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Bidirectional double-drug eluting stent and preparation method thereof

An eluting stent and dual-drug technology, applied in the field of eluting stents, can solve problems such as lumen loss, stent thrombosis, and stent stenosis, and achieve the effects of accelerating re-endothelialization, rapid endothelialization, and delayed endothelialization

Inactive Publication Date: 2018-06-05
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If new atherosclerosis occurs after drug-eluting stent implantation, it may cause in-stent thrombosis due to atheroma plaque instability and intimal rupture at any period from the beginning to in-stent restenosis, especially in the late stage. Stent thrombosis and loss of lumen due to progressive plaque, leading to stent restenosis

Method used

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  • Bidirectional double-drug eluting stent and preparation method thereof
  • Bidirectional double-drug eluting stent and preparation method thereof
  • Bidirectional double-drug eluting stent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The selected base stent is a cobalt alloy stent, and a solution with the following components is configured: the carrier material is polylactic acid, the solvent of atorvastatin is a mixed solvent of acetone and ether (mass ratio 2:8), and the solvent of tacrolimus is chloroform Mixed solvent with ethanol (mass ratio 1:1).

[0024] Polylactic acid (Mn=50000) 0.1g

[0025] Atorvastatin 1mg

[0026] Tacrolimus 20mg

[0027] Acetone 20ml + ether 80ml

[0028] Chloroform 50ml+ and ethanol 50ml

[0029] Mix the above systems separately and stir at 10 rpm to form a solution.

[0030] Clean the cobalt alloy stent and place it on an ultrasonic atomization sprayer. First, spray the atorvastatin / polylactic acid solution on the inside of the stent. The ultrasonic power is 0.1W, the solution flow rate is 0.01ml / min, and the number of sprays is 10 times. Finish drying at room temperature for 0.1 hour, and then spray tacrolimus / polylactic acid solution on the outside of the sten...

Embodiment 2

[0032] The selected substrate stent is a cobalt alloy stent, and a solution with the following components is configured: the carrier material is polylactic acid, the solvent of atorvastatin is a mixed solvent of acetone and ether (mass ratio 2:8), and the solvent of emodin is chloroform.

[0033]

[0034] Mix the above systems separately and stir at 300rpm to form a solution.

[0035] Clean the cobalt alloy stent and place it on an ultrasonic atomization sprayer. First, spray the atorvastatin / polylactic acid solution on the inside of the stent. The ultrasonic power is 20W, the solution flow rate is 0.5ml / min, and the number of sprays is 20 times. The spraying is completed. Dry at room temperature for 4 hours, and then use an ultrasonic atomization sprayer to spray the emodin / polylactic acid solution on the outside of the bracket. The ultrasonic power is 20W, the solution flow rate is 0.1ml / min, and the number of sprays is 30 times. After spraying, put the bracket on the Vac...

Embodiment 3

[0037] The selected base stent is a magnesium alloy stent, and a solution with the following components is configured: the carrier material of fluvastatin is polylactic acid-glycolic acid copolymer, and the solvent of fluvastatin is a mixed solvent of tetrahydrofuran and ether (mass ratio 9:1); The carrier material of mycin is polyglycolic acid, and the solvent is acetone.

[0038]

[0039] Mix the above systems separately and stir at 600rpm to form a solution.

[0040] Clean the magnesium stent and place it on an ultrasonic atomization sprayer. First, spray the fluvastatin / polylactic acid-glycolic acid copolymer solution on the inside of the stent. The ultrasonic power is 10W, the solution flow rate is 0.1ml / min, and the number of sprays is 40 times. After spraying, dry at room temperature for 4 hours, and then use an ultrasonic atomization sprayer to spray the rapamycin / polyglycolic acid solution on the outside of the bracket. The ultrasonic power is 10W, the solution flo...

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Abstract

The invention relates to a bidirectional double-drug eluting stent and a preparation method thereof. The bidirectional double-drug eluting stent is used for carrying out percutaneous coronary intervention operations so as to supply expansion support to heart and blood vessels of a patient. An A drug layer containing a drug capable of inhibiting the proliferation of smooth muscles is applied to theouter side surface, namely the surface in contact with an inner surface of a blood vessel after mounting, of the stent; and a B drug layer containing a drug capable of accelerating the reendothelialization of the blood vessel and stabilizing or reversing plaques is applied to the side surface, namely the surface deviated from the inner surface of the blood vessel after mounting, of the stent. According to the bidirectional double-drug eluting stent, the cell proliferation of the smooth muscles can be inhibited, so that the in-stent restenosis and the rapid endothelialization are inhibited, the plaques can be stabilized and reversed, the new atherosclerosis is prevented, and the occurring risk of later-period thrombus is reduced.

Description

technical field [0001] The invention relates to a cardiovascular interventional treatment device, in particular to an eluting stent for providing expansion support for a patient's cardiovascular system during percutaneous arterial interventional stent surgery. Background technique [0002] Cardiovascular disease has become one of the major diseases threatening human health. One of the most common cardiovascular diseases—coronary heart disease, referred to as coronary heart disease for short, refers to the abnormal lipid metabolism, the lipids in the blood are deposited on the original smooth arterial intima, forming a white plaque similar to atheroma. Plaques, called atherosclerotic lesions. Percutaneous arterial interventional stenting has become an important treatment. The development stages of stents are bare metal stents and drug eluting stents. The biggest problem with bare stents is intimal hyperplasia that leads to restenosis. The application of drug-eluting stent...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/14A61L31/16
CPCA61L31/10A61L31/148A61L31/16A61L2300/416A61L2300/422A61L2300/608C08L67/04
Inventor 王进李娜李欣赵元聪冷永祥黄楠
Owner SOUTHWEST JIAOTONG UNIV
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