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Preparation method of enzymolysis-type bioglass dental pulp repair material

A technology of biological glass and repair materials, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of poor pulp activity and inability to exist for a long time, achieve good biological activity, increase service life, and reduce enzymatic degradation Effect

Inactive Publication Date: 2018-07-13
周荣
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] The technical problem to be solved by the present invention: Aiming at the problem that the existing dental pulp restoration materials cannot exist for a long time due to the proteolytic enzymes in saliva, and the restoration activity of the dental pulp is poor, an enzymatic hydrolysis type bioglass pulp restoration material is provided. Preparation

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  • Preparation method of enzymolysis-type bioglass dental pulp repair material

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Embodiment Construction

[0016] Take soybeans and crush and grind them, pass through a 200-mesh sieve to obtain sieved soybean granules and add the soybean granules to deionized water at a mass ratio of 1:5, stir and mix them, and place them at 0-5°C for 10-12 hours. Filter and collect the filtrate, add dropwise to the filtrate with glacial acetic acid until the pH reaches 4.5, let it stand and age for 25-30 minutes, and then centrifuge at 4550-5000r / min for 10-15 minutes to obtain the lower layer precipitate and vacuum freeze-dry, grind Obtain modified powder; weigh 55-60 parts of deionized water, 3-5 parts of chitosan, and 3-5 parts of modified powder respectively in parts by weight, stir and mix and let stand for 6-8 hours to obtain a mixed solution Add glutaraldehyde dropwise to the mixed liquid at a volume ratio of 1:1, and control the acceleration rate of the mixed liquid droplet to 2-3mL / min. After the dropwise addition is completed, vacuum freeze and grind to obtain immobilized particles; In t...

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Abstract

The invention relates to a preparation method of an enzymolysis-type bioglass dental pulp repair material, and belongs to the technical field of a medical material. According to the technical scheme of the invention, the dental pulp repair material is prepared by using ethyl orthosilicate, triethyl phosphate and the like as raw materials, so that a body fluid micro environment is alkaline; the enzymolysis-type bioglass dental pulp repair material is beneficial for promoting expression of proteins related to dentinogenesis of dental pulp cells, meanwhile, has excellent bioactivity and ability of forming hydroxyapatite by mineralization and is hopeful to promote formation of reparative dentin; meanwhile, bioglass is dissolved out by ions; regulation of a micro environment of dental pulp tissues is hopeful to promote differentiation of the dental pulp cells to odontoblast, and promotes dentin matrix protein expression; by fixing a protein inhibiting enzyme inside the material, a service life of the dental pulp repair material is effectively prolonged.

Description

technical field [0001] The invention relates to a preparation method of an enzymolysis type biological glass pulp restoration material, which belongs to the technical field of medical materials. Background technique [0002] Teeth play an irreplaceable role in vocalization and chewing throughout the human life cycle. Dental pulp is the only soft tissue in the tooth. While providing oxygen and nutrients for odontoblasts and their cell processes, it also has the function of continuously forming dentin. Dental caries, tooth wear, and dental trauma are common oral diseases. Trauma and dental caries are the two main causes of exposed dental pulp. Preserving vital pulp is of great significance to the health of teeth. Pulp capping is the main method to preserve vital pulp. According to the location of pulp capping, it can be divided into two types: indirect pulp capping and direct pulp capping. Indirect pulp capping is to preserve the healthy dentin very close to the pulp, and to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/12A61L27/20A61L27/36A61L27/50A61L27/54
CPCA61L27/10A61L27/12A61L27/20A61L27/3637A61L27/50A61L27/54A61L2300/30A61L2300/434A61L2430/12C08L5/08
Inventor 周荣韩桂林
Owner 周荣
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