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Preparation method of biodegradable hydrogel scaffold material for cardiac repair

A technology of biodegradable scaffold materials, applied in the field of preparation of hydrogel scaffold materials, can solve the problems of immune rejection, insufficient donor organs, etc., and achieve good biocompatibility, low curing shrinkage rate, and good degradation performance Effect

Active Publication Date: 2021-01-05
XIAN TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a method for preparing a biodegradable hydrogel scaffold for heart repair, so as to solve the problems of immune rejection caused by traditional allogeneic transplantation in the treatment of heart disease and serious shortage of donor organs, etc.

Method used

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  • Preparation method of biodegradable hydrogel scaffold material for cardiac repair
  • Preparation method of biodegradable hydrogel scaffold material for cardiac repair
  • Preparation method of biodegradable hydrogel scaffold material for cardiac repair

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The steps of a preparation method of a biodegradable hydrogel scaffold material for heart repair are as follows:

[0031] 1) Preparation of polyvalerolactone-polyethylene glycol-polyvalerolactone (PVL-PEG-PVL)

[0032] a. Weigh 2g of polyethylene glycol (PEG) (without water) and 4mL of δ-valerolactone (δ-VL) (without water) into the test tube and stir evenly, then add 0.138g of catalyst stannous octoate and stir well ;

[0033] b. Vacuumize the reaction system for 10 minutes to remove moisture and oxygen in the reaction system, and react the sealed system at a temperature of 120°C for 14 hours;

[0034] c. Dissolve the product obtained from the reaction in dichloromethane (DCM) and ultrasonically remove the bubbles in the solution, move the solution to a mold to remove the dichloromethane (DCM), and make the product into a film (PVL-PEG-PVL three-embedded Segment copolymer) for use.

[0035] 2) modified

[0036] a. In a dry round-bottomed flask under the protection ...

Embodiment 2

[0042] The steps of a preparation method of a biodegradable hydrogel scaffold material for heart repair are as follows:

[0043] 1) Preparation of polyvalerolactone-polyethylene glycol-polyvalerolactone (PVL-PEG-PVL)

[0044] a. Weigh 2g of PEG (PEG) (water removed) and 4mL of δ-valerolactone (δ-VL) (water removed) into a test tube and stir evenly, then add 0.021g catalyst stannous octoate and stir evenly;

[0045] b. Vacuumize the reaction system for 10 minutes to remove moisture and oxygen in the reaction system, and react the sealed system at a temperature of 130°C for 15 hours;

[0046] c. Dissolve the product obtained from the reaction in dichloromethane (DCM) and ultrasonically remove the bubbles in the solution, move the solution to a mold to remove the dichloromethane (DCM), and make the product into a film (PVL-PEG-PVL three-embedded Segment copolymer) for use.

[0047] 2) modified

[0048] a. In a dry round-bottomed flask under the protection of nitrogen, dissolve...

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Abstract

The invention relates to the technical field of biomedical materials and particularly relates to a preparation method of a biodegradable hydrogel scaffold material used for heart repair in order to solve problems that a conventional allograft method for treating heart diseases may cause immunological rejection and organ donors are in serious shortage. In the technical scheme, the preparation method includes steps of: 1) preparing PVL-PEG-PVL; 2) performing modification; and 3) preparing the hydrogel scaffold material.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for preparing a biodegradable hydrogel scaffold material for heart repair. Background technique [0002] Cardiac disease has high morbidity and mortality in clinical medicine, accounting for 12% of global mortality. Therefore, it seriously threatens the survival and health of human beings in the world today, and has a serious impact on people's lives. In the early years, the method of ventricular assist device and allogeneic heart transplantation were used to treat the damaged heart area, but the method of using ventricular assist device has problems such as large size, complicated structure and control, and high failure rate of the device. Although the method of allogeneic heart transplantation can effectively treat patients in the middle and advanced stages, it also has problems such as potential immune rejection and insufficient donor organs. The rise o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/18A61L27/52A61L27/58C08G63/91C08G63/664C08J3/075
CPCA61L27/18A61L27/52A61L27/58A61L2430/20C08G63/664C08G63/912C08J3/075C08J2367/04C08L67/04
Inventor 马爱洁罗涛
Owner XIAN TECH UNIV
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