Novel flavone-derived polymer nano-drug and application thereof to oncotherapy

Abstract

The invention relates to a novel flavone-derived polymer nano-drug. The novel flavone-derived polymer nano-drug is obtained in the way that hydrophobic flavone micromolecules are in covalent linkage with heparin polysaccharide macromolecules through joint arms to form an amphiphilic graft polymer, and the amphiphilic graft polymer is self-assembled in a waterborne medium to constitute a primary combination strategy of the nano-drug in oncotherapy. Hydrophobic oncotherapy drugs with different action mechanisms are loaded under such intermolecular forces as a pi-pi stacking function and a hydrophobic driving function and incorporated into a nano-system, so that the internal water solubility, the stability and the targeting property of the hydrophobic oncotherapy drugs are effectively improved to realize a secondary combination strategy of the nano-drug in oncotherapy. The nano-system loaded with the oncotherapy drugs with different mechanisms can ensure cooperation and flexible selectionaccording to clinical requirements to realize tertiary combination strategy of the nano-drug in oncotherapy. Therefore, an oncotherapy mode which attaches importance to various treatment means can berealized, and the anti-tumor effect is maximized and optimized.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to the construction of a novel flavone-derived polymer nano-medicine and its application in tumor treatment. Background technique [0002] The multidrug resistance, heterogeneity and complex relationship between tumors and the microenvironment are serious problems in the current tumor treatment. It may be difficult to achieve a good anti-tumor effect with a single treatment. At present, in clinical practice, the three main methods of tumor treatment are surgical resection, chemotherapy and radiotherapy. The above methods have played their respective advantages in tumor treatment, but at the same time, they inevitably have certain defects, such as difficult resection during surgical resection. Small lesions, easy recurrence, long radiation therapy cycle, easy damage to immune function and normal cells, and severe side effects of chemotherapy drugs. In recent years, the disco...

AI Technical Summary

Problems solved by technology

However, its limitations are: most photosensitizers are very hydrophobic, and are easily removed quickly in the body, and there are agglomeration and instability, which makes it difficult to administer systemically; Consider the toxicity of the solvent; photosensitizers are easily combined with plasma proteins after entering the body, and the high binding rate makes most of them remain in the blood circulation, while only a small part may enter the tumor tissue; some researchers try to make photosensitizer molecules affinity Water-based modification, such as modifying hydrophilic groups such as glucose and lactose outside the aromatic ring, although the water solubility has increased, it still cannot solve the defects of small-molecule photosensitizers in the diffuse distribution and low selectivity of the whole body, so that the use of certain When some photosensitizers are used, patients need to avoid direct sunlight and cannot go out during the day, which will bring serious physical and mental damage to patients.

Images