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Transdermal preparation for treating oral mucositis caused by radiotherapy of tumor

A technology for oral mucositis and transdermal drug delivery, which is applied in the field of medicine and can solve problems such as poor efficacy, lack of ideal drugs for oral mucositis, and strong side effects

Active Publication Date: 2018-03-06
宋在明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, so far, there is still a lack of ideal drugs for the treatment of radiotherapy-induced oral mucositis.
Currently marketed drugs used as therapeutic drugs have problems such as poor efficacy or strong side effects

Method used

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  • Transdermal preparation for treating oral mucositis caused by radiotherapy of tumor
  • Transdermal preparation for treating oral mucositis caused by radiotherapy of tumor
  • Transdermal preparation for treating oral mucositis caused by radiotherapy of tumor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Preparation of Gel Transdermal Drug Delivery Preparation

[0039]

[0040] Preparation:

[0041] (1) Take Carbomer 940 and add water to swell, add glycerin to grind and moisten, then add triethanolamine dropwise and grind to form a gel matrix;

[0042] (2) Take hydroxypropyl methylcellulose, ethyl cellulose and 95% ethanol to mix and moisten, add water to dissolve, add uridine triethyl

[0043] acid ester to make liquid dispersion system A;

[0044] (3) Take amifostine, dissolve it in water, and make liquid dispersion system B;

[0045] (4) Add liquid dispersion system A and liquid dispersion system B into the gel matrix, grind while adding, add water to a total weight of 15000 g, and stir evenly to obtain a gel transdermal drug delivery preparation.

Embodiment 2

[0046] Example 2 Preparation of Gel Transdermal Drug Delivery Preparation

[0047]

[0048] Preparation:

[0049] (1) Take Carbomer 940 and add water to swell, add glycerin to grind and moisten, then add triethanolamine dropwise and grind to form a gel matrix;

[0050] (2) Take hydroxypropyl methylcellulose, ethyl cellulose and 95% ethanol to mix and moisten, add water to dissolve, add uridine triethyl

[0051] acid ester to make liquid dispersion system A;

[0052] (3) Take amifostine, dissolve it in water, and make liquid dispersion system B;

[0053] (4) Add liquid dispersion system A and liquid dispersion system B into the gel matrix, grind while adding, add water to a total weight of 10,000 g, and stir evenly to obtain a gel transdermal drug delivery preparation.

Embodiment 3

[0054] Example 3 Preparation of Gel Transdermal Drug Delivery Preparation

[0055]

[0056] Preparation:

[0057] (1) Take Carbomer 940 and add water to swell, add glycerin to grind and moisten, then add triethanolamine dropwise and grind to form a gel matrix;

[0058] (2) Take hydroxypropyl methylcellulose, ethyl cellulose and 95% ethanol to mix and moisten, add water to dissolve, add uridine triethyl

[0059] acid ester to make liquid dispersion system A;

[0060] (3) Take amifostine, dissolve it in water, and make liquid dispersion system B;

[0061] (4) Add liquid dispersion system A and liquid dispersion system B into the gel matrix, grind while adding, add water to a total weight of 15000 g, and stir evenly to obtain a gel transdermal drug delivery preparation.

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Abstract

The invention belongs to the field of medicine and particularly relates to a transdermal preparation for treating oral mucositis caused by radiotherapy of tumor. The transdermal preparation comprisesactive ingredients of 109-237 parts by weight of amifostine and 42-85 parts by weight of uridine triacetate. The transdermal preparation is administered externally at a daily dose level of milligrams,has a markedly improved effect on the oral mucositis caused by the radiotherapy, and can avoid the drop of blood pressure caused by large doses of amifostine hydrochloride to affect the health of patients with normal blood pressure or hypotension.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a transdermal drug delivery preparation for treating oral mucositis caused by tumor radiotherapy. Background technique [0002] Nasopharyngeal carcinoma is a malignant tumor that occurs in the mucosal epithelium of the nasopharynx. The most common location is the top of the nasopharyngeal roof and posterior wall, followed by the side wall, and the anterior and bottom walls are extremely rare. The incidence rate of this disease is low in other countries in the world, but the incidence rate in my country is significantly higher than other countries. Its epidemiological reasons are currently unknown. According to epidemiological statistics, patients with NPC in my country account for more than 80% of the total number of NPC patients in the world. Among them, there are also significant regional differences in the regional distribution of nasopharyngeal carcinoma patients in my c...

Claims

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Application Information

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IPC IPC(8): A61K31/661A61K31/7072A61K47/38A61K47/10A61K47/18A61K9/06A61P1/02
CPCA61K9/006A61K9/06A61K31/661A61K31/7072A61K47/10A61K47/18A61K47/38A61K2300/00
Inventor 宋在明赵锦华魏西福高继友
Owner 宋在明
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