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Premixed magnesium phosphate-based dental filling material with stable suspension as well as preparation method and application thereof

A magnesium phosphate-based dental and filling material technology, used in dental preparations, dentistry, dental prostheses, etc., can solve the problems of long coagulation time, fast hydration reaction speed, and troublesome preparation, and achieves insignificant reaction temperature rise and coagulation time. Long, doctor-friendly effect

Active Publication Date: 2018-06-05
BEIJING C ROOT DENTAL MEDICAL DEVICES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main components of the MTA material are tricalcium silicate and dicalcium silicate, which are similar to Portland cement and can be used in root canal filling materials, but the preparation is cumbersome and wasteful
The Chinese patent "Premixed Biological Hydraulic Cement Paste Composition and Its Application" (Patent No. CN200880011743.1) discloses a premixed cement paste that can be used for medical or dental purposes. Pre-mixing tricalcium silicate, dicalcium silicate and organic solvent is convenient for doctors to use, but the coagulation time is too long, and some need 72 hours to coagulate. Too long coagulation time not only leads to prolonged waiting time for patients, but also makes surgery difficult. more complicated process
The disadvantage is that the calcium phosphate bone cement is not strong enough and easy to break
Years of research have shown that MPC has good biocompatibility and is an ideal material for bone defect repair. However, due to the two problems of too fast hydration reaction speed and extremely large hydration heat release, MPC has not been used for a long time. received enough attention and research
For example, under adiabatic conditions, the maximum hydration temperature of MPC reaches nearly 70°C, and these problems have not been well resolved.

Method used

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  • Premixed magnesium phosphate-based dental filling material with stable suspension as well as preparation method and application thereof
  • Premixed magnesium phosphate-based dental filling material with stable suspension as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 Preparation of suspension stable pre-mixed magnesium phosphate based dental filling material 1

[0030] (1) Weigh the raw materials according to the following weight percentages: (a) 21% of dead-burned magnesium oxide; (b) 23% of potassium dihydrogen phosphate; (c) 37% of zirconium oxide and (d) 19% of polyethylene glycol;

[0031] (2) Put the components of step (1) into a glass container one by one, use a stainless steel stirring rod for mechanical mixing, and fully adjust for 5 minutes;

[0032] (3) Afterwards, the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a suspension and stable pre-mixed magnesium phosphate-based dental filling material.

[0033] The material is kept fluid under a sealed condition, extruded samples are placed in a constant temperature and humidity cabinet at 37°C and 95% humidity (or filled to the teeth in contact with physiological body fluids), hydration and hardening, hydration and hardening...

Embodiment 2

[0034] Example 2 Preparation of suspension stable pre-mixed magnesium phosphate based dental filling material 2

[0035] (1) Weigh the raw materials according to the following weight percentages: (a) Light burnt magnesium oxide 9%; (b) Sodium dihydrogen phosphate 12%; (c) Bioglass 63S 10%; (d) Anhydrous calcium dihydrogen phosphate 15%; and (e) tantalum oxide 33% (f) polyethylene glycol 21%;

[0036] (2) Put the components of step (1) into a glass container one by one, use a stainless steel stirring rod for mechanical mixing, and fully adjust for 5 minutes;

[0037] (3) Afterwards, the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a suspension and stable pre-mixed magnesium phosphate-based dental filling material.

[0038] figure 1 This is a photograph of the sample obtained in Example 2. The material is kept fluid under sealed conditions, and the extruded sample is placed in a constant temperature and humidity cabinet with a humidit...

Embodiment 3

[0039] Example 3 Preparation of a suspension stable pre-mixed magnesium phosphate-based dental filling material 3

[0040] (1) Weigh the raw materials according to the following weight percentages: (a) 7% of dead-burned magnesium oxide; (b) 7% of ammonia dihydrogen phosphate; (c) 20% of calcium dihydrogen phosphate; (d) 35 bismuth trioxide % And (e) 31% glycerol.

[0041] (2) Put the components of step (1) into a glass container one by one, use a stainless steel stirring rod for mechanical mixing, and fully adjust for 5 minutes;

[0042] (3) Afterwards, the mixed paste is transferred to a medical syringe equipped with an injection hose needle to obtain a suspension and stable pre-mixed magnesium phosphate-based dental filling material.

[0043] The material is kept fluid under sealed conditions, and the extruded samples are placed in a constant temperature and humidity cabinet with a humidity of over 95% at 37°C (or when the teeth are filled with physiological body fluids), hydrated a...

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Abstract

The invention discloses a premixed magnesium phosphate-based dental filling material with stable suspension as well as a preparation method and application thereof. The dental filling material with excellent injectable property is prepared from magnesium oxide, at least one phosphate, as well as at least one non-aqueous phase solvent capable of being mixed and dissolved with the water and at leastone irradiation resistance material, wherein the magnesium oxide and the at least one phosphate are taken as main phases; the filling material further comprises at least one type of bioglass. The material maintains a liquid state under a sealing condition; after the material is padded into teeth and is in contact with physiological body fluid, the material is hydrated, solidified and hardened. The premixed magnesium phosphate-based dental filling material with stable suspension is prepared from a magnesium phosphate-based material due to the excellent biocompatibility and biological activityof the magnesium phosphate-based material; the premixed magnesium phosphate-based dental filling material serving as the filling material can be used in the fields of pulp capping, root canal therapy,dental restoration and the like.

Description

Technical field [0001] The invention relates to a dental filling material and a preparation method and application thereof, in particular to a suspension stable pre-mixed magnesium phosphate-based dental filling material and a preparation method and application thereof. The invention belongs to the technical field of medical materials. Background technique [0002] Dental filling materials have a wide range of applications in dental clinics. According to its function, it can be divided into dental bonding filling materials, dental restoration filling materials and protective dental filling materials. The development of dental filling materials has gone through a long process. Many materials such as clove oil zinc oxide, zinc phosphate, silver amalgam, glass cement composite resin, etc. have been used as dental filling materials. The ideal dental filling material must have good biocompatibility, antibacterial properties and clinical performance. In addition, biological activity...

Claims

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Application Information

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IPC IPC(8): A61K6/033A61K6/027A61K6/02A61K6/838
CPCA61K6/80A61K6/836A61K6/838
Inventor 吴秉民
Owner BEIJING C ROOT DENTAL MEDICAL DEVICES CO LTD
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