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Detection kits used for detecting ALL related genes

A detection kit and the technology of the kit, applied in the field of molecular biology, can solve the problems such as the limitation of ALL diagnostic methods, and achieve the effects of high detection efficiency and high detection rate

Inactive Publication Date: 2018-07-06
天津见康华美医学诊断技术有限公司
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Problems solved by technology

[0004] The present invention aims at the technical defects of the prior art, and provides a detection kit for detecting ALL-related gene groups, so as to solve the problem that the diagnostic methods of ALL in the prior art are relatively limited and lack the basis for diagnosing ALL from the perspective of molecular biology. technical problem

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  • Detection kits used for detecting ALL related genes
  • Detection kits used for detecting ALL related genes
  • Detection kits used for detecting ALL related genes

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Embodiment Construction

[0027] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments. Unless defined otherwise, technical and scientific terms used in the following examples have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0028] Materials and methods:

[0029] Among the patients diagnosed from August 2015 to February 2017 at the Hematology Hospital of Chinese Academy of Medical Sciences and Union Medical Diagnostic Center, according to the following criteria, we performed continuous enrollment (273 patients).

[0030] Inclusion criteria were: patients diagnosed with acute lymphoblastic leukemia (ALL) by cytomorphology and flow cytometry.

[0031] The diagnostic results of 273 patients are shown in Table 2:

[0032] Table 2 List of patient diagnosis results

[00...

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Abstract

The invention discloses a group of sequencing kits which are used for screening ALL related gene mutation, and a subsequent medical science decoding database. The ALL related genes comprise 16 genes including FAT1 and KRAS. The sequencing kits comprise multiple PCR primers which are used for amplification of all the exons of the 16 ALL related genes. The detection kits used for screening ALL genemutation are high in detection efficiency, wide in mutation gene coverage, and high in detection rate; and obtained medical science decoding reports are accurate and authoritative.

Description

technical field [0001] The invention relates to the technical field of molecular biology, and further relates to a detection kit for screening ALL-related gene mutations and a medical interpretation database thereof, in particular to a detection kit for detecting ALL-related gene groups. Background technique [0002] ALL (acute lymphoblastic leukemia) is a malignant tumor originating from a single B or T lymphocyte precursor cell. Proliferation and accumulation of blast cells in the bone marrow lead to suppression of normal hematopoiesis, resulting in anemia, thrombocytopenia, and neutropenia. ALL can be divided into various subtypes according to immunology, cytogenetics and molecular genetics. The annual incidence of ALL is about 1.6 per 100,000 people, slightly more men than women, accounting for nearly 12% of all leukemias. The disease is most common in children, but can occur at any age. The exact pathogenesis of ALL is not yet clear, but it is generally believed that...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/106C12Q2600/118C12Q2600/156
Inventor 汝昆蔺亚妮贾玉娇
Owner 天津见康华美医学诊断技术有限公司
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