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High-oxygen-isolation plant hollow capsule and preparation method thereof

A plant hollow capsule and capsule wall technology, which is applied in capsule delivery, medical preparations of non-active ingredients, drug combinations, etc., can solve problems such as easy adhesion to the inner wall of the capsule, high inner surface roughness, and affect the therapeutic effect. Achieve the effects of reducing oxygen transmission rate, prolonging storage time, and low puncture damage rate

Inactive Publication Date: 2018-06-12
上海祺宇生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although compared with gelatin capsules, hypromellose capsules are less likely to be broken when pierced, but there are still cases of broken capsule fragments, so it is necessary to further improve the toughness of hypromellose capsules to reduce puncture damage Rate
In addition, in order to facilitate the demoulding of hollow capsules, the roughness of the inner surface is relatively high, and the contents of the capsules are easy to adhere to the inner wall of the capsule, which affects the therapeutic effect of capsules, especially dry powder inhalation preparations for the treatment of respiratory diseases.

Method used

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  • High-oxygen-isolation plant hollow capsule and preparation method thereof
  • High-oxygen-isolation plant hollow capsule and preparation method thereof
  • High-oxygen-isolation plant hollow capsule and preparation method thereof

Examples

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Embodiment 1～22

[0049] According to the raw materials of the capsule wall shown in Table 1 and the raw materials and formula of the inner surface coating, the 3# vegetable hollow capsule of the present invention is prepared according to the following steps.

[0050] Step 1: Evenly disperse the inner surface coating raw materials shown in Table 1 in ethanol according to the ratio shown to obtain the inner surface coating mixed solution, then immerse the 3# capsule mold in the mixed solution containing the inner surface coating, Take out and dry to remove ethanol and cool to room temperature to form a layer of inner surface coating on the capsule mold surface;

[0051] Step 2: Dissolve the capsule wall raw materials shown in Table 1 in water to make a uniform aqueous solution, then immerse the capsule mold obtained in step 1 with a layer of inner surface coating in the above aqueous solution and dip in glue, take it out and dry it for demoulding Combined to get 3# plant hollow capsules.

[005...

Embodiment 23

[0058] Vegetable hollow capsules with the same thickness were prepared using the same capsule wall raw materials and outer surface coating raw materials and proportions as in Example 20, but without the plasma treatment in step 3 in the example.

Embodiment 24

[0060] Hypromellose hollow capsules with the same thickness were prepared by using the raw materials and proportions of the hydroxypropylmethylcellulose and the outer surface coating in Example 4, but the plasma treatment was carried out in a nitrogen atmosphere.

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Abstract

The invention discloses a plant hollow capsule. The inner surface of the capsule wall of the capsule contains one or more inner surface coatings, and the inner surface coatings contain one or more ofplant oil, animal oil, silicone oil or mineral oil. The plant hollow capsule has an extremely high oxygen isolation rate, the speed of oxygen entering the capsule is lowered, and the preservation timeof the capsule is prolonged. In addition, the roughness of the inner surface of the plant hollow capsule is extremely low, the adherence rate of the capsule content on the inner surface of the capsule is lowered, the toughness of the capsule is good, the piercing damage rate is low, and the capsule can be used for containing inhalable dry powder preparations and treating the diseases of the respiratory system. Meanwhile, the prepared plant hollow capsule is further subjected to plasma treatment, the performance above of the capsule is further improved, and the application range is wider.

Description

technical field [0001] The invention relates to the field of plant hollow capsules, in particular to a high oxygen barrier plant hollow capsule and a preparation method thereof. Background technique [0002] With the development of the pharmaceutical industry, capsules are developing very rapidly because they can be used for almost any drug, have no peculiar smell, are easy to swallow, easy to digest and absorb, and have no side effects on the body. They are widely used in the fields of food, medicine and health care products. [0003] The capsule is composed of a hollow capsule shell and its contents, and the hollow capsule shell can be divided into a gelatin hollow capsule and a vegetable hollow capsule. The traditional hollow capsule shell is composed of gelatin. Gelatin is partially degraded from collagen in connective tissues such as animal skin, bone, sarcolemma, and muscle. The main component of gelatin is protein, which is easily contaminated by microorganisms and is...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/38A61K47/44A61K47/34A61K9/72A61P11/00
CPCA61K9/0075A61K9/4816A61K47/34A61K47/38A61K47/44
Inventor 马雪华张宇
Owner 上海祺宇生物科技有限公司
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