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Pharmaceutical composition for treating urticaria and preparation method thereof

A composition and technology of urticaria, applied in the field of pharmaceutical composition for treating urticaria and its preparation, can solve problems such as poor dissolution rate of tablets, poor therapeutic effect, poor stability, etc., achieve optimal dissolution rate, maintain drug effective, good therapeutic effect

Inactive Publication Date: 2018-05-04
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Ebastine is almost insoluble in water, and the tablets made have poor dissolution rate, low bioavailability, difficult absorption in vivo, and poor therapeutic effect. Chinese patent document "(application number: 201310051928.8)" discloses a Dispersible tablet, the dissolution rate of the prepared ebastine dispersible tablet is not very good, and the absorption effect of the dispersible tablet in the human body is not good at the same time, in addition, it is easy to be oxidized, and the stability is not good. X) " discloses a kind of pharmaceutical composition for the treatment of acetylcholine urticaria, and its pharmaceutical active ingredient is levocetirizine and promethazine, and the therapeutic effect is still not very good, still needs further improvement

Method used

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  • Pharmaceutical composition for treating urticaria and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0025] A kind of pharmaceutical composition for the treatment of urticaria of the present embodiment, comprises the raw material of following weight portion:

[0026] 44 parts of ebastine, 27 parts of compound glycyrrhizin, 3 parts of solubilizer, 1 part of cosolvent, 2 parts of suspending agent, 1 part of leaching auxiliary agent, 1 part of flavoring agent, 1 part of antioxidant, 11 parts of solvent share.

[0027] The solubilizer in this embodiment is polyoxyethylene sorbitan fatty acid ester.

[0028] The cosolvent of this embodiment is diethylamine.

[0029] The suspending agent of this embodiment is ethyl hydroxyethyl cellulose.

[0030] The leaching auxiliary agent in this embodiment is dilute phosphoric acid.

[0031] The flavoring agent in this embodiment is a mixture of sodium saccharin and sorbitol in a weight ratio of 2:1.

[0032] The antioxidant in this embodiment is p-hydroxytert-butylanisole.

[0033] The solvent in this embodiment is a mixture of water, et...

Embodiment 2

[0038] A kind of pharmaceutical composition for the treatment of urticaria of the present embodiment, comprises the raw material of following weight portion:

[0039] 48 parts of ebastine, 31 parts of compound glycyrrhizin, 5 parts of solubilizer, 2 parts of cosolvent, 4 parts of suspending agent, 3 parts of leaching auxiliary agent, 2 parts of flavoring agent, 2 parts of antioxidant, 12 parts of solvent share.

[0040] The solubilizer in this embodiment is polyoxyethylene sorbitan fatty acid ester.

[0041] The cosolvent of this embodiment is diethylamine.

[0042] The suspending agent of this embodiment is ethyl hydroxyethyl cellulose.

[0043] The leaching auxiliary agent in this embodiment is dilute phosphoric acid.

[0044] The flavoring agent in this embodiment is a mixture of sodium saccharin and sorbitol in a weight ratio of 2:1.

[0045] The antioxidant in this embodiment is p-hydroxytert-butylanisole; the solvent is a mixture of water, ethylene glycol, and aceton...

Embodiment 3

[0049] A kind of pharmaceutical composition for the treatment of urticaria of the present embodiment, comprises the raw material of following weight portion:

[0050] 45.5 parts of ebastine, 29.5 parts of compound glycyrrhizin, 4 parts of solubilizer, 1.5 parts of co-solvent, 3 parts of suspending agent, 2 parts of leaching auxiliary agent, 1.5 parts of flavoring agent, 1.5 parts of antioxidant, 11.5 parts of solvent share.

[0051] The solubilizer in this embodiment is polyoxyethylene sorbitan fatty acid ester.

[0052] The cosolvent of this embodiment is diethylamine.

[0053] The suspending agent of this embodiment is ethyl hydroxyethyl cellulose.

[0054] The leaching auxiliary agent in this embodiment is dilute phosphoric acid.

[0055] The flavoring agent in this embodiment is a mixture of sodium saccharin and sorbitol in a weight ratio of 2:1.

[0056] The antioxidant in this embodiment is p-hydroxytert-butylanisole; the solvent is a mixture of water, ethylene glycol,...

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Abstract

The invention relates to the field of pharmaceutical preparations and specifically discloses a pharmaceutical composition for treating urticaria and a preparation method thereof. The pharmaceutical composition disclosed by the invention is prepared from the following raw materials in parts by weight: 44 to 48 parts of ebastine, 27 to 31 parts of compound glycyrrhizin, 3 to 5 parts of solubilizer,1 to 2 parts of cosolvent, 2 to 4 parts of suspending agent, 1 to 3 parts of extracting aid, 1 to 2 parts of flavoring agent, 1 to 2 parts of antioxidant and 11 to 12 parts of solvent. According to the pharmaceutical composition for treating urticaria disclosed by the invention, the two matters of the ebastine and the compound glycyrrhizin which are difficult to dissolve are dissolved together through the solvent; by means of adding the cosolvent, solubility of medicine in the solvent is improved; the solubilizer and the cosolvent are mutually matched to perform scientific compatibility to achieve the maximum solubility and the best treatment effect.

Description

technical field [0001] The invention relates to the technical field of urticaria treatment, in particular to a pharmaceutical composition for treating urticaria and a preparation method thereof. Background technique [0002] Urticaria, commonly known as urticaria, is a localized edema reaction due to the expansion and increased permeability of small blood vessels in the skin and mucous membranes. Without leaving any traces, the etiology of urticaria is very complicated, and about 3 / 4 of the patients cannot find the cause, especially chronic urticaria. The common causes mainly include: food and food additives; inhalation, infection, drugs, physical factors such as Mechanical stimulation, cold and heat, sunlight, etc.; the basic damage is skin wheals, often preceded by skin itching, random wheals, bright red or pale, skin color, a few patients have edematous erythema, the size of the wheals and The shape is different, the onset time is uncertain, the wheal gradually spreads, ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K31/445A61K31/198A61K47/26A61K47/18A61K47/38A61K47/04A61P17/00
CPCA61K31/704A61K31/198A61K31/445A61K47/02A61K47/18A61K47/26A61K47/38A61K2300/00
Inventor 朱露晶
Owner 湖南博隽生物医药有限公司
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