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Preparation method of Fe3O4 nanoparticles with cluster structure

A technology of ferric tetroxide and nanoparticles, which is applied in the directions of preparations, pharmaceutical formulations, and emulsion delivery for in vivo experiments, can solve the problems of dual-modal MRI diagnosis without ferric tetroxide nanoparticles, and achieve MR. The effect of imaging signal enhancement

Active Publication Date: 2018-07-27
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Retrieving domestic and foreign literatures has not yet found information on the construction of cluster-type ultra-small ferric oxide nanoparticles and their use in vivo T 1 -T 2 Related reports on bimodal MRI diagnosis

Method used

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  • Preparation method of Fe3O4 nanoparticles with cluster structure
  • Preparation method of Fe3O4 nanoparticles with cluster structure
  • Preparation method of Fe3O4 nanoparticles with cluster structure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Dissolve 0.65g of anhydrous ferric chloride in 40mL of diethylene glycol (also known as diethylene glycol, DEG), add 0.47g of sodium citrate (Na 3 Cit), stirred at 80°C for 1 h in an air atmosphere, and then added 1.312 g of anhydrous sodium acetate powder after the sodium citrate was completely dissolved, and continued to stir until the sodium acetate powder was completely dissolved, then transferred the solution to a 50 mL autoclave, and React at 200°C for 4 hours; after the reaction, naturally cool to room temperature, transfer the product to a 50mL centrifuge tube and centrifuge at 8500rpm for 15 minutes, discard the supernatant, redissolve with absolute ethanol, centrifuge at 8500rpm for 15 minutes, repeat the operation 3 times, The precipitate was then dried at 60°C to obtain ultra-small Fe 3 o 4 Nanoparticles, ultra-small iron oxide nanoparticles with sodium citrate stabilized surfaces.

[0041] (2) Ultra-small Fe in step (1) 3 o 4Nanoparticles (30mg) wer...

Embodiment 2

[0044] Get ultra-small Fe in embodiment 1 respectively 3 o 4 Fe nanoparticles and clusters 3 o 4 / 2 mg of Cystamine nanoparticles were dissolved in 2 mL of ultrapure water to obtain a nanoparticle suspension, which was uniformly ultrasonicated, and the surface potential and hydrated particle size were measured. The test results are shown in Table 1. The test results show that: the prepared ultra-small Fe 3 o 4 Fe nanoparticles and clusters 3 o 4 The surface potentials of / Cystamine nanoparticles were -33.2 and -21.4mV respectively; the hydrated particle diameters were 25.6 and 134.4nm. From the experimental results, the surface potential of monodisperse ultra-small iron oxide nanoparticles increases after cross-linking into clusters, and the hydrodynamic diameter increases significantly. Changes in surface potential and hydrated particle size indicate cluster Fe 3 o 4 / Cystamine nanoparticles have been formed.

[0045] Table 1

[0046] sample

Embodiment 3

[0048] Get ultra-small Fe in embodiment 1 respectively 3 o 4 Fe nanoparticles and clusters 3 o 4 / Cystamine nanoparticles 5mg carry out infrared spectrum test (such as figure 1 shown) and thermogravimetric analysis (as figure 2 shown). By analyzing the infrared spectrum (such as figure 1 ), 466-601cm -1 The characteristic absorption peaks appearing on the Fe 3 o 4 Stretching vibration of upper Fe-O, 3451cm -1 The nearby peak is the stretching vibration peak of OH on the water molecule, 2931cm -1 and 2800cm -1 The nearby characteristic absorption peak is attributed to the stretching vibration of methylene in sodium citrate. At the same time at 1396-1642cm -1 It is the stretching vibration of C=O. And the strong absorption peak of 1736 in the curve b belongs to the amino group and Fe of cystamine dihydrochloride 3 o 4 An amide bond formed by binding carboxyl groups on the surface. 551cm -1 The characteristic peak at the position is obviously enhanced, which s...

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Abstract

The invention relates to a preparation method Fe3O4 nanoparticles with a cluster structure. The preparation method comprises steps as follows: preparation of extra small Fe3O4 nanoparticles, preparation of an activated extra small Fe3O4 nanoparticle solution, and preparation of the Fe3O4 nanoparticles with the cluster structure. The preparation method is simple, the prepared Fe3O4 / Cystamine nanoparticles have good stability and biocompatibility, are sensitive to reducing conditions, can realize T1-T2 dual-mode MR imaging effect of a tumor location in an animal body, can be effectively taken asan MR imaging contrast medium and have industrialized and commercialized application prospect.

Description

technical field [0001] The invention belongs to the field of preparation of magnetic resonance imaging (MRI) contrast agents, in particular to a method for preparing ferric iron tetroxide nanoparticles with a cluster structure. Background technique [0002] Malignant tumors have always been the number one killer of human life, with the characteristics of high mortality, difficult treatment and rapid deterioration. Therefore, early diagnosis and specific treatment of tumors are particularly important. Currently, tumor detection methods mainly include ultrasound imaging, CT imaging, nuclear medicine (PET or SPECT) imaging, and magnetic resonance imaging (MRI). With the development of magnetic resonance technology, the scanning time is gradually shortened, the resolution is gradually improved, and the detection of small lesions is more accurate, which also makes magnetic resonance imaging technology a new disease detection method developed in recent years. In order to improve...

Claims

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Application Information

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IPC IPC(8): A61K49/18
CPCA61K49/1887
Inventor 史向阳马丹彭琛张九龙史梦晗陆诗怡
Owner DONGHUA UNIV
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