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Method for preparing honeysuckle essential oil-beta-cyclodextrin inclusion compound

A technology of cyclodextrin inclusion complex and honeysuckle essential oil, which is applied in the preparation of tobacco, medical preparations containing active ingredients, food science and other directions, can solve the problems of limited application, easy volatilization, poor stability, etc. The effect of improving stability and facilitating wide application

Inactive Publication Date: 2018-03-16
刘晓霞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Honeysuckle essential oil is extremely volatile and has poor stability, which seriously limits its application

Method used

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Examples

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Effect test

Embodiment 1

[0017] The preparation method of a honeysuckle essential oil-β-cyclodextrin inclusion compound of the present invention comprises the following preparation steps:

[0018] (1) Take 500g of fresh flower buds of honeysuckle, put them in a 10L round bottom flask, add 5L of deionized water, and use steam distillation to collect the distillate, about 1L;

[0019] (2) Add 35g / L NaCl to the distillate, dissolve it, let it stand for 1h, extract it with an equal volume of distilled water and ether, dry the extract with anhydrous sodium sulfate, distill it under reduced pressure to obtain the light yellow honeysuckle essential oil, place it in 5 ℃ refrigerator for use;

[0020] (3) Weigh a certain amount of honeysuckle essential oil, dissolve it in a small amount of absolute ethanol, slowly drop it into 100 mL of β-cyclodextrin saturated solution at the same temperature at a certain temperature, and stir at 300r / min for a certain period of time After that, take it out and cool it down ...

Embodiment 2

[0026] The preparation method of a honeysuckle essential oil-β-cyclodextrin inclusion compound of the present invention comprises the following preparation steps:

[0027] (1) Take 500g of fresh flower buds of honeysuckle, put them in a 10L round bottom flask, add 5L of deionized water, and use steam distillation to collect the distillate, about 1L;

[0028] (2) Add 35g / L NaCl to the distillate, dissolve it, let it stand for 1h, extract it with an equal volume of distilled water and ether, dry the extract with anhydrous sodium sulfate, distill it under reduced pressure to obtain the light yellow honeysuckle essential oil, place it in 5 ℃ refrigerator for use;

[0029] (3) Weigh a certain amount of honeysuckle essential oil, dissolve it in a small amount of absolute ethanol, slowly drop it into 100 mL of β-cyclodextrin saturated solution at the same temperature at a certain temperature, and stir at 300r / min for a certain period of time After that, take it out and cool it down ...

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PUM

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Abstract

The invention relates to a method for preparing a honeysuckle essential oil-beta-cyclodextrin inclusion compound. The method includes the steps of taking 500 g of fresh honeysuckle buds, placing the fresh honeysuckle buds in a 10 L round-bottom flask, adding 5 L of deionized water, and using a vapor distillation method to collect distillate which is about 1 L. The honeysuckle essential oil-beta-cyclodextrin inclusion compound prepared according to the method has light honeysuckle essential oil fragrance, and the inclusion rate of the honeysuckle essential oil can reach 68.95%. Through a preparation process, the volatilization rate of the honeysuckle essential oil is remarkably reduced, the honeysuckle essential oil stability is improved, the liquid honeysuckle essential oil is solidified,and thus the honeysuckle essential oil is applied widely conveniently.

Description

technical field [0001] The invention relates to a preparation method of honeysuckle essential oil-beta-cyclodextrin inclusion compound. Background technique [0002] Honeysuckle is the flower bud of Lonicera Lonicera, which contains various natural active ingredients such as chlorogenic acid, luteolin and honeysuckle essential oil. It is the main formula ingredient of various preparations such as Yinhuang Granules, Yinhuang Oral Liquid and Chaihuang Oral Liquid. Honeysuckle essential oil is a light yellow oily liquid prepared from honeysuckle flower buds by lipophilic organic solvent extraction, steam distillation, supercritical fluid extraction or molecular distillation. It is widely used in cigarettes, fragrances and daily cosmetics. Honeysuckle essential oil is extremely volatile and has poor stability, which seriously limits its application. β-cyclodextrin is a cylindrical molecule composed of 7 glucose groups connected by 1,4-glycosidic bonds. It has a ring-shaped ho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/61A61K8/92A61K8/73A24B3/12A23L33/115A23L33/125
CPCA61K8/922A23L33/115A23L33/125A23V2002/00A24B3/12A61K8/738A61K2236/331A23V2250/21A23V2250/5112
Inventor 刘晓霞
Owner 刘晓霞
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