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Pharmaceutical composition containing parecoxib sodium

A technology of parecoxib sodium and its composition, which is applied in the field of pharmaceutical composition of parecoxib sodium, can solve the problems of large adverse reactions and reduce adverse drug reactions, so as to improve medication compliance, reduce adverse reactions, and improve life quality. The effect of quality improvement

Active Publication Date: 2018-05-25
YANGTZE RIVER PHARM GRP GUANGZHOU HAIRUI PHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to overcome the technical deficiency of large adverse reactions in the analgesic treatment process in the prior art, the present invention provides a pharmaceutical composition for analgesia, which uses parecoxib sodium and ginkgolide as active ingredients, the When the pharmaceutical composition is used for analgesic treatment, the two active components have a significant synergistic effect on analgesia, and can significantly reduce the adverse reactions of the drug, especially showing a significant protective effect on the liver, so it is suitable for development into clinical medicine

Method used

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  • Pharmaceutical composition containing parecoxib sodium
  • Pharmaceutical composition containing parecoxib sodium
  • Pharmaceutical composition containing parecoxib sodium

Examples

Experimental program
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Effect test

Embodiment 1

[0023] The freeze-dried powder injection of embodiment 1 pharmaceutical composition of the present invention

[0024] Prescription composition:

[0025]

[0026] Preparation process: Weigh parecoxib sodium, ginkgolide and mannitol respectively according to the prescription amount. Add mannitol to an appropriate amount of water for injection, stir to dissolve and adsorb with 0.1% (w / v) activated carbon, pre-filter with a 0.45 μm filter or filter membrane, add parecoxib sodium and stir to dissolve, and adjust the pH value to 7.0- 8.5, 0.45 μm filter or filter membrane pre-filtering, constant volume, 0.45 μm and 0.22 μm filter or filter membrane sterilization filtration, filling, semi-tamponing, freeze-drying to obtain the freeze-dried powder injection of the composition of the present invention .

Embodiment 2

[0027] The freeze-dried powder injection of embodiment 2 pharmaceutical composition of the present invention

[0028] Prescription composition:

[0029]

[0030] The preparation method is the same as Example 1 of the present invention except that the prescription is different.

Embodiment 3

[0031] The freeze-dried powder injection of embodiment 3 pharmaceutical composition of the present invention

[0032] Prescription composition:

[0033]

[0034]

[0035] The preparation method is the same as Example 1 of the present invention except that the prescription is different.

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Abstract

The invention relates to a pharmaceutical composition containing parecoxib sodium, and belongs to the field of medicine. The side effects of parecoxib sodium are increased along with the increase of dosage and exposure duration in the analgesic treatment process, the rise of liver transaminase will occur if parecoxib sodium is taken for a long time, and consequently the clinical application rangeof the drug is affected. In order to overcome the technical defect of large adverse reactions in the analgesic treatment process in the prior art, the pharmaceutical composition for analgesia is provided; parecoxib sodium and ginkgolide serve as active pharmaceutical ingredients of the pharmaceutical composition, and when the pharmaceutical composition is used for analgesic treatment, the two active ingredients have a significant synergistic effects in analgesia, can significantly reduce adverse reactions caused by drugs and show a significant protective effect on liver especially, so that thepharmaceutical composition is suitable for being developed into clinical treatment drugs.

Description

technical field [0001] The invention relates to a pharmaceutical composition of parecoxib sodium, which belongs to the field of medicine. Background technique [0002] Parecoxib sodium, chemical name: N-[[4-(5-methyl-3-phenyl-4-isoxazolyl)phenyl]sulfonyl]propionamide sodium salt. Parecoxib sodium is an injectable selective COX-2 receptor inhibitor. It is an inactive prodrug of valdecoxib. It has fast analgesic onset and short half-life. activity, can also inhibit peripheral and central sensitization, resulting in good analgesic effect. [0003] Parecoxib was declared for marketing in the European Union by Pfizer in March 2002. The trade name is "Tanai", which is the prodrug of valdecoxib. In May 2008, Pfizer Parecoxib Sodium for Injection was launched in my country in the form of powder injection with two specifications, 20mg and 40mg respectively. [0004] From the perspective of the sample hospital market, there was only one importer company included in the statistics o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/42A61K31/365A61P29/00
CPCA61K31/365A61K31/42A61K2300/00
Inventor 施猛夏春森任亚东刘志强张国文袁海成
Owner YANGTZE RIVER PHARM GRP GUANGZHOU HAIRUI PHARM CO LTD
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