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A kind of preparation method of iron protein succinate

A technology of iron protein succinate and casein, which is applied in the field of preparation of iron protein succinate with a high degree of acylation, can solve the problems of high viscosity of iron protein succinate solution, poor solubility of iron protein succinate, difficult operation process, etc. To achieve the effects of slow dissolution rate, good water solubility and low viscosity of aqueous solution

Active Publication Date: 2022-01-18
WUHAN LEADPHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] During the preparation process of the above-mentioned iron protein succinate oral solution, there are generally problems such as poor solubility of iron protein succinate, slow dissolution rate, high viscosity of the prepared oral solution, and many sediments.
The high viscosity of ferric protein succinate solution can make it difficult to remove microorganisms by microfiltration during the preparation of oral solutions

Method used

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  • A kind of preparation method of iron protein succinate
  • A kind of preparation method of iron protein succinate
  • A kind of preparation method of iron protein succinate

Examples

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Embodiment 1

[0029] A preparation method for iron protein succinate, comprising the following steps:

[0030] Add 1.2Kg of purified water into a 5L reaction bottle, and add 100g of casein under stirring. After the addition, stir for 0.5 hour, add 2.5mol / L sodium hydroxide solution while stirring, adjust the pH value to be stable to 7.5 to dissolve the casein. Add a total of 300 g of succinic anhydride to the casein solution in 20 times, and add 2.5 mol / L sodium hydroxide solution while adding succinic anhydride to keep the pH value of the reaction solution at 7.5. After adding succinic anhydride, continue stirring for 30 minutes, add 3 mol / L hydrochloric acid to adjust the pH value of the reaction solution to 2.5, continue stirring for 30 minutes, filter to obtain succinylated protein wet solid. Add the succinyl protein wet solid into a 5L reaction flask, add 500g of purified water, add 2.5mol / L sodium hydroxide solution while stirring to adjust the pH value to 4.5, dissolve the succinyl ...

Embodiment 2

[0040] A preparation method for iron protein succinate, comprising the following steps:

[0041] In a 5L reaction bottle, add 1.2Kg of purified water, and add 100g of casein under stirring. After the addition, stir for 0.5 hour, add 2.5mol / L sodium hydroxide solution while stirring, adjust the pH value to be stable to 7.5 to dissolve the casein. A total of 300 g of succinic anhydride was added to the casein solution in 20 times, and the addition was completed in one hour. While adding succinic anhydride, 2.5 mol / L sodium hydroxide solution was added to keep the pH value of the reaction solution at 7.5. After adding succinic anhydride, continue to stir for 30 minutes, and then add 3 mol / L hydrochloric acid to adjust the pH value to 2.5. After continuing to stir for 30 min, filter to obtain a wet solid of succinyl protein. Add the succinyl protein wet solid into a 5L reaction flask, add 500g of purified water, and add 2.5mol / L sodium hydroxide solution while stirring to adjust...

Embodiment 3

[0045] A preparation method for iron protein succinate, comprising the following steps:

[0046] In a 5L reaction bottle, add 1.2Kg of purified water, and add 100g of casein under stirring. After the addition, stir for 0.5 hour, add 2.5mol / L sodium hydroxide solution while stirring, adjust the pH value to be stable to 7.5 to dissolve the casein. A total of 300 g of succinic anhydride was added to the casein solution in 20 times, and the addition was completed in one hour. While adding succinic anhydride, 2.5 mol / L sodium hydroxide solution was added to keep the pH value of the reaction solution at 7.5. After adding succinic anhydride, continue to stir for 30 minutes, and then add 3 mol / L hydrochloric acid to adjust the pH value to 2.5. After continuing to stir for 30 min, filter to obtain a wet solid of succinyl protein. Add the succinyl protein wet solid into a 5L reaction flask, add 500g of purified water, and add 2.5mol / L sodium hydroxide solution while stirring to adjust...

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Abstract

The invention relates to the technical field of pharmacy, and specifically discloses a preparation method of ferric protein succinate with a high degree of acylation. On the basis of the current preparation method of iron protein succinate, by preparing succinyl protein with high degree of acylation (degree of acylation > 99.3%), iron protein succinate with high degree of acylation is finally prepared, and its hydrophilic group is increased , increase its water solubility, reduce the viscosity of its aqueous solution, and solve the problems of high viscosity and many sediments in the iron protein succinate oral solution.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a method for preparing ferric protein succinate with a high degree of acylation. Background technique [0002] The iron in iron protein succinate combines with emulsion succinate protein to form an iron-protein complex, which is used to treat various iron-deficiency anemias. Its structure is as follows: [0003] [0004] Iron protein succinate is in the form of precipitates when the pH value is less than 4, and becomes soluble again when the pH value is high (pH7.5-8). In addition, ferric protein succinate is not digested by pepsin, but is hydrolyzed by trypsin at neutral pH. Due to these properties of iron protein succinate, the iron contained in it is protected by the protein film and does not react with hydrochloric acid and pepsin in gastric juice, so it will not cause gastric mucosal damage. The iron in ferric protein succinate begins to be released in the duodenum, b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/47C07K1/107
CPCC07K14/4732
Inventor 王革吴波谢树伟陈蔚江
Owner WUHAN LEADPHARM TECH CO LTD
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