Three-dimensional microfluidic chip capable of driving deterministic lateral displacement on basis of centrifugal force and Euler force

A lateral displacement, microfluidic chip technology, applied in methods of supporting/immobilizing microorganisms, bioreactors/fermenters for specific purposes, methods of sterilization, etc., can solve the problems of complex control structure and small driving force, etc. Achieve precise control and high driving force

Active Publication Date: 2018-07-06
XI AN JIAOTONG UNIV
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Other methods such as dielectric electromechanical force also have d...

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  • Three-dimensional microfluidic chip capable of driving deterministic lateral displacement on basis of centrifugal force and Euler force
  • Three-dimensional microfluidic chip capable of driving deterministic lateral displacement on basis of centrifugal force and Euler force
  • Three-dimensional microfluidic chip capable of driving deterministic lateral displacement on basis of centrifugal force and Euler force

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[0026] The present invention will be described in detail below in conjunction with the accompanying drawings.

[0027] refer to Picture 1-1 , Figure 1-2 , diagram 2-1 with Figure 2-2 , a three-dimensional microfluidic chip with deterministic lateral displacement driven by centrifugal force and Euler force, including three sets of centrally symmetrical flow channels fixed on three centrally symmetrical sleeves 13, the three sets of flow channels are centrally symmetrical, which can make The chip achieves better dynamic balance during operation; each group of flow channels includes blood storage chamber 1 for whole blood input, the outlet of blood storage chamber 1 is connected to the inlet of leukocyte filter chamber 2 for leukocyte filtration of whole blood, and leukocyte filter chamber 2 A packaging cover 14 is connected to the top, the outlet of the white blood cell filter chamber 2 is connected to the inlet of the centrifugal chamber 3 that separates blood into red bl...

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Abstract

A three-dimensional microfluidic chip capable of driving deterministic lateral displacement on the basis of centrifugal force and Euler force comprises more than two groups of centrically-symmetric flowing channels, wherein each flowing channel comprises a whole blood input type blood storing chamber; an outlet of each blood storing chamber is connected to an inlet of a leukocyte filtering chamberfor filtering leukocyte of the whole blood; an outlet of the leukocyte filtering chamber is connected to an inlet of a centrifugal chamber for separating blood into red cell suspension and blood plasma; an outlet of the centrifugal chamber is connected to an inlet of a liquid storing chamber for temporarily storing the blood plasma or providing a reaction environment; an outlet of the liquid storing chamber is connected to an inlet of a small-inside-diameter flowing channel for supplying cell screening or chromatography environment through a spiral flowing channel. With the adoption of the three-dimensional microfluidic chip, the liquid in the radial direction (centrifugal force), tangential direction (Euler force) and normal direction (gravity) can be controlled by simply controlling thespeed, the acceleration and the direction of a motor of a centrifugal system in rotating; the noncontact operation is realized; high driving powder can be supplied; moreover, the control accuracy isensured.

Description

technical field [0001] The invention belongs to the technical field of microfluidic chips, and in particular relates to a three-dimensional microfluidic chip that drives deterministic lateral displacement based on centrifugal force and Euler force. Background technique [0002] The current drive and control methods of liquid flow in microfluidic chips mainly include: gravity, mechanical force, centrifugal force, dielectric force and other drive and control methods, among which the centrifugal force drive and control method can form a centrifugal force field in the chip area and realize non-contact drive. It has the characteristics of high driving force, good stability, strong adaptability to materials and chip structures, and will not cause damage or pollution to the surface of the contact object. It has the advantages of simple structure, control flexibility, adaptability to working environment and various materials have unique advantages. Therefore, using the centrifugal ...

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Application Information

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IPC IPC(8): C12M1/36C12M1/12
CPCC12M23/16C12M29/04C12M41/00
Inventor 秦咸明王万军陈花玲吕社民贾书海秦浩晨
Owner XI AN JIAOTONG UNIV
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