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Pouzolzia zeylanica var. microphylla gel ointment, preparation method and application thereof

A technology of multi-branch fog water kudzu and kudzu gel ointment, applied in the field of medicine, can solve the problems of skin discomfort, high adhesion, poor treatment effect and the like

Active Publication Date: 2018-03-27
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing gel ointments have low adhesion and cannot always adhere to the skin, resulting in poor therapeutic effect; and some have too much adhesion, which makes the skin uncomfortable when removed.

Method used

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  • Pouzolzia zeylanica var. microphylla gel ointment, preparation method and application thereof
  • Pouzolzia zeylanica var. microphylla gel ointment, preparation method and application thereof
  • Pouzolzia zeylanica var. microphylla gel ointment, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Example 1 The preparation of the extract of kudzu root

[0076] 1. Petroleum ether extraction

[0077] Soak pulverized kudzu powder (500g) in 8 times the amount (volume) of petroleum ether, heat and reflux for extraction twice, each time for 1h; remove the petroleum ether from the filter residue after filtration, and obtain petroleum ether extraction multi-twig kudzu, set aside;

[0078] In the embodiment of the present invention, except for 8 times the amount of petroleum ether used for soaking kudzu kudzu, other 6-10 times are applicable to the present invention; the number of petroleum ether extractions is at least 2 times, preferably 2-3 times. The embodiment selects 2 times; each extraction time except 1h, other times such as 0.5-2h / time are applicable to the present invention.

[0079] 2. Ethanol extraction

[0080] Add 8 times the amount of 70% (v / v) ethanol to the petroleum ether to extract Pueraria japonica, heat and reflux for extraction 3 times, each time ...

Embodiment 2

[0085] Example 2 Skeleton material type screening

[0086] Sodium polyacrylate, carbomer 980, polyvinyl alcohol, and carboxymethyl cellulose were mixed with distilled water to prepare three portions of 1% swelling solution; then 0.2% of cross-linking agent aluminum glycylate, hydroxide Aluminum hydrates were mixed evenly; then the viscosity was measured with an NDJ-8S rotational viscometer to judge their respective crosslinking speeds and crosslinking degrees. The measurement results are shown in Table 1.

[0087] Table 1 The average viscosity measurement results of different adhesives after adding different crosslinking agents

[0088] group

[0089] The measurement results show that sodium polyacrylate and carbomer 980 are more suitable viscosities. If the dosage is too small, the viscosity will not be enough, and if the dosage is too high, it will not be completely dissolved. Moreover, the viscosity of carbomer 980 alone is too high, making it difficult to form a...

Embodiment 3

[0090] Example 3 Skeleton material type screening

[0091] Carbomer 980, sodium polyacrylate, and the combination of carbomer 980 and sodium polyacrylate were cross-linked with the cross-linking agent glycerol, and then the viscosity was measured. The dosage and measurement results are shown in Table 2.

[0092] Table 2 Carbomer 980, sodium polyacrylate, carbomer and sodium polyacrylate and glycylic aluminum cross-linked average viscosity measurement results

[0093]

[0094] It can be seen from the measurement results in Table 2 that the cross-linked product of carbomer and sodium polyacrylate can be used as the matrix of gel ointment. Carbomer has good water absorption and is easy to disperse in water. The viscosity rises rapidly after bonding. Compared with single use of carbomer or sodium polyacrylate, the combination of sodium polyacrylate and carbomer has better viscosity and ductility, so sodium polyacrylate and carbomer are used together as the binder, and aluminum...

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Abstract

The invention discloses a pouzolzia zeylanica var. microphylla gel ointment, a preparation method and an application thereof. The pouzolzia zeylanica var. microphylla gel ointment is prepared by a medical pouzolzia zeylanica var. microphylla extract product used for treating supurative skin infection and medical auxiliary materials, which comprises a backing layer, a medical matrix layer and a cover layer, the medical matrix layer is composed of a medical pouzolzia zeylanica var. microphylla extract product and a matrix, and the matrix comprises a frame material, a cross-linking agent, a humectant, a filler, and distilled water. The gel ointment can avoid the disadvantages that for achieving treatment effect, according to a traditional administration mode of pouzolzia zeylanica var. microphylla, plasma concentration is increased, drugs dose is large, medication time is long, medical concentration at an affected part cannot be partially increased, and stimulation and allergy can be easily generated; the pouzolzia zeylanica var. microphylla gel ointment has the advantages of large drug loading, long drug effect, little irritation on skin, usage is convenient, and drug usage compliance for patients, and provides a novel administration dosage form for clinical application of pouzolzia zeylanica var. microphylla.

Description

Technical field: [0001] The invention relates to a gel ointment of traditional Chinese medicine extract and its preparation method and application, in particular to a traditional Chinese medicine gel ointment for treating purulent skin infection, its preparation method and application, and belongs to the technical field of medicine. Background technique [0002] As a new type of transdermal drug delivery preparation, gel ointment has some unique advantages due to its composition and structural characteristics: it is based on water-soluble polymer materials and has less allergic and irritating reactions to the skin; it has strong moisturizing properties and is compatible with the skin. Compatibility, affinity, and air permeability are good, and it feels comfortable to stick on the skin; the drug loading capacity is large, which is suitable for the characteristics of large dosage of traditional Chinese medicine; no organic solvent is used in the production process, which meets ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K36/185A61P17/02A61P31/04
CPCA61K9/7053A61K9/7061A61K36/185A61K2236/333A61K2236/39
Inventor 郭丽冰陈求芳陶曙红陈艳芬
Owner GUANGDONG PHARMA UNIV
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