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Use of valeric acid in the preparation of a medicament for preventing and/or treating side effects of tumor radiotherapy

A technology for tumor radiotherapy and side effects, applied in the field of medicine, can solve problems such as side effects, amifostine's short duration of efficacy, and restrictions on wide application

Active Publication Date: 2020-09-25
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In summary, due to the short duration of efficacy of amifostine after administration and the side effects of its own administration, its wide application in clinical practice is limited.

Method used

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  • Use of valeric acid in the preparation of a medicament for preventing and/or treating side effects of tumor radiotherapy
  • Use of valeric acid in the preparation of a medicament for preventing and/or treating side effects of tumor radiotherapy
  • Use of valeric acid in the preparation of a medicament for preventing and/or treating side effects of tumor radiotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1: Survival rate and weight detection of mice after abdominal local irradiation with γ-rays.

[0053] 1. Experimental animals:

[0054] C57BL / 6J mice, 6-8 weeks old, weighing about 20 g, male, were randomly divided into two groups: a control group and a valeric acid administration group, 30 mice in each group.

[0055] 2. Model establishment:

[0056] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 15Gy, and the dose rate is 1Gy / min.

[0057] 3. Administration method:

[0058] Valeric acid administration group: start administration 24 hours after irradiation, administration method: intragastric administration of valeric acid liquid, once a day at 2:00 p.m. ; Valeric acid solution (aqueous solution) concentrati...

Embodiment 2

[0065] Example 2: Detection of intestinal goblet cells in mice after abdominal local irradiation with γ-rays.

[0066] 1. Experimental animals:

[0067] C57BL / 6J mice, 6-8 weeks old, weighing about 20 g, male, were randomly divided into three groups: blank group, simple irradiation group and valeric acid administration group, 30 in each group.

[0068] 2. Model establishment:

[0069] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 12Gy, and the dose rate is 1Gy / min.

[0070] 3. Administration method:

[0071] Valeric acid administration group: start administration 24 hours after irradiation, administration method: intragastric administration of valeric acid liquid, once a day at 2:00 p.m. ; Valeric acid solution (aqueous so...

Embodiment 3

[0079] Example 3: Detection of colon length in mice after localized abdominal irradiation with γ-rays.

[0080] 1. Experimental animals:

[0081] C57BL / 6J mice, 6-8 weeks old, weighing about 20 g, male, were randomly divided into three groups: blank group, simple irradiation group and valeric acid administration group, 30 in each group.

[0082] 2. Model establishment:

[0083] After adopting 0.3% chloral hydrate to anesthetize experimental mouse (anesthetic dose is 1ml / g), use 40Exactor carried out local irradiation of γ-ray abdomen on the whole abdomen of mice ( 40Exactor comes with a partial irradiation mold, the entire abdomen is fully exposed), the absorbed dose is 12Gy, and the dose rate is 1Gy / min.

[0084] 3. Administration method:

[0085] Valeric acid administration group: start administration 24 hours after irradiation, administration method: intragastric administration of valeric acid liquid, once a day at 2:00 p.m. ; Valeric acid solution (aqueous solution)...

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Abstract

The invention belongs to the field of medical technology, and relates to application of valeric acid in the preparation of medicine for preventing and / or curing tumor radiotherapy side reactions. Researches find that valeric acid can obviously improve intestinal injury, caused by partial irradiation on abdomen of gamma ray, of a mouse, so that the survival rate of the laboratory mouse is obviouslyincreased, the weight is expected to be increased, the level of intestinal inflammation is obviously reduced; and no paradoxical reaction appears on the laboratory mouse, so that valeric acid can beeffectively used for preventing and / or curing tumor radiotherapy side reactions, and the toxic and / or side effects are relatively low.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to the use of valeric acid in preparing medicines for preventing and / or treating side effects of tumor radiotherapy, in particular to the use of valeric acid in preparing medicines for preventing and / or treating side effects of radiotherapy for pelvic and abdominal tumors use in . Background technique [0002] Epidemiological studies have shown that cancer has become one of the diseases with the highest morbidity and mortality in the world. The 2017 cancer report shows that about 10,000 people are diagnosed with cancer every day, and an average of 7 people are diagnosed every minute. There are about 14.09 million new cases in the world, and China accounts for 1 / 4 of the world's new cases. [0003] Belly and abdominal tumors include digestive system tumors (such as gastric cancer, liver cancer, pancreatic cancer, colon cancer, rectal cancer, etc.), urinary system tumors (such as kid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/19A61P1/12A61P1/08A61P1/00A61P3/00
CPCA61K31/19
Inventor 崔明樊赛军李源肖惠文张书琴
Owner INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
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