Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Iron(II) casein succinylate and preparation method and application thereof

A technology for succinyl casein and casein, which is applied in the field of medicine, can solve the problems of poor tolerance, gastrointestinal irritation, and reduced bioavailability, and achieves the effects of good product purity, high reaction yield and good properties.

Pending Publication Date: 2018-07-10
河北凯盛医药科技有限公司
View PDF7 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After these inorganic metal iron salts are ingested by the human body, some metal ions are not only difficult to be absorbed, but also stimulate the gastrointestinal tract, cause diarrhea, and have extremely poor tolerance
In addition, the antagonism between different metal elements will also limit the utilization and deposition efficiency of metal elements absorbed into the body, resulting in a decrease in their bioavailability
[0006] The second type is organic small molecule iron complexes formed by organic acids or amino acids and iron, such as ferrous oxalate, ferrous succinate; ferrous tartrate, ferrous fumarate, ferrous ascorbate, ferrous lactate, gluconic acid Ferrous iron, ferrous aspartate, etc. Compared with inorganic iron preparations, this type of iron preparation has fewer side effects and has been improved to a certain extent in terms of safety and tolerance, but it is still not ideal

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Iron(II) casein succinylate and preparation method and application thereof
  • Iron(II) casein succinylate and preparation method and application thereof
  • Iron(II) casein succinylate and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (a) Preparation of casein succinic acid

[0039] At 25°C, 5g of casein was suspended in 40ml of water, and stirred for 30min. Add 4 mol / l NaOH solution to adjust the pH to 8.5. Take 1g of succinic anhydride and add it into the solution three times (the time interval between each addition is 300s), keep the pH at 8.5, and stir for 20 minutes. Centrifuge and take the supernatant or filtrate. Add 3 mol / l HCl to adjust the pH to 3.8 to precipitate casein succinic acid, separate by centrifugal filtration, and wash the precipitate with water.

[0040] (b) Iron loading reaction

[0041] Then add about 105ml of water, add 4mol / l NaOH solution to adjust the pH value to 8.5 to obtain casein succinic acid solution, under nitrogen protection conditions, take 1.136gFeCl2 Configured as a 12% solution, slowly added to the casein succinic acid solution, stirred for 15 minutes, and the pH was controlled at 6.0~7.0.

[0042] (c) refined

[0043] Add 3 mol / l HCl to adjust the pH to 3...

Embodiment 2

[0047] (a) Preparation of casein succinic acid

[0048] At 25°C, 5g of casein was suspended in 45ml of water, and stirred for 30min. Add 4 mol / l NaOH solution to adjust the pH to 9.0. Take 5g of succinic anhydride and add it into the solution three times (the time interval between each addition is 300s), keep the pH at 9.0, and stir for 20 minutes. Centrifuge and take the supernatant or filtrate. Add 3 mol / l HCl to adjust the pH to 4.6 to precipitate casein succinic acid, separate by centrifugal filtration, and wash the precipitate with water.

[0049] (b) Iron loading reaction

[0050] Then add about 110ml of water, add 4mol / l NaOH solution to adjust the pH value to 9.0 to obtain casein succinic acid solution, under nitrogen protection conditions, take 1.79gFeCl 2 Configured as a 12% solution, slowly added to the casein succinic acid solution, stirred for 15 minutes, and the pH was controlled at 6.0~7.0.

[0051] (c) refined

[0052] Add 3mol / l HCl to adjust the pH to 4...

Embodiment 3

[0056] (a) Preparation of casein succinic acid

[0057] At 30°C, 5g of casein was suspended in 75ml of water, and stirred for 20min. Add 4mol / l NaHCO 3 The pH of the solution was adjusted to 8.0. Take 5g of succinic anhydride, add it into the solution three times (the time interval between each addition is 300s), keep the pH at 8.0, and stir for 20min. Centrifuge and take the supernatant or filtrate. Add 3 mol / l HCl to adjust the pH to 4.6 to precipitate casein succinic acid, separate by centrifugal filtration, and wash the precipitate with water.

[0058] (b) Iron loading reaction

[0059] Then add about 110ml of water, add 4mol / l NaOH solution to adjust the pH value to 8.0 to obtain casein succinic acid solution, under nitrogen protection conditions, take 1.63gFeCl 2 Configured as a 12% solution, slowly added to the casein succinic acid solution, stirred for 15 minutes, and the pH was controlled at 6.0~7.0.

[0060] (c) refined

[0061] Add 3mol / l HCl to adjust the pH...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine and relates to a preparation method of iron(II) casein succinylate. Casein is subjected as a material to acylation reaction with a succinylation reagent under certain conditions so as to obtain casein succinylate; the casein succinylate is complexed with a ferrite to obtain iron(II) casein succinylate. The iron(II) casein succinylate is in solid state, odorless and insoluble in water at normal temperature. The iron content in the iron(II) casein succinylate reaches 5% and above; casein succinylate and iron(II) complexing rate is not lessthan 98%; the iron(II) casein succinylate is suitable for the treatment of patients with iron-deficiency anemia and patients with iron deficiency symptoms.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a ferrous protein succinate and a preparation method and application thereof. [0002] The iron (II) casein succinylate (iron(II) casein succinylate) (succinyl casein-ferrous iron) involved in the present invention is characterized in that the iron content is more than 5%, wherein the complexation of succinyl casein and ferrous ion The rate is not less than 98%, which can be used to prevent and treat iron deficiency anemia and patients with iron deficiency symptoms. Background technique [0003] As we all know, iron is one of the essential trace elements for the human body. It is an important component of hemoglobin, myoglobin and various enzymes in human blood, and has important physiological effects on the human body. Anemia refers to the pathological phenomenon that the number of red blood cells or hemoglobin in the circulating blood is lower than the normal valu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07K14/47C07K1/107A61K38/17A61P7/06
CPCC07K14/4732A61K38/00
Inventor 赵凯王瑛
Owner 河北凯盛医药科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com