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Blueberry microcapsules and preparation method thereof as well as composition capable of improving asthenopia

A technology for visual fatigue and blueberries, which is applied in microcapsules, drug combinations, capsule delivery, etc., can solve the problems of anthocyanin oxidation in blueberries and the reduction of active ingredients in blueberries, and achieve the effect of improving visual fatigue

Active Publication Date: 2018-03-20
永安康健药业(武汉)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, when blueberries are used as eye protection products, blueberries are mostly granulated directly in hot and humid conditions, but this will cause the anthocyanins in blueberries to be oxidized, and the content of active ingredients in blueberries will decrease

Method used

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  • Blueberry microcapsules and preparation method thereof as well as composition capable of improving asthenopia
  • Blueberry microcapsules and preparation method thereof as well as composition capable of improving asthenopia
  • Blueberry microcapsules and preparation method thereof as well as composition capable of improving asthenopia

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preparation example Construction

[0026] The invention provides a kind of preparation method of blueberry microcapsule, comprises the following steps:

[0027] (1) provide blueberry solution;

[0028] (2) mixing the blueberry solution obtained in the step (1) with sodium alginate to obtain a mixed solution;

[0029] (3) mixing the mixed solution obtained in the step (2) with the chitosan sol to obtain a cross-linked product;

[0030] (4) Mix the cross-linked product obtained in the step (3) with a curing agent to obtain blueberry microcapsules.

[0031] In the present invention, the preparation method of described blueberry solution preferably comprises the following steps:

[0032] (1) carry out diafiltration treatment with blueberry powder adopting alcohol solution, obtain blueberry leachate;

[0033] (II) performing microporous filtration on the leachate obtained in the step (I) to obtain a blueberry solution.

[0034] In the present invention, the blueberry powder is preferably diafiltered with an alco...

Embodiment 1

[0067] (1) Preparation of blueberry microcapsule powder: crush blueberries into coarse powder and pass through a 10-mesh sieve, weigh 1 kg of sieved blueberry coarse powder, fill it in a percolation cylinder, and infiltrate it with 50% edible ethanol with 8 times the volume. Filter, collect the leachate and adopt microporous filtration to obtain the filtrate, and concentrate the filtrate under reduced pressure to 1000ml for subsequent use. Add 20 g of sodium alginate to the filtrate and stir to dissolve it for later use. In addition, 30 g of chitosan was weighed and dissolved in 1000 ml of pure water containing 1% citric acid to swell completely and uniformly to form a 3% chitosan sol. Mix sodium alginate-blueberry solution and chitosan sol evenly, and add 30wt% CaCl prepared at a temperature of 50°C 2 The solution is used as a solidifying agent and stirred evenly, and rapidly cooled to about 10° C., filtered, washed with water, frozen and dried to obtain blueberry microcapsu...

Embodiment 2

[0072](1) Preparation of blueberry microcapsule powder: pulverize blueberries into coarse powder and pass through a 10-mesh sieve, weigh 1 kg of qualified blueberry coarse powder, fill it in a percolation cylinder, use 8 times the volume of 50% edible ethanol to percolate, collect The filtrate was filtered through micropores to obtain a filtrate, and the filtrate was concentrated under reduced pressure to 1000 ml for later use. Add 50 g of sodium alginate to the filtrate and stir to dissolve it for later use. In addition, 40 g of chitosan was weighed and dissolved in 1000 ml of pure water containing 1% citric acid to swell completely and evenly to form a 4% chitosan sol. Mix the sodium alginate-blueberry solution and the chitosan sol evenly, add the prepared 30% CaCl2 solution as a curing agent at a temperature of 50°C, stir evenly, and rapidly cool down to about 10°C, filter, wash with water, and freeze , dried blueberry microcapsule powder.

[0073] (2) Preparation of lute...

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Abstract

The invention provides a preparation method of blueberry microcapsules. The problems that blueberries are directly exposed in humid and hot air and are easily oxidized are effectively solved by carrying out covering treatment on the blueberries through a micro-encapsulation technology, and the bioactivity of the blueberries is kept. The invention further provides a composition capable of improvingasthenopia; the composition comprises a water-soluble mixture laminated layer and a fat-soluble mixture laminated layer; a water-soluble mixture comprises the blueberry microcapsules, taurine, beta-carotene, a disintegrating agent and pharmaceutically acceptable auxiliary materials. The composition capable of improving the asthenopia, provided by the invention, can be used for effectively improving symptoms including ophthalmalgia, eye swelling, photophobia, blurred vision and xerophthalmia.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a blueberry microcapsule, a preparation method thereof and a composition for improving visual fatigue. Background technique [0002] Blueberry, also known as lingonberry and blueberry, is a plant of the genus Vaccinium in the Rhododendronaceae family. It is known as the "Queen of Fruits" and "The Fruit of Color Contact". Blueberries have high health value, especially high medicinal value in relieving visual fatigue, are popular at home and abroad, and have been listed by the International Food and Agriculture Organization as one of the five health foods for human beings, with high economic value and broad development prospects. [0003] In addition to the sugar, acid, protein, fat, amino acid, VC and mineral elements contained in common fruits, blueberries are also rich in anthocyanins. Anthocyanins can promote the regeneration of rhodopsin in retinal cells and preven...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/45A61K9/50A61K47/36A61P27/02A61K31/185A61K31/015A61K31/23A61K31/122A61K35/60
CPCA61K9/2054A61K9/209A61K9/5036A61K31/015A61K31/122A61K31/185A61K31/23A61K35/60A61K36/45A61K2300/00
Inventor 丁红莉叶伟童辉
Owner 永安康健药业(武汉)有限公司
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