Application of a kind of n-acetylated chitosan to inhibit tumor cell proliferation

Abstract

The invention discloses an application of N-acetylated chitohexaose for inhibiting the proliferation of tumor cells. The sugar residue at the reducing end of the N-acetylated chitohexaose is N-acetylglucosamine and the sugar residue at the 2th site from the reducing end has a glucosamine structure. A natural non-toxic chitosan oligosaccharide is used as a lead compound and through selective N-acetylation and ion exchange chromatography separation, a specific structural component of N-acetylated chitohexaose having strong anti-tumor activity is screened. The N-acetylated chitohexaose has a great significance to develop efficient and low-toxic marine anti-tumor innovative drugs.

Description

technical field [0001] The invention relates to the field of marine chemical engineering, in particular to an application of N-acetylated chitosan to inhibit tumor cell proliferation. Background technique [0002] For a long time, there has been no fundamental breakthrough in the effective treatment of tumors in clinical medicine. The conventional treatment methods are surgery, radiotherapy, and chemotherapy. Although they can play a certain role, they often cause malignant problems such as metastasis and recurrence, and eventually lead to The exhaustion of life. At present, although most anti-tumor drugs have a certain inhibitory and killing effect on tumor cells, they often also affect the metabolism of normal cells, causing rapid weight loss, and the thymus and spleen are significantly reduced, showing that anti-tumor drugs inhibit the immune function of the body. Therefore, finding natural antitumor drugs without toxic and side effects is an urgent problem to be solved ...

AI Technical Summary

Problems solved by technology

[0002] For a long time, there has been no fundamental breakthrough in the effective treatment of tumors in clinical medicine. The conventional treatment methods are surgery, radiotherapy, and chemotherapy. Although they can play a certain role, they often cause malignant problems such as metastasis and recurrence, and eventually lead to exhaustion of life

At present, although most antineoplastic drugs have a certain inhibitory and killing effect on tumor cells, they often also affect the metabolism of normal cells, causing rapid weight loss, and the thymus and spleen are significantly reduced, showing that antineoplastic drugs inhibit the immune function of the body.

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