Multi-trace-element V pharmaceutical composition and uses thereof

Abstract

The present invention provides a new multi-trace-element pharmaceutical composition for preventing or treating the deficiency of various trace elements such as zinc, manganese, copper, chromium and selenium in humans and mammals, and syndromes thereof so as to reduce adverse reactions during treatment, such that the new multi-trace-element pharmaceutical composition has good safety, good compliance, new adaptive population and the like in the clinical process.

Description

technical field [0001] The present invention relates to the technical field of medicine, and specifically provides a pharmaceutical composition for injection of multiple trace elements for preventing or treating zinc, manganese, chromium, copper, selenium deficiency and syndromes thereof, as well as its preparation and application. Background technique [0002] Zinc is an indispensable trace element in organisms, participates in the synthesis of many enzymes in the body, and has important physiological regulation functions. In tissue respiration, zinc plays an important role in protein synthesis, erythrocyte membrane and hematopoiesis. Zinc can combine with mercaptans, block mercaptans and iron, inhibit the catalytic oxidation reaction of iron and form free radicals, zinc can also inhibit fat peroxidation, stabilize cell membranes and make them more resistant to free radical attacks Therefore, zinc is of great significance not only to cell growth but also to cell protection...

AI Technical Summary

Problems solved by technology

4. Lead to the reduction of insulin synthesis and secretion, affecting glucose metabolism

Although the physiological pH of the human body generally reaches about 7.4, the pH value in the preparation in the prior art is maintained at a very low level with sulfuric acid, and the general pH value is between 2.0 and 3.0 to prevent quality problems in the injection. Drug preparation and clinical intravenous infusion bring a certain degree of safety hazards and some adverse reactions, including vascular irritation or phlebitis, local necrosis, poor patient tolerance or clinical accidents, etc., especially once the injection is prepared Particles appear during the process or during the infusion, which is prone to accidental fatal dangers during the infusion of patients. These particles may be invisible to the naked eye in the absence of background, but these have been ignored for a long time

[0010] Multiple trace element injections of the prior art ( -5CONCENTRATE) is also not suitable for patients with acidosis and renal insufficiency in some cases, and clinical medication may bring adverse consequences when it is unknown or difficult to know in advance; [References: Literature 1, Yin Peida, The Pathogenesis of Distal Renal Tubular Acidosis, Foreign Medicine (Internal Medicine Volume), 1982, Issue 12; Document 2, Zhou Lei, et al. Analysis and Nursing of 12 Misdiagnosed Patients with Renal Tubular Acidosis, Chinese Practical Nursing Magazine, Issue 17, 2005;]

Images