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Coenzyme Q10 preparation with auxiliary treatment effect on male oligoasthenozoospermia and preparation method thereof

A technology of preparation and coenzyme, which is applied in the field of coenzyme Q10 preparation and its preparation, can solve the problems that the amount of oral administration and absorption of consumers is not proportional, the spermatogenic function of the reproductive system cannot be enhanced, and the absorption rate and utilization rate are low, so as to improve biological Utilization, not easily affected by temperature and light, simple steps

Active Publication Date: 2018-08-10
SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, among the people who take coenzyme Q10, a certain proportion of them are for the purpose of tonifying the kidney and replenishing essence, but because coenzyme Q10 can only remove active oxygen in the reproductive system, but cannot enhance the spermatogenic function of the reproductive system, the curative effect is not significant ;In addition, the existing products of coenzyme Q10 mostly use a variety of pharmaceutical ingredients and chemical additives for production, and the interaction of various chemical additives affects the absorption of the human body, resulting in a disproportionate amount of oral intake and absorption by consumers, and the absorption of coenzyme Q10 products in the human body Both rate and utilization are low

Method used

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  • Coenzyme Q10 preparation with auxiliary treatment effect on male oligoasthenozoospermia and preparation method thereof
  • Coenzyme Q10 preparation with auxiliary treatment effect on male oligoasthenozoospermia and preparation method thereof
  • Coenzyme Q10 preparation with auxiliary treatment effect on male oligoasthenozoospermia and preparation method thereof

Examples

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Effect test

Embodiment approach

[0032] According to a preferred embodiment of the present invention, the oil is an oil with a high human absorption rate, preferably selected from coconut oil, rice bran oil, soybean oil, corn oil, peanut oil, olive oil, sesame oil or linseed oil. one or more species.

[0033] In the present invention, since coenzyme Q10 is insoluble in water, it needs to be dissolved in oil for reconciliation, so as to promote the dissolution and dispersion of coenzyme Q10.

[0034] In a further preferred embodiment, the oil is selected from one or more of coconut oil, rice bran oil, soybean oil, corn oil or linseed oil.

[0035] In a further preferred embodiment, the oil is selected from one or more of coconut oil, rice bran oil or linseed oil.

[0036] The inventor found through research that the natural functional oil coconut oil can be quickly digested in the body, is not easy to be deposited as fat in the tissue, and has various effects such as antiviral and antibacterial, and promotes ...

Embodiment 1

[0130] (1) The raw materials of the coenzyme Q10 preparation in this example include the following components by weight:

[0131]

[0132]

[0133] (2) Preparation method

[0134] (1) Weigh 3kg of Cuscuta, 3kg of Cornus officinalis, 4kg of Morinda officinalis, 2kg of Ophiopogon japonicus and 5kg of Astragalus membranaceus, mix and crush, add 80 liters of water to soak for 30 minutes, decoct, filter, and prepare the liquid medicine; add 60 liters of water to the dregs Carry out decoction, filter, and prepare the medicinal liquid; repeat the above operation once; combine the medicinal liquid decocted three times, and then decoct again, so that the medicinal liquid is concentrated to a water content of 20%, and a thick extract is obtained; Add 10% mannitol to the thick extract as a protective agent, pre-freeze at -50°C for 10h in a freeze dryer (ALPHA1-4, CHRIST, Germany), then dry at -40°C for 14h by vacuum sublimation at a low temperature, and finally Vacuum analytical d...

Embodiment 2

[0144] The method used in this example is similar to Example 1, the only difference is that the oil includes leaf oil and rice bran oil, and the addition amounts of the coconut oil and rice bran oil are 200g and 100g respectively.

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Abstract

The invention discloses a coenzyme Q10 preparation with an auxiliary treatment effect on male oligoasthenozoospermia as well as a preparation method and application thereof, wherein the coenzyme Q10 preparation is mainly prepared from the following raw materials of coenzyme Q10, sugar, grease, anti-oxidizing agents and emulsifiers; natural anti-oxidizing agents are used as raw materials for preparing the coenzyme Q10 preparation; the adverse influence of chemical additives on the human body is reduced; the bioavailability of the coenzyme Q10 is improved; the active traditional Chinese medicineingredients with the effects of nourishing the kidney, strengthening the essence, invigorating qi and promoting blood circulation are added into the coenzyme Q10 preparation; the cooperative and synergistic action is achieved with the coenzyme Q10; the effect of treating the male oligoasthenozoospermia is effectively improved. The coenzyme Q10 preparation provided by the invention has the advantages that the ingredient matching is balanced; the raw materials are simple and can be easily obtained; the finished product quality is stable; the bioavailability is high.

Description

technical field [0001] The invention belongs to the technical field of medicines and health care products, and in particular relates to a coenzyme Q10 preparation for the auxiliary treatment of male oligoasthenospermia and a preparation method thereof. Background technique [0002] Coenzyme Q is a fat-soluble quinone compound that exists in nature. Its structure is similar to vitamin K, vitamin E and plastoquinone. It is one of the important components of mitochondria in animal and plant cells. Hydrogen body, which enables cells to produce natural antioxidants and cell metabolism activators. All kinds of organisms contain a unique coenzyme Q, and what exists in the human body is coenzyme Q10. [0003] Coenzyme Q10 (CoQ10), also known as "ubiquinone", is a yellow or orange-yellow crystalline powder at room temperature, sensitive to light and heat, easily soluble in ethanol and oil-phase solvents, and exists in every cell in the human body. It is an indispensable and necessa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P15/08A61K31/122
CPCA61K31/122A61K36/39A61K36/40A61K36/43A61K36/481A61K36/746A61K36/8968A61P15/08A61K2300/00
Inventor 傅苗青周白水巩绪彦邱林
Owner SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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