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Novel acetylisovaleryltylosin tartrate premixing agent as well as preparation technology and application thereof

A technology of tyvanectin and preparation process, which is applied in the field of antibiotic products, can solve the problems that the comprehensive quality index of drugs is difficult to meet the satisfactory standard, the defects cannot be effectively improved, and the dust generation is large and side effects, etc., and the dust reduction effect is ideal, and the dust reduction effect is ideal. Significant effect, the effect of improving the cure rate

Inactive Publication Date: 2018-03-06
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At this stage, various enterprises and scientific research institutes have carried out many researches on tivalamectin products, but the research progress is slow, and the defects of tivalamectin-related products cannot be effectively improved. curative effect, but its production is inconvenient, the amount of dust generated in the production process is large, the side effects are obvious during the medication process, and the comprehensive quality index of the drug is still difficult to reach a satisfactory standard. Therefore, it is urgent to develop a new tyvanectin product, not only It has the advantages of convenient production, obvious dust reduction effect, and small side effects, and it must also meet the requirements that the curative effect of the product can be significantly enhanced

Method used

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  • Novel acetylisovaleryltylosin tartrate premixing agent as well as preparation technology and application thereof
  • Novel acetylisovaleryltylosin tartrate premixing agent as well as preparation technology and application thereof
  • Novel acetylisovaleryltylosin tartrate premixing agent as well as preparation technology and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Applicable formulation screening of new tyvalancin premix:

[0066] From above-mentioned 4 test examples as can be known, what the present invention will solve is the micropowder molding of tylamectin in the tylamectin premix, the reduction of dust in the production process (harm to production personnel), the formation of tylamectin granules and the Increase efficiency and reduce side effects. The solution to these problems depends on the selection of suitable auxiliary materials and auxiliary material combinations under appropriate processes.

[0067] (1) Preparation of new tyvanectin premix products with different formulas

[0068] Materials: The raw material formula is shown in Table 5, wherein the tyvalansin is tyvalosin tartrate.

[0069] Preparation process: prepare the new tyvanectin premix according to the following method:

[0070] 1) Take the wheat bran and rice husk, stir-fry with a slow fire until browned according to the traditional Chinese medicine cook...

Embodiment 2

[0089] Investigation of the curative effect of the new tyvalancin premix on swine panting disease:

[0090] Product: Taking the existing commercially available "Tyvalamectin Tartrate Premix" as a comparison, this premix is ​​produced and sold by Chengdu Qiankun Animal Pharmaceutical Co., Ltd.; according to the product quality evaluation results of Example 1, select Example Sample 59 prepared in 1 was used as a new type of tyvalancin premix product for testing, and was named "Xinchaotai" (sample 59 in Example 1).

[0091] Case: 75 pigs with panting disease naturally occurred in a pig farm in Meishan (short and continuous coughing of pigs is most likely to be heard when they are stimulated by cold air after leaving the pen in the morning, or before and after driving and feeding, and coughing at the same time A small amount of clearing nasal fluid, and the flow of grayish white viscous or purulent nasal fluid in severe cases).

[0092] Method: Under the same feeding conditions, ...

Embodiment 3

[0099] Investigation on the control effect of new tyvanectin premix on porcine Clostridioides welchii

[0100] Product: with existing commercially available " tyvalactin tartrate premix " as contrast, this premix is ​​produced and sold by Chengdu Qiankun Animal Pharmaceutical Co., Ltd.; according to the product quality evaluation result of embodiment 1, select embodiment The sample 59 prepared in 1 was used as the tyvalansin premix product for testing, and was named "Xinchaotai" (sample 59 in Example 1).

[0101] Case: 90 pigs suspected to have Clostridium welchii disease in a pig farm in Pixian County (a pig in the herd died suddenly, with obvious abdominal distension after death, cyanosis of ear tips, hoofs, nasolabial parts; Clostridium welchii test was positive ).

[0102] Method: Under the same feeding conditions, the tested pigs were randomly divided into positive control group, test group and negative control group; among them: 1) the positive control group was treated...

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Abstract

The invention relates to the related technical field of antibiotic products and in particular provides a novel acetylisovaleryltylosin tartrate premixing agent product as well as a preparation technology and application thereof. The novel acetylisovaleryltylosin tartrate premixing agent product is prepared from acetylisovaleryltylosin tartrate and various auxiliary materials including an anti-caking agent, an adsorbent, a bonding agent, a diluting agent and the like according to a certain ratio. The preparation technology of the novel acetylisovaleryltylosin tartrate premixing agent product comprises the following steps: 1) preparing materials; 2) crushing and sieving; 3) uniformly mixing; 4) pulping; and 5) drying and granulating. The novel acetylisovaleryltylosin tartrate premixing agentproduct and pig feed are mixed to feed; and the mixing amount accounts for 0.2 weight percent of the pig feed and the product is continuously fed for 7 days. The novel acetylisovaleryltylosin tartrate premixing agent product provided by the invention has high medicine availability, good animal compliance and a remarkable curative effect on sick pigs; and the novel acetylisovaleryltylosin tartratepremixing agent product has the advantages of simple production technology, convenience for production and utilization and small side effect and especially has a relatively good curative effect on prevention and treatment of cough and asthma, and clostridiosis welchii of the sick pigs.

Description

technical field [0001] The invention belongs to the related technical field of antibiotic products, and in particular relates to a new type of veterinary antibiotic tyvalancin premix, as well as the preparation process and application of the antibiotic. Background technique [0002] Tylosin (AIV for short, formerly known as acetylisovaleryl tylosin, also known as "super tylosin") is a semi-synthesized product obtained by biological fermentation on the basis of tylosin. A special macrolide antibiotic for poultry and livestock. It has antibacterial activity against most gram-positive bacteria and some gram-negative bacteria, including mycoplasma, vibrio, and spirochete. Prevention and treatment of atrophic rhinitis, fowl cholera, chicken chronic respiratory disease, bovine mycoplasma pneumonia and other diseases. The pharmacodynamic characteristics of tivalamectin determine that it plays a very important role in pig breeding. [0003] Limited by its physical and chemical pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K31/7048A61K47/46A61K47/44A61K47/26A61K47/10A61K47/36A61K47/02A61K47/12A61K47/20A61K47/32A61P31/04A61P11/06A61P1/12
CPCY02A40/70
Inventor 丁晓刚
Owner CHENGDU QIANKUN VETERINARY PHARMA
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