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Manganese-zinc-ferrite targeting nano-composite carrier and preparation method thereof

A manganese-zinc ferrite and nanocomposite technology, which is applied in the field of biomedicine, can solve the problems of preparing chitosan oligosaccharide/γ-polyglutamic acid and manganese-zinc ferrite target targeting nanocarriers, etc. Magnetic properties, good dispersibility, simple operation effect

Active Publication Date: 2018-03-16
QUFU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There is no report on the preparation of oligochitosan / γ-polyglutamic acid and manganese zinc ferrite targeting nanocarriers

Method used

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  • Manganese-zinc-ferrite targeting nano-composite carrier and preparation method thereof
  • Manganese-zinc-ferrite targeting nano-composite carrier and preparation method thereof
  • Manganese-zinc-ferrite targeting nano-composite carrier and preparation method thereof

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Embodiment 1

[0032] A method for preparing a manganese zinc ferrite targeted nanocomposite carrier, the steps comprising:

[0033] 1) Weigh FeCl respectively according to molar ratio 53.8:13.0:33.2 3 ·6H 2 O, ZnSO 4 ·7H 2 O, MnSO 4 ·H 2 Put O in a beaker and dissolve it with 10mL deionized water; transfer it to a three-neck flask, heat and stir at 95°C, and add 10mgNaOH during this process, and react at constant temperature for 1h to obtain manganese-zinc ferrite (particle size: 10-30nm, polydispersity coefficient below 0.2) reaction system;

[0034] 2) Add 5 mg camptothecin to the reaction system in step 1) and stir for 30 minutes, then add 4 mg chitosan oligosaccharide, mix, react at 95 °C for 1 hour, ultrasonicate for 10 minutes, centrifuge, and ball mill the large particles in liquid nitrogen for 120 minutes to a particle size of 30nm, add 4mg chitosan oligosaccharide and 50mg γ-polyglutamic acid, react at 60°C for 1 hour, and freeze-dry for 12 hours to obtain manganese zinc ferr...

Embodiment 2

[0039] A method for preparing a manganese zinc ferrite targeted nanocomposite carrier, the steps comprising:

[0040] 1) Weigh FeCl separately according to the molar ratio 23:23:253 ·6H 2 O, ZnSO 4 ·7H 2 O, MnSO 4 ·H 2 Put O in a beaker and dissolve it with 10mL deionized water; transfer it to a three-neck flask, heat and stir at 95°C, and add 10mgNaOH during this process, and react at constant temperature for 1h to obtain manganese-zinc ferrite (particle size: 10-30nm, polydispersity coefficient below 0.2) reaction system;

[0041] 2) Add 5 mg of camptothecin to the reaction system in step 1) and stir for 30 minutes, then add 3 mg of chitosan oligosaccharide, mix, react at 95°C for 1 hour, ultrasonicate for 10 minutes, centrifuge, and ball mill the large particles in liquid nitrogen for 150 minutes to a particle size of 20nm, add 5mg chitosan oligosaccharide and 50mg γ-polyglutamic acid, react at 60°C for 1 hour, and freeze-dry for 12 hours to obtain manganese zinc ferri...

Embodiment 3

[0046] A method for preparing a manganese zinc ferrite targeted nanocomposite carrier, the steps comprising:

[0047] 1) According to the molar ratio of 12:4:1, weigh FeCl respectively 3 ·6H 2 O, ZnSO 4 ·7H 2 O, MnSO 4 ·H 2 Put O in a beaker and dissolve it with 10mL deionized water; transfer it to a three-neck flask, heat and stir at 95°C, and add 10mgNaOH during this process, and react at constant temperature for 1h to obtain manganese-zinc ferrite (particle size: 10-30nm, polydispersity coefficient below 0.2) reaction system;

[0048] 2) Add 5 mg camptothecin to the reaction system in step 1) and stir for 30 minutes, then add 5 mg chitosan oligosaccharide, mix, react at 95°C for 1 hour, ultrasonicate for 10 minutes, centrifuge, and ball mill the large particles in liquid nitrogen for 150 minutes to a particle size of 20nm, add 3mg chitosan oligosaccharide and 50mg γ-polyglutamic acid, react at 60°C for 1 hour, and freeze-dry for 12 hours to obtain manganese zinc ferri...

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Abstract

The invention relates to a manganese-zinc-ferrite targeting nano-composite carrier and a preparation method thereof. The preparation method is characterized in that a chemical co-precipitation methodis used to composite chitosan and gamma-polyglutamic acid with manganese-zinc ferrite, and particles below 100 nanometers are generated after the crosslinking reaction of the three substances above. The preparation method has the advantages that the method is simple to operate, the prepared manganese-zinc-ferrite targeting nano-composite carrier has a typical core-shell structure, the manganese-zinc-ferrite targeting nano-composite carrier which is magnetic nanocrystals can have targeting and sustained-release ability by changing the magnetic field and temperature, and the manganese-zinc-ferrite targeting nano-composite carrier is more promising in actual clinical application prospect as compared with the single manganese-zinc ferrite.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a manganese zinc ferrite / chitooligosaccharide / γ-polyglutamic acid targeting nanocarrier and a preparation method thereof. Background technique [0002] The way of drug delivery has a crucial impact on the therapeutic effect of cancer, and tumor-targeted drug delivery is very challenging. With the deepening of nanotechnology research in the field of biomedicine, magnetic nanomaterials have also received a lot of attention. As an important soft magnetic material, manganese zinc ferrite is widely used in transformers, magnetic cores, magnetic heads, etc. due to its application value and long-term basic research. In recent years, nano-manganese-zinc-ferrite has attracted widespread attention in the aspects of tumor hyperthermia and magnetorheological fluid due to its soft magnetic properties and high stability. However, due to the high specific surface area and strong magnetic dipole inter...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K9/51A61K47/02A61K47/36A61K47/34A61K31/4745A61P35/00
CPCA61K9/0009A61K9/5115A61K9/5146A61K9/5161A61K31/4745A61K41/0052
Inventor 杨革李媛车程川巩志金梁鑫鑫
Owner QUFU NORMAL UNIV
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