Anari series mongolian drug intragastric floating sustained release preparation and preparation method thereof
A technology of floating and sustained-release preparations in the stomach, applied in the directions of pharmaceutical formulations, digestive system, pill delivery, etc., can solve the problems of reduced patient compliance, easy moisture absorption of powder, loss of drug efficacy, etc., to improve bioavailability, appearance, etc. Smooth and uniform, reducing adverse reactions
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Embodiment 1
[0040] Embodiment 1: the preparation of Anari-4 extract
[0041] Take 100g of pomegranate, 100g of cinnamon bark, 100g of white cardamom, and 100g of Piper piscifolia as the prescription medicinal materials and grind them, add 8-12 times the volume of 50%-90% ethanol, heat and reflux at 80°C-100°C for 3 times, each time for 60-90min , the extract was cooled to room temperature, suction filtered and combined, and the ethanol was recovered by rotary evaporation until there was no alcohol smell, concentrated to a clear paste with a density of 1.10, freeze-dried for 12-24 hours, and the dried extract was obtained, which was crushed through a 100-mesh sieve to obtain Ana Day-4 extract powder.
[0042] The preparation method of the following Anari series is exactly the same as that of the above Anari-4.
Embodiment 2
[0043] Embodiment 2: the preparation of Anari-5 extract
[0044] Take 250g of pomegranate, 15g of cinnamon, 150g of white cardamom, 100g of longan and 100g of dried ginger and grind them into pieces, add 8-12 times the volume of 50%-90% ethanol, heat and reflux at 80°C-100°C for 3 times, each time After 60-90 minutes, the extract was cooled to room temperature, suction filtered, combined, and the ethanol was recovered by rotary evaporation until it had no alcohol smell, concentrated to a clear paste with a density of 1.10, freeze-dried for 12-24 hours, and the dried extract was obtained, crushed through a 100-mesh sieve, Vested Anari-5 extract powder.
Embodiment 3
[0045] Embodiment 3: the preparation of Anari-6 extract
[0046] Take 100g of pomegranate, 100g of cinnamon, 100g of white cardamom, 100g of longan, 100g of dried ginger, and 100g of bright salt, which are prescribed medicines, and grind them, add 8-12 times the volume of 50%-90% ethanol, and heat and reflux at 80°C-100°C for extraction3 Each time, 60-90min each time, the extract was cooled to room temperature, suction filtered, combined, and the ethanol was recovered by rotary evaporation until there was no alcohol smell, concentrated to a clear paste with a density of 1.10, freeze-dried for 12-24h, and the dried extract was obtained, crushed 100-mesh sieve, acquired Anari-6 extract powder.
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