Konjac glucomannan surgical suture and preparation method thereof

Abstract

The invention relates to a konjac glucomannan surgical suture and a preparation method thereof. The preparation method of the konjac glucomannan surgical suture comprises steps of preparing a blend, preparing spinning dope and preparing the absorbable suture. Compared with absorbable surgical sutures prepared with general methods, the nanoscale konjac glucomannan surgical suture prepared from konjac glucomannan as the main material and other auxiliary materials capable of completely absorbed by a body through sufficient use of the advantages of high antibacterial property and viscoelasticity and good biocompatibility of konjac glucomannan has the advantages of being higher in antibacterial property and flexibility, low in friction coefficient, convenient to knot and the like, indexes suchas absorbing time, flexibility, raw material cost, safety and the like of the konjac glucomannan surgical suture are better than other surgical sutures in the market, and the konjac glucomannan surgical suture has huge potential market value.

Description

technical field [0001] The invention relates to a medical biological product and a preparation method thereof, in particular to a konjac glucomannan surgical suture and a preparation method thereof, belonging to the technical field of medical appliances. Background technique [0002] Surgical suture is one of the important materials in surgical operation and trauma treatment, and it is mainly used for various ligation and hemostasis, suture hemostasis, and tissue suture. Surgical sutures are mainly divided into two categories: non-absorbable sutures and absorbable sutures. Compared with non-absorbable sutures, the main advantages of absorbable sutures are: no antigenicity (only slight tissue reaction when absorbed) ; No pyrogenicity; complete wound healing; no need to remove stitches, which reduces the pain of patients and reduces the chance of inducing infection. Therefore, absorbable sutures are the development trend of surgical sutures. [0003] Absorbable sutures are d...

AI Technical Summary

Problems solved by technology

The suture has the advantages of high fusion with the human body, can be completely absorbed by the human body, stable and reliable absorption, no obvious individual differences, and no toxic and side effects, but the cost is high and the antibacterial property is poor. The surgical suture prepared by spinning technology , there are also problems such as a high friction coefficient and the thickness of the suture cannot be precisely controlled.

[0005] The invention patent with application number 201410791577.9 "A preparation method of absorbable suture" (application date: 2014.12.19) introduces a method of separating protein chorion, purifying collagen fibers, degreasing and degreasing, and inactivating viruses. Absorbable sutures prepared by chrome tanning, cross-linking dehydration, polishing, chitosan atomization and other steps have the characteristics of high tensile strength, firm knotting, good biocompatibility, and thread body can be absorbed by the body, but the use of sheep The extraction of collagen fibers from casings is not only a complicated process, but also has poor antibacterial properties, and the viruses and bacteria contained in the raw materials are also difficult to be completely inactivated, which has certain toxic and side effects

[0006] The invention patent with the application number 201610439721.1 "A Surgical Absorbable Suture" (application date: 2016.06.16) introduces a suture containing 50-60 parts of polyimide, 2-8 parts of orange peel pectin, alginic acid 11-14 parts of sodium, 3-5 parts of agar, 3-8 parts of fibroin, 5-10 parts of tea polyphenols, 5-10 parts of sodium carboxymethylcellulose, 15-20 parts of sweet potato starch, 5 parts of linoleic acid -9 parts, angelica powder 10-15 parts, burnet powder 11-14 parts, panthenol 5-8 parts surgical absorbable suture, has good blood compatibility and tissue compatibility, no inflammatory reaction, Tension maintenance time and material absorption time are stable, degraded and absorbed, and the degradation products are safe, non-toxic and non-irritating to the human body, but the suture has poor tensile strength and high cost

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