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Preparation method of high-purity cannabidiol

A high-purity technology of cannabidiol, applied in the field of preparation of high-purity cannabidiol, can solve the problems of complex phenolic components and affecting the safety of CBD products

Active Publication Date: 2018-05-29
山东析木津健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The phenolic components in the plant cannabis are complex, and there are many components with similar polarities. Therefore, even if the above method uses the ethanol crystallization process to prepare CBD in CN106831353A, hallucinogenic or addictive components such as THC can still be detected in the product, affecting The safety of CBD products

Method used

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  • Preparation method of high-purity cannabidiol
  • Preparation method of high-purity cannabidiol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1. Preparation of high-purity CBD

[0023] ①Solvent extraction: take the top part of the hemp which accounts for about one-fifth of the whole plant, dry it and crush it into the coarsest powder, extract it three times with 95% ethanol as the solvent, and use 10 times the amount of solvent each time. The extracts were combined and filtered, dealcoholized under reduced pressure at 50°C until the solution was slightly cloudy, and cooled to room temperature.

[0024] ② Two-step column chromatography:

[0025] The first step of column chromatography: HPD-417 macroporous adsorption resin is used as the chromatography medium, and the column load is 5g medicinal material / mL resin. First eluted with 45% ethanol for 7 column volumes to wash away most of the polar impurities, and then eluted with 85% ethanol for 5 column volumes to elute the target components. Collect the eluate rich in target components, dealcoholize under reduced pressure at 50°C until the solution ...

Embodiment 2

[0028] Embodiment 2. Preparation of high-purity CBD

[0029] ①Solvent extraction: Take the top part of the hemp which accounts for about one-fifth of the whole plant, dry it and crush it into the coarsest powder, extract it three times with 95% ethanol as the solvent, and use 15 times the amount of solvent each time. The extracts were combined and filtered, dealcoholized under reduced pressure at 60°C until the solution was slightly cloudy, and cooled to room temperature.

[0030] ② Two-step column chromatography:

[0031] The first step of column chromatography: HPD-450 macroporous adsorption resin is used as the chromatography medium, and the column load is 3g medicinal material / mL resin. First eluted with 55% ethanol for 5 column volumes to wash away most of the polar impurities, and then eluted with 95% ethanol for 3 column volumes to elute the target components. Collect the eluate rich in target components, dealcoholize under reduced pressure at 60°C until the solution ...

Embodiment 3

[0034] Embodiment 3. Preparation of high-purity CBD

[0035] ①Solvent extraction: take the top part of the hemp which accounts for about one-fifth of the whole plant, dry it and crush it into the coarsest powder, extract it three times with 95% ethanol as the solvent, and use 20 times the amount of solvent each time. The extracts were combined and filtered, dealcoholized under reduced pressure at 70°C until the solution was slightly cloudy, and cooled to room temperature.

[0036] ② Two-step column chromatography:

[0037] The first step of column chromatography: AB-8 type macroporous adsorption resin is used as the chromatography medium, and the column load is 8g medicinal material / mL resin. First elute with 55% ethanol for 3 column volumes to wash away most of the polar impurities, and then use 95% ethanol for 3 column volumes to elute the target components. Collect the eluate rich in target components, dealcoholize under reduced pressure at 70°C until the solution is slig...

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Abstract

The invention belongs to the field of pharmaceutical and chemical industry, and specifically relates to a preparation method of high-purity cannabidiol. The preparation method is characterized by comprising the following steps: taking leaves of cannabis sativa and the plant top occupying one fifth of the whole plant as extraction parts, performing purification by using macroporous absorbent pillarchromatography and polyamide pillar chromatography joint technology, and performing crystallization refining by using a mixed solvent system, thereby maximally improving the yield in the premise of guaranteeing the acquisition of a high-purity product. According to the method provided by the invention, the CBD purity of the obtained product is high, the yield is high, the process is simple, and the industrialization is easy to realized.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to a preparation method of high-purity cannabidiol. Background technique [0002] Cannabis sativa Linn. is an annual herb of the genus Cannabis Linn. in the family Cannabinaceae. Its mature female plant flowers, leaves and stems are called Marijuana. At present, there are more than 80 kinds of cannabinoids (CBs) isolated from plant cannabis, mainly including tetrahydrocannabinol (tetrahydrocannabinol, THC), cannabidiol (CBD), cannabinol (cannabinol, CBN) and Cannabichromene (CBC), etc., among which THC and CBD have the highest content. [0003] THC is one of the important active ingredients in marijuana. It has good neuroprotective effect and can be used to treat vomiting caused by cancer. % of hemp varieties (i.e. industrial hemp) are allowed to be grown. [0004] CBD, which was isolated from marijuana in the 1940s, is another important active ingredient...

Claims

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Application Information

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IPC IPC(8): C07C37/70C07C37/84C07C39/23
CPCC07C37/004C07C39/23B01D15/1871B01D15/265B01J20/28085B01J20/285A61K31/05A61K36/185A61K2236/00B01D15/1864C07C37/82C07C37/84
Inventor 曲桂武崔明
Owner 山东析木津健康科技有限公司
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