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Method for preparing pyruvic acid from lactic acid through oxidative dehydrogenation by catalysis

A technology for pyruvic acid and catalytic conversion, which is applied in the direction of catalyst activation/preparation, carboxylate preparation, chemical instruments and methods, etc., and can solve the problems of underutilization of catalysts containing precious metals, increased device operating costs, hydrothermal pressure and energy consumption Large and other problems, to achieve the effect of putting into industrial production, low production cost and reducing energy consumption

Inactive Publication Date: 2018-05-25
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problem of this method is: reaction temperature is higher, and hydrothermal pressure and energy consumption are bigger, and the required production equipment requirement is higher, and side reaction is more, and pyruvic acid yield is about 55% (J.Mol.Catal .A:Chem.,2013,377,123-128)
However, the main problem at present is that the conversion efficiency of lactic acid is low, which makes the catalyst containing noble metal not fully utilized, and increases the operating cost of the device.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1. impregnation method prepares Pt-Te / AC catalyst

[0031] At room temperature, 0.14 g of chloroplatinic acid (Pt content: 38%) was dissolved in 10 mL of aqueous solution, and 0.06 g of TeO 2 Dissolve in 5ml of 6mol / L concentrated hydrochloric acid, mix the two evenly, add 5g of activated carbon carrier (AC) under vigorous stirring, dry in an air atmosphere at 50°C, place it in a vacuum oven at 80°C for 12h, then place it in a hydrogen atmosphere Reduction at 400°C for 4 hours to obtain a Pt-Te / AC catalyst.

[0032] In a 100mL three-necked round-bottomed flask, add 1.1g lactic acid (85wt%), 49mL deionized water, 0.86gNaOH and 0.50g Pt-Te / AC catalyst in sequence, install a reflux condenser and a thermometer, and pass it under magnetic stirring Oxygen was bubbled, and the oxygen flow rate was 100 mL / min. The temperature of the water bath was raised to 90° C. for 2 hours. After the reaction, it was cooled to room temperature, and the catalyst was recovered by c...

Embodiment 2

[0034] Example 2. Immersion - NaBH 4 Preparation of Graphite-supported Pd-Sn Bimetallic Catalysts by Reduction Method

[0035] At room temperature, quickly dissolve 0.15g of tin nitrate in 5mL of aqueous solution, impregnate 5g of graphite (Graphite) carrier in equal volume, dry in air atmosphere at 50°C, place it in a vacuum oven at 80°C for 12h, then place it in a hydrogen atmosphere for 400 ℃ reduction for 4h, after that, under full stirring, highly disperse the catalyst precursor prepared above in water, then slowly add the aqueous solution in which 0.14g (Pt content: 38%) of chloroplatinic acid was dissolved, and stir at 30°C for 0.25h , then slowly add dissolved 0.5gNaBH 4 The aqueous solution was stirred for 6h, filtered and washed until neutral, and dried at 120°C for 12h to obtain a Pd-Sn / Graphite catalyst. The reaction conditions of the catalytic oxidative dehydrogenation of lactic acid are the same as in Example 1, and the conversion rate of lactic acid is 46.7%, ...

Embodiment 3

[0036] Example 3. Preparation of mesoporous carbon-supported Pt-Bi bimetallic catalyst by impregnation and roasting method

[0037] At room temperature, 0.14 g of chloroplatinic acid (Pt content: 38%) and 0.12 g of bismuth nitrate were dissolved in 10 mL of deionized water, impregnated on a 5 g of mesoporous carbon (OMC) carrier, dried in an air atmosphere at 50 ° C, and then The Pt-Bi / OMC catalyst was obtained by calcining at 500° C. for 4 h under an argon atmosphere. The conditions of the catalytic oxidative dehydrogenation of lactic acid are basically the same as in Example 1, the reaction time is 4 hours, the conversion rate of lactic acid is 97.7%, and the selectivity of pyruvic acid is 67.2%.

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Abstract

The invention provides a method for preparing pyruvic acid from lactic acid through oxidative dehydrogenation under the mild condition and a catalyst applied to the method. According to the method, oxygen or air is taken as an oxidizing agent, water is taken as a solvent, reaction temperature is 20-100 DEG C, and reaction time is 0.2-36 h; the catalyst is a supported metal catalyst, a carrier is acarbon material or metal oxide, a main active ingredient is Pt or Pd, and auxiliary components are one or more of Te, Sn, Pb and Bi. Air or oxygen is taken as the oxygen source, the raw material lactic acid can be obtained from biomass resources and is green and environmentally friendly, and the cost is low; a preparation process of the catalyst is simple, and catalytic activity and selectivity are high; reaction conditions are mild, a product and the catalyst are easy to separate, and the method is suitable for industrial production and has good application prospect.

Description

technical field [0001] The invention relates to a preparation method of chemicals, and relates to a method for producing pyruvic acid under mild conditions by using lactic acid as a raw material, molecular oxygen as an oxidant, and water as a solvent. Background technique [0002] Pyruvate, also known as 2-oxopropionic acid or acetoformic acid, has become a widely used intermediate in organic synthesis because it has two functional groups, carbonyl and carboxyl. Its application fields cover agriculture (fungicides, herbicides), food (preservatives, antioxidants), cosmetics (brighteners), etc., especially in the field of medicine, pyruvate can be used to synthesize high blood pressure drugs, weight loss drugs and anti-aging drugs. Cancer drugs, etc., therefore, its market demand is expanding day by day. At the same time, the output of pyruvic acid can not meet the requirements, which is mainly limited by its higher production cost. The current methods for producing pyruvate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/373C07C59/19B01J23/62B01J23/644B01J27/057
CPCC07C51/373B01J23/626B01J23/628B01J23/6447B01J27/0576B01J37/0201B01J37/03B01J37/031B01J37/08B01J37/16B01J37/18C07C59/19
Inventor 丁云杰张晨王涛
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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