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Mass spectrum system used for detecting biomolecules

A technology of intelligent spectrum and data acquisition system, applied in the field of intelligent mass spectrometry system, can solve problems such as difficulty in solving individual needs, lengthy and cumbersome detection process, etc.

Active Publication Date: 2018-08-03
BIOYONG TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, according to the relevance of these test data and related fields, technical personnel in this field (such as doctors, inspection and quarantine personnel, etc.) are required to make comprehensive judgments based on professional knowledge and combined with other information. Only personnel (such as experimenters and doctors) can complete the detection and related improvement, which is difficult to solve the contradiction between the current growing individual needs and the lengthy and cumbersome detection process and insufficient manpower

Method used

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  • Mass spectrum system used for detecting biomolecules
  • Mass spectrum system used for detecting biomolecules
  • Mass spectrum system used for detecting biomolecules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1: Preparation of Intelligent Mass Spectrometry System

[0070] The intelligent mass spectrometry system includes a mass spectrometer data acquisition system 1, an intelligent fuzzy expert system 2, a knowledge base acquisition system 3, a model acquisition system 4 and a human-computer interaction system 5, among which,

[0071] The mass spectrometer data acquisition system 1 includes a mass spectrometry device 101, a mass spectrometry data management device 102, and a mass spectrometry database storage device 103 for samples. For the mass spectrum data of the analyte, the data management device 102 also accepts the detection result mass spectrum model sent by the decision model building device 203, and transmits the final result represented by the model to the user and the storage device 103 for storage. On the basis of the instrument, an improved high-speed acquisition card, motion control card and laser attenuation card are used. The high-speed acquisition c...

Embodiment 2

[0076] Example 2: Detection of dental caries characteristic protein by intelligent spectrum method

[0077] (1) Establishment of mass spectrometry model of dental caries characteristic protein by intelligent spectrum method

[0078] 1. Samples and instruments:

[0079] The saliva samples were selected from 29 cases, 14 of which were from patients with dental caries, and the other 15 were from healthy people. The patients with dental caries were all confirmed by pathological reports. All saliva samples were taken in the morning on an empty stomach before eating, and the saliva was separated and stored in a ‐80 low-temperature refrigerator.

[0080] Matrix-assisted laser desorption time-of-flight mass spectrometry MALTI TOF MS was selected, and the WCX magnetic bead kit used in the experiment was developed by the applicant Bioyong Company. The data analysis software Bioexplorer of Bioyong Company was used to preprocess the data, and the processed data was processed by the gene...

Embodiment 3

[0107] Example 3: Diagnosis of early esophageal cancer by intelligent spectrum method

[0108] (1) Establishment of mass spectrometry model of characteristic proteins of early esophageal cancer by intelligent spectrum method

[0109] 1. Samples and instruments

[0110] Serum samples were selected from 62 cases, of which 28 were from patients with esophageal cancer and the other 34 were from healthy people. All patients with esophageal cancer were confirmed by pathological reports. All serum samples were drawn in the morning on an empty stomach before eating, and the serum was separated and stored in a ‐80 low-temperature refrigerator.

[0111] The matrix-assisted laser desorption time-of-flight mass spectrometer CLIN-TOF and the weak cation-exchange magnetic bead kit used in the experiment were developed by Beijing Bioyong Company (the applicant). The data analysis software Bioexplorer of Bioyong Company was used to preprocess the data, and the processed data was processed b...

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Abstract

The invention provides a mass spectrum system used for detecting biomolecules. The system comprises a mass spectrometer data collecting system, an intelligent fuzzy expert system, a knowledge base collecting system and a model collecting system. The mass spectrometer data collecting system is used for detecting mass spectrum data of a sample; the intelligent fuzzy expert system can carry out intelligent analysis on the mass spectrometer data; the knowledge base collecting system can store and manage related knowledge of mass spectrum detection in advance through a cloud center; the model collecting system is used for sending the known mass spectrum model data to a knowledge management system and a mass spectrum model storage device according to instructions. The system is supported by cloud center calculation, intelligent learning and storage are performed through the knowledge base collecting system, the intelligent analysis is carried out on the mass spectrum data through the intelligent fuzzy expert system, and simulation with lower cost is carried out to generate a large amount of training data; the system is conductive to analyzing large samples, is suitable for nonprofessional operations, achieves monitoring personal health information in real time, and meets personalized medical service requirements.

Description

technical field [0001] The present invention relates to an intelligent mass spectrometry system for detecting biomolecules, which combines traditional mass spectrometry with artificial intelligence, adopts mature traditional mass spectrometry in experimental techniques, and uses artificial intelligence technology developed rapidly in recent years for experimental data processing and analysis. It belongs to the technical field of instrument manufacturing. Background technique [0002] For decades, researchers have conducted in-depth research on mass spectrometry in terms of high resolution and high sensitivity. At present, the resolution and sensitivity of mass spectrometry have been greatly improved, basically reaching the physical limit. Mass spectrometry, that is, the use of electric and magnetic fields to move moving ions (charged atoms, molecules or molecular fragments, including molecular ions, isotopic ions, fragment ions, rearranged ions, multiply charged ions, metast...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/22G06F19/28
CPCG16B30/00G16B50/00
Inventor 马庆伟薛恒钢白春雨张荣陈莲莲安娜战晓薇
Owner BIOYONG TECH
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