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Nanosheet hydroxyapatite/gel composite film with brick-mud structure and preparation method thereof

A technology of hydroxyapatite and nano flakes, which is applied in the field of preparation of nano biomedical materials, can solve the problems of difficult preparation of flake HAp, not easy to disperse, difficult to form composite materials, etc., to achieve good biological activity and biophase Capacitive, superior mechanical properties, low cost effects

Active Publication Date: 2018-04-13
EAST CHINA JIAOTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there are few reports on composite materials using flake HAp as the inorganic component.
The main reason is not only because the preparation of flake HAp is difficult, but also because HAp is highly polar and not easy to disperse, so it is difficult to form a composite material with a brick-mud structure.

Method used

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  • Nanosheet hydroxyapatite/gel composite film with brick-mud structure and preparation method thereof
  • Nanosheet hydroxyapatite/gel composite film with brick-mud structure and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1, preparation has the nanosheet hydroxyapatite / gelatin composite film of brick-mud structure, and the steps are as follows:

[0018] Step 1) 15ml of deionized water and 30ml of absolute ethanol were mixed, 0.1g of template agent SDS and 11.80g of Ca(NO 3 ) 2 4H 2 O and 3.96g of (NH 4 ) 2 HPO 4 Dissolve in the above mixed solvent, raise the temperature to 83°C for reflux reaction for 14h, pour the reactant into a beaker, seal it and settle at room temperature for 12 days to obtain nano-layered hydroxyapatite (L-HAp) with a double-layer ordered structure , its small-angle X-ray diffraction pattern is as figure 1 shown.

[0019] Step 2) Prepare a GelPBS solution with a concentration of 1% (pH=7.4), heat up to 80° C., add the prepared double-layer ordered structure L-HAp into the GelPBS solution, wherein the double-layer ordered structure L-HAp and The mass ratio of Gel is 25:75, and the nano-layered hydroxyapatite L-HAp / Gel with a double-layer structure ...

Embodiment 2

[0022] Embodiment 2, preparation has the nano-flaky hydroxyapatite / gelatin composite film of brick-mud structure, and the steps are as follows:

[0023] Step 1) is basically the same as that in Example 1, except that the addition amount of template agent SDS is changed from 0.1 g to 0.25 g to obtain L-HAp with double-layer ordered structure.

[0024] Step 2) is basically the same as that of Example 1, except that the concentration of the PBS solution of Gel is changed from 1% to 6%, the temperature of the heating is changed from 80°C to 60°C, and the prepared double-layer ordered structure L -HAp was added to the PBS solution of Gel to obtain L-HAp / Gel with a mass ratio of L-HAp to Gel of 35:65.

[0025] Step 3) is basically the same as in Example 1, except that the concentration of the PLL aqueous solution is changed from 0.1% to 0.5%, the amount of L-HAp / Gel added is changed from 0.5 mg to 1 mg, and finally the surface modified PLL is obtained and the interlayer L-HAp inter...

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Abstract

The invention discloses and provides a nanosheet hydroxyapatite / gel composite film with brick-mud structure, comprising L-Hap of double-layer structure; a Gel intercalation layer is arranged between layers of the L-Hap of double-layer structure, and the outer layer of the L-Hap of double-layer structure is modified with PLL (poly-L-lysine). Gel is intercalated between the layers of the L-Hap mainly by taking advantage of intercalation characteristics of the L-Hap of double-layer structure and double electrical properties of the Gel; the surface of the outer layer of the L-Hap is modified withpositively-charged PLL, and the nanosheet hydroxyapatite / gel composite film with brick-mud structure is formed in PBS (phosphate buffered solution) by means of layer-by-layer assembly. The nanosheet hydroxyapatite / gel composite film with brick-mud structure prepared herein is expected to gain excellent mechanical properties as well as good bioactivity and biocompatibility and is expected to servefor bone defect repair and regeneration.

Description

technical field [0001] The invention relates to the field of preparation of nano biomedical materials, in particular to a composite material composed of bionic structure nano sheet hydroxyapatite (HAp) and gelatin (Gel) and a preparation method. Background technique [0002] In bone repair and replacement materials and bone tissue engineering scaffold materials, hydroxyapatite plays an irreplaceable important role, because HAp is the main inorganic component of natural bone, it has good biodegradability, biophase Capacitance, biological activity and osteoconduction function, can form a firm osseointegration with bone tissue, and promote the growth of bone tissue. However, the performance defects of HAp (such as high brittleness) make it difficult to use alone in a load-bearing environment. Under this background, HAp composites were born. As early as the early 1980s, Bonfield et al. pioneered the use of HAp to enhance polyethylene artificial bone materials. Subsequently, co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/12A61L27/22A61L27/18A61L27/50
CPCA61L27/12A61L27/18A61L27/222A61L27/50A61L2400/12A61L2400/18A61L2430/02C08L89/00C08L77/04
Inventor 罗红林万怡灶杨志伟胡剑熊玲玲
Owner EAST CHINA JIAOTONG UNIVERSITY
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