Use of valeric acid in the preparation of a medicament for preventing and/or treating side effects of tumor radiotherapy
A technology for tumor radiotherapy and side effects, applied in the field of medicine, can solve problems such as side effects, amifostine's short duration of efficacy, and restrictions on wide application
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Embodiment 1
[0052] Example 1: Survival rate and weight detection of mice after abdominal local irradiation with γ-rays.
[0053] 1. Experimental animals:
[0054] C57BL / 6J mice, 6-8 weeks old, weighing about 20 g, male, were randomly divided into two groups: a control group and a valeric acid administration group, 30 mice in each group.
[0055] 2. Model establishment:
[0056] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 15Gy, and the dose rate is 1Gy / min.
[0057] 3. Administration method:
[0058] Valeric acid administration group: start administration 24 hours after irradiation, administration method: intragastric administration of valeric acid liquid, once a day at 2:00 p.m. ; Valeric acid solution (aqueous solution) concentrati...
Embodiment 2
[0065] Example 2: Detection of intestinal goblet cells in mice after abdominal local irradiation with γ-rays.
[0066] 1. Experimental animals:
[0067] C57BL / 6J mice, 6-8 weeks old, weighing about 20 g, male, were randomly divided into three groups: blank group, simple irradiation group and valeric acid administration group, 30 in each group.
[0068] 2. Model establishment:
[0069] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 12Gy, and the dose rate is 1Gy / min.
[0070] 3. Administration method:
[0071] Valeric acid administration group: start administration 24 hours after irradiation, administration method: intragastric administration of valeric acid liquid, once a day at 2:00 p.m. ; Valeric acid solution (aqueous so...
Embodiment 3
[0079] Example 3: Detection of colon length in mice after localized abdominal irradiation with γ-rays.
[0080] 1. Experimental animals:
[0081] C57BL / 6J mice, 6-8 weeks old, weighing about 20 g, male, were randomly divided into three groups: blank group, simple irradiation group and valeric acid administration group, 30 in each group.
[0082] 2. Model establishment:
[0083] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 12Gy, and the dose rate is 1Gy / min.
[0084] 3. Administration method:
[0085] Valeric acid administration group: start administration 24 hours after irradiation, administration method: intragastric administration of valeric acid liquid, once a day at 2:00 p.m. ; Valeric acid solution (aqueous solution)...
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