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Pharmaceutical composition for treating acute cerebral hemorrhage and application thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of difficult curative effect, unable to meet the requirements of acute cerebral hemorrhage treatment and the like

Inactive Publication Date: 2018-06-29
张海峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These preparations are all traditional Chinese medicine preparations, and it is difficult to quickly exert their curative effect. Even if they can be used as clinical drugs, they cannot meet the requirements for the treatment of acute cerebral hemorrhage.

Method used

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  • Pharmaceutical composition for treating acute cerebral hemorrhage and application thereof
  • Pharmaceutical composition for treating acute cerebral hemorrhage and application thereof
  • Pharmaceutical composition for treating acute cerebral hemorrhage and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0256] Example 1: Preparation of a pharmaceutical composition for the treatment of acute cerebral hemorrhage

[0257] 1. Accurately take 100 grams of vitamin B6, under the condition of full nitrogen filling, dissolve vitamin B6 in 5000 ml of water for injection, fully dissolve, fine filter, according to the requirements under the item of vitamin B6 injection in the second part of "Chinese Pharmacopoeia" 2015 edition After passing the inspection, vitamin B6 injection was obtained;

[0258] 2. Accurately take 100 grams of N(2)-L-alanyl-L-glutamine, and dissolve it in 2000 ml of water for injection under the condition of full nitrogen filling. After fully dissolving, fine filter, according to the "Chinese Pharmacopoeia" 》Alanyl-glutamine injection item requirements of the 2015 edition passed the inspection, and N(2)-L-alanyl-L-glutamine injection concentrated solution was obtained;

[0259] 3. Calculate according to the prescription of "Chinese Pharmacopoeia" 2015 edition compou...

Embodiment 2

[0261] Example 2: Preparation of a pharmaceutical composition for the treatment of acute cerebral hemorrhage

[0262] The preparation method is the same as in Example 1, wherein 100 grams of vitamin B6 is used to prepare 5000 milliliters of vitamin B6; 100 grams of N(2)-L-alanyl-L-glutamine is used to prepare N(2)-L-alanyl - L-glutamine solution 2000 ml;

[0263] Compound amino acid (18AA), prepare 10000 milliliters of compound amino acid (18AA) solution according to the requirements of "Chinese Pharmacopoeia" 2015 edition compound amino acid injection (18AA);

[0264] Under the condition of full nitrogen filling, the three kinds of solutions were respectively injected into the small bags of the three-chamber co-extruded infusion bag, wherein the contents of each solution were: 250 ml of concentrated solution of vitamin B6 injection, 250 ml of N(2)-L-alanyl - 100 ml of L-glutamine injection concentrated solution, 500 ml of compound amino acid (18AA) injection; put the three-c...

Embodiment 3

[0265] Example 3: Preparation of a pharmaceutical composition for the treatment of acute cerebral hemorrhage

[0266]The preparation method is the same as in Example 1, wherein 100 g of vitamin B6 is prepared in 2500 milliliters according to the requirements under the vitamin B6 injection in the second part of the "Chinese Pharmacopoeia" 2015 edition; the inspection is qualified, and the vitamin B6 injection is obtained;

[0267] 100 grams of N(2)-L-alanyl-L-glutamine, prepared 1000 milliliters according to the requirements of "Chinese Pharmacopoeia" 2015 edition alanyl-glutamine injection items, and the inspection is qualified to obtain N(2)- L-alanyl-L-glutamine injection concentrated solution;

[0268] Compound amino acid injection (15AA) is: L-isoleucine 90.0g, L-leucine 110.0g, L-lysine hydrochloride 86.0g, L-methionine 10.0g, L-phenylpropanoid Amino acid 10.0g, L-threonine 45.0g, L-tryptophan 6.6g, L-valine 84.0g, L-arginine 60.0g, L-histidine 24.0g, glycine 90.0g, L -...

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Abstract

The invention relates to a pharmaceutical composition for treating acute cerebral hemorrhage. The pharmaceutical composition comprises a vitamin B6 injection, a concentrated solution of N(2)-L-alanyl-glutamine injection concentration, a compound amino acid (15AA)-containing injection or a compound amino acid (18AA)-containing injection, which are placed in a three-chamber co-extrusion infusion bag. Pharmacodynamic experiments show that the pharmaceutical composition has an excellent effect of treating acute cerebral hemorrhage of rats and rabbits. The pharmaceutical composition has effects ofpreventing further bleeding, decreasing intracranial pressure, controlling cerebral oedema, maintaining vital functions, preventing and curing complications and the like; the pharmaceutical composition has excellent curative effects of treating endogenous acute cerebral hemorrhage and exogenous acute cerebral hemorrhage, and is an ideal medicine for treating the acute cerebral hemorrhage.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically relates to a pharmaceutical composition for treating acute cerebral hemorrhage and its application. Background technique [0002] Acute cerebral hemorrhage is mostly acute and critical, whether it is endogenous cerebral hemorrhage caused by hypertension or exogenous cerebral hemorrhage caused by trauma. [0003] Since the brain tissue is the nerve center, the blood clots produced by bleeding and the accompanying edema will oppress the brain tissue, and at the same time, the violation of blood secretions and the stress response of internal organs will make the disease develop and deteriorate rapidly. treatment, the consequences can be severe. [0004] At present, the treatment of acute cerebral hemorrhage mainly adopts symptomatic treatment, the principles are ① prevent further bleeding; ② reduce intracranial pressure; ③ control cerebral edema; ④ maintain life function and ...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K45/00A61K9/08A61P7/04A61P25/00A61K31/4415
CPCA61K38/05A61K9/0019A61K9/08A61K31/4415A61K45/00A61K2300/00
Inventor 吴军
Owner 张海峰
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