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Iridium nano intelligent composite medicine and preparation method thereof

A kind of drug and nanotechnology, applied in the field of biomedicine, can solve the problems that there is no preparation of chitosan/γ-polyglutamic acid and iridium nanoparticle target-targeted drugs, and achieve small side effects, good stability, and promote sustainable development. The effect of controlled release

Active Publication Date: 2018-04-20
QUFU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report on the preparation of oligochitosan / γ-polyglutamic acid and iridium nanoparticles targeting drugs

Method used

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  • Iridium nano intelligent composite medicine and preparation method thereof
  • Iridium nano intelligent composite medicine and preparation method thereof
  • Iridium nano intelligent composite medicine and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0027] A preparation method for an iridium nano-intelligent composite drug, the steps comprising:

[0028] 1) Add 6 ml of chloroiridic acid solution (Ir element concentration about 0.5 mg / mL) into the reaction flask, react at 100°C for 10 min, and end the reaction. After the solution was cooled to 90°C, 20 mL of ethanol was added for precipitation. Centrifuge at 15000 r / min for 5 min in a centrifuge to obtain a pellet. Wash the pellet with acetone and deionized water and centrifuge 3 times. Finally, the separated nanopowder is redispersed in deionized water to obtain a reaction system of iridium nanoparticles (particle size 10-30nm, polydispersity coefficient below 0.2);

[0029] 2) Add 4 mg chitosan oligosaccharide to the reaction system in step 1), mix, react at 95 ° C for 1 hour, ultrasonicate for 10 minutes, centrifuge, and ball mill the large particles in liquid nitrogen for 120 minutes to a particle size of 30 nm, add 4 mg chitosan oligosaccharide and 50 mg γ-polyglut...

Embodiment 2

[0034] A preparation method for an iridium nano-intelligent composite drug, the steps comprising:

[0035] 1) Add 6 ml of chloroiridic acid solution (Ir element concentration about 0.5 mg / mL) into the reaction flask, react at 100°C for 10 min, and end the reaction. After the solution was cooled to 90°C, 20 mL of ethanol was added for precipitation. Centrifuge at 15000 r / min for 5 min in a centrifuge to obtain a pellet. Wash the pellet with acetone and deionized water and centrifuge 3 times. Finally, the separated nanopowder is redispersed in deionized water to obtain a reaction system of iridium nanoparticles (particle size 10-30nm, polydispersity coefficient below 0.2);

[0036] 2) Add 3 mg chitosan oligosaccharide to the reaction system in step 1), mix, react at 95°C for 1 hour, ultrasonicate for 10 minutes, centrifuge, and ball mill the large particles in liquid nitrogen for 150 minutes to a particle size of 20 nm, add 5 mg chitosan oligosaccharide and 50 mg of γ-polyglu...

Embodiment 3

[0041] A preparation method for an iridium nano-intelligent composite drug, the steps comprising:

[0042] 1) Add 8 ml of chloroiridic acid solution (Ir element concentration about 0.5 mg / mL) into the reaction flask, react at 100°C for 10 min, and end the reaction. After the solution was cooled to 90°C, 20 mL of ethanol was added for precipitation. Centrifuge at 15000 r / min for 5 min in a centrifuge to obtain a pellet. Wash the pellet with acetone and deionized water and centrifuge 3 times. Finally, the separated nanopowder is redispersed in deionized water to obtain a reaction system of iridium nanoparticles (particle size 10-30nm, polydispersity coefficient below 0.2);

[0043] 2) Add 5 mg chitosan oligosaccharide to the reaction system in step 1), mix, react at 95 ° C for 1 hour, ultrasonicate for 10 minutes, centrifuge, and ball mill the large particles in liquid nitrogen for 150 minutes to a particle size of 20 nm, add 3 mg chitosan oligosaccharide and 50 mg γ-polyglut...

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Abstract

The invention relates to an iridium nano intelligent composite carrier and a preparation method thereof, and belongs to the field of biomedicine. According to the method provided by the invention, chitosan oligosaccharide, gamma-polyglutamic acid and iridium nano-particles are compounded by adopting a high-temperature solution method, and particles below 100nm are generated after a crosslinking reaction of the three substances; the method is simple to operate; the obtained iridium nano targeted composite carrier presents a typical core-shell structure; the nano-crystals can have targeting andslow release capabilities by changing the pH value, and have a better future of clinical practical application compared with single iridium nano-particles.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to an iridium nano-intelligent compound medicine and a preparation method thereof. Background technique [0002] The way of drug delivery has a crucial impact on the therapeutic effect of cancer, and tumor-targeted drug delivery is very challenging. With the deepening of nanotechnology research in the field of biomedicine, magnetic nanomaterials have also received a lot of attention. The precious metal platinum has been used in more than 50% of cancer chemotherapy. The potential of other precious metals such as iridium can provide new targeted drugs to attack cancer cells in a new way, and can be used safely with minimal side effects. Combined with a variety of targets in cells, such as DNA, RNA and protein. However, the biocompatibility of iridium nanoparticles is not ideal, and the aggregation between particles leads to an increase in particle size and poor stability, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/24A61K47/36A61K47/34A61P35/00
CPCA61K33/24A61K47/34A61K47/36
Inventor 杨革李媛车程川巩志金梁鑫鑫
Owner QUFU NORMAL UNIV
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