Low-molecular chitosan @ silver nanoparticle compound film, and preparation method and applications thereof

A low-molecular-weight chitosan and silver nanoparticle technology, applied in the field of material science and engineering, can solve problems such as dispersibility and instability restricting applications, achieve strong antibacterial effect and bacterial retention ability, enhance antibacterial ability and moisture retention , Overcome the effect of poor water solubility

Active Publication Date: 2018-02-16
SOUTH CHINA INST OF COLLABORATIVE INNOVATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although nanosilver has excellent antibacterial properties, its dispersion and instability limit its application

Method used

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  • Low-molecular chitosan @ silver nanoparticle compound film, and preparation method and applications thereof
  • Low-molecular chitosan @ silver nanoparticle compound film, and preparation method and applications thereof
  • Low-molecular chitosan @ silver nanoparticle compound film, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: Preparation of Low Molecular Chitosan@Silver Nanoparticle Composite Membrane Material

[0050] Dissolve 4.00g chitosan in 200mL HAc-NaAc solution with pH=4.5, stir evenly to make it completely dissolved, add 0.20g papain, stir and react for 11.5 hours at a constant temperature of 45°C, heat up to 60°C constant temperature, and then add Added 40mL H 2 o 2 The solution was reacted for 30 minutes, heated at 100°C for 5 minutes, and cooled to room temperature naturally. The papain was removed by filtration, and the filtrate was precipitated with 4 times the volume of absolute ethanol to precipitate low-molecular-weight chitosan, which was separated by suction filtration and activated for 24 hours under vacuum conditions to obtain a sample and label it as LMWC-1.

[0051] Then, weigh 0.4762g of LMWC-1 sample and 9.5238g of polyvinyl alcohol into 90mL of deionized water, swell for 30 minutes to make it uniformly dispersed, and then add 1mL of 20mg / mL AgNPs disper...

Embodiment 2

[0052] Example 2: Preparation of Low Molecular Chitosan@Silver Nanoparticle Composite Membrane Material

[0053] Dissolve 4.00g chitosan in 200mL HAc-NaAc with pH = 4.5, stir evenly to dissolve completely, add 0.40g papain, stir and react at a constant temperature of 45°C for 11.5 hours, raise the temperature to 60°C constant temperature, and add to it Add 40mL H 2 o 2 The solution was reacted for 30 minutes, boiled in water bath for 5 minutes, and cooled to room temperature naturally. The papain was removed by filtration, and the filtrate was precipitated with 4 times the volume of absolute ethanol to precipitate the low-molecular-weight chitosan product, separated by suction filtration, and activated for 24 hours under vacuum conditions to obtain a sample and label it as LMWC-2. Weigh 0.4762g of LMWC-2 sample and 9.5238g of polyvinyl alcohol into 90mL of deionized water, swell for 30 minutes to make it evenly dispersed, and then add 1mL of 20mg / mL AgNPs dispersion (sonicat...

Embodiment 3

[0054] Example 3: Preparation of Low Molecular Chitosan@Silver Nanoparticle Composite Membrane Material

[0055] Dissolve 4.00g chitosan in 200mL HAc-NaAc with pH = 4.5, stir evenly to dissolve it completely, add 0.27g papain, stir and react at a constant temperature of 45°C for 11.5 hours, raise the temperature to a constant temperature of 60°C, and add to it Add 40mL H 2 o 2 The solution was reacted for 30 minutes, boiled in water bath for 5 minutes, and cooled to room temperature naturally. The papain was removed by filtration, and the filtrate was precipitated with 4 times the volume of absolute ethanol to precipitate low-molecular-weight chitosan, which was separated by suction filtration and activated for 24 hours under vacuum conditions to obtain a sample and label it as LMWC-3. Weigh 0.4762g of LMWC-3 and 9.5238g of polyvinyl alcohol into 90mL of deionized water, swell for 30 minutes to make it evenly dispersed, and then add 1mL of 20mg / mL AgNPs dispersion (cleaned b...

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Abstract

The invention belongs to the technical field of material science and engineering, and discloses a low-molecular chitosan @ silver nanoparticle compound film and a preparation method thereof and applications in the field of antibacteria and anti-corrosion. The preparation method of the invention comprises the following steps: adding enzyme powder into a buffer solution of macromolecular chitosan, conducting reaction with stirring for 10-14h at 30-60 DEG C, adding a H2O2 solution, conducting reaction at 50-80 DEG C for 20-60min, conducting heating for 5-10min at 90-110 DEG C, and conducting pumping filtration, separation, heating and activation to obtain a low-molecular chitosan final product; adding the low-molecular chitosan final product and polyvinyl alcohol into water, conducting uniform mixing, adding an AgNPs dispersion liquid, conducting stirring at 30-90 DEG C for 4-5h, and conducting stirring for 1-2h in a cell pulverizer to obtain an electrostatic spinning solution; and conducting spinning to obtain the low-molecular chitosan @ silver nanoparticle compound film. The compound film of the invention has excellent performance, has stronger antibacterial effects and bacteria interception capability, and can be applied to the fields of the antibacterial and the anti-corrosion.

Description

technical field [0001] The invention belongs to the field of material science and engineering technology, and in particular relates to a low-molecular-weight chitosan@silver nanoparticle composite film, its preparation method and its application in the antibacterial and antiseptic fields. Background technique [0002] With the progress of human beings, people place higher expectations on human health, and the safety standards for daily chemicals are getting higher and higher. As one of the indispensable additives in the daily chemical industry, preservatives have safety standards will also increase. Preservatives are generally divided into synthetic preservatives and natural preservatives. Synthetic preservatives are mostly used now, but long-term studies have found that some synthetic preservatives have problems such as carcinogenicity, teratogenicity, and poisoning. 2009 "Johnson & Johnson Toxic" incident: Johnson & Johnson's baby bathroom products were exposed to contai...

Claims

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Application Information

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IPC IPC(8): A23L3/3562A23L3/3571A23L3/358A61K8/19A61K8/73A61Q19/00A01N59/16A01N43/16A01N25/08A01N25/12A01P3/00A01P1/00
CPCA01N25/08A01N25/12A01N43/16A01N59/16A23L3/3562A23L3/3571A23L3/358A61K8/19A61K8/736A61K2800/524A61Q19/00
Inventor 程建华余林玲郑华生张鹏
Owner SOUTH CHINA INST OF COLLABORATIVE INNOVATION
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