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Preparation method of goose parvovims and muscovy duckling parvovirus bivalent egg yolk antibody

A technology for Muscovy duck parvovirus and gosling plague virus, applied in the direction of antibodies, antiviral agents, antibody medical components, etc., can solve the problem of difficulty in preventing and controlling Muscovy duck gosling plague and Muscovy duck parvovirus disease at the same time, and achieve high protection rate effect

Inactive Publication Date: 2018-02-27
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The present invention aims at the technical defects of the prior art, and provides a method for preparing a double yolk antibody against gosling plague virus and muscovy duck parvovirus, so as to solve the problem that the yolk antibody in the prior art is difficult to simultaneously prevent and treat muscovy duck gosling plague and muscovy duck parvovirus. Technical Problems of Duck Parvovirus Disease

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 A preparation method of goose plague virus and Muscovy duck parvovirus dual yolk antibody

[0032] A preparation method of goose plague virus and Muscovy duck parvovirus dual yolk antibody, comprising the following steps:

[0033]1) Take goose plague virus GPV-HB strain to prepare goose plague inactivated vaccine; take muscovy duck parvovirus MDPV-FJ strain to prepare muscovy duck parvovirus inactivated vaccine; buy commercially available goose plague live vaccine and wait use;

[0034] 2) Get laying hens, inject the described gosling plague inactivated vaccine and gosling plague live vaccine respectively to carry out the basic immunization of gosling plague vaccine, inject the described muscovy duck parvovirus inactivated vaccine one week later to carry out the muscovy duck parvovirus vaccine For basic immunization, inject the inactivated vaccine against gosling plague and the live vaccine against gosling plague two weeks later for the first booster immuniza...

Embodiment 2

[0043] Embodiment 2 utilizes the yolk antibody prepared in embodiment 1 to carry out the effect of gosling plague, muscovy duck parvovirus disease treatment

[0044] 2000 7-day-old Muscovy ducks had gosling plague (accompanied by Muscovy duck parvovirus disease), and the yolk antibody prepared in Example 1 was used for treatment. The treatment method was: 2 mL / only for birds ≤ 21 days old Inject the yolk antibody into the pectoral muscle of the individual; inject the yolk antibody into the pectoral muscle of the poultry individual >21 days old at a dosage of 3 mL / bird. It was found that the epidemic was effectively controlled and the cure rate reached 94%.

Embodiment 3

[0045] Example 3 The effect of using the yolk antibody prepared in Example 1 to prevent gosling plague and Muscovy duck parvovirus disease

[0046] In the muscovy duck farm where the gosling plague occurred, 2 groups of Muscovy ducks (4000 in total, 7 days old) were selected for emergency prevention. The prevention method was: use 1mL / piece to treat poultry individuals ≤ 21 days old Inject the yolk antibody into the pectoral muscle; inject the yolk antibody into the pectoral muscle of poultry individuals > 21 days old at a dosage of 2 mL / bird. It was found that after the epidemic situation in the Muscovy duck farm was under control, the 4,000 Muscovy ducks did not suffer from single or mixed infection of gosling plague and Muscovy duck parvovirus, and the preventive protection rate reached 100%.

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Abstract

The invention provides a preparation method of a goose parvovims and muscovy duckling parvovirus bivalent egg yolk antibody. According to the technical scheme, an inactivated vaccine prepared from a goose parvovims GPV-HB strain and a market sold goose parvovims live vaccine are jointly used as a goose parvovims antigen; an inactivated vaccine prepared from muscovy duckling parvovirus MDPV-FJ strains is singly used as a muscovy duckling parvovirus antigen; the immune is totally performed for three times; the basic immune of the goose parvovims live vaccine and the self-made goose parvovims inactivated vaccine is performed once; the reinforced immune is performed twice; the interval between every two times is three weeks; the dose is 1ml / individual for each kind of vaccine in each time; theimmune times and the interval of the muscovy duckling parvovirus are identical to those of the goose parvovims, but the immune time is delayed for one week through being compared with that of the goose parvovims; the immune dose is 1ml / individual. Through the antigen and the immune measures, the valence of two antibodies in high-immunity eggs can reach the relatively high level. The egg yolk antibody prepared by the method provided by the invention can realize the simultaneous prevention and treatment on goose parvovims and muscovy duckling parvovirus diseases; the protection rate is very high.

Description

technical field [0001] The invention relates to the technical field of poultry biological products, and further relates to the preparation technology of egg yolk antibody, in particular to a method for preparing a dual egg yolk antibody against gosling plague virus and Muscovy duck parvovirus. Background technique [0002] Gosling plague is an acute or subacute septic infectious disease of goslings caused by Gosling plague virus (GPV), also known as gosling parvovirus. The disease mainly affects susceptible goslings aged 4 to 20 days, and has the characteristics of rapid transmission, high morbidity and mortality. As goslings age, their morbidity and mortality rates decrease. [0003] Comparative studies have found that the homology between isolates from different regions in China and between domestic and foreign isolates is high. Whether it is a structural protein or a non-structural protein, the nucleotide identity of the VP3 gene is more than 95%; the nucleotide sequence...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/08C07K16/02A61K39/42A61P31/20
CPCA61K2039/507A61K2039/545A61K2039/552A61K2039/70C07K16/02C07K16/081C07K2317/11C07K2317/31Y02A50/30
Inventor 刘冠星杨燚付旭彬郁宏伟梁武李守军
Owner TIANJIN RINGPU BIO TECH
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