.

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