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Novel external drug formula for treating acne and preparation method of formula

A formula and drug technology, applied in the field of medicine, can solve the problems of poor drug stability of acne, complex pharmaceutical composition components, poor treatment effect, etc., and achieve the problem of less impurities, fast dissolution rate, and good acne treatment. Effect

Inactive Publication Date: 2018-02-09
董又明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The medicine of this invention is used to treat acne, which can reduce the sebum secretion of sebaceous glands, inhibit the growth of bacteria in hair follicles, reduce skin inflammation, and promote the absorption and dissipation of red, swollen nodules at hair follicles, but the composition of the medicine is complex and easily causes side effects relapse, and the stability of the medicine for the treatment of acne prepared is not good, and the long-term treatment effect is poor

Method used

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  • Novel external drug formula for treating acne and preparation method of formula
  • Novel external drug formula for treating acne and preparation method of formula

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 cimetidine crystal

[0038] (1) Dissolve the cimetidine bulk drug in a mixed solution of methanol and ethanol, wherein the mass volume ratio of the cimetidine bulk drug to methanol and ethanol is 1g: 78ml: 84ml, heat to reflux, and form a a saturated solution;

[0039] (2) Divide the above solution into two cooling treatments, the first cooling to 40°C at a cooling rate of 6°C / min, the second cooling to 4°C at a cooling rate of 3°C / min, and then standing for 24 hours to precipitate white solid, filtered;

[0040] (3) Place the white solid in a vacuum desiccator to dry for 36 hours to obtain the cimetidine crystals.

[0041] The X-ray powder diffraction spectrum that cimetidine crystal uses Cu-Kα ray to measure is as figure 1 shown.

Embodiment 2

[0042] The preparation of embodiment 2 cimetidine crystals

[0043] (1) Dissolve the cimetidine bulk drug in a mixed solution of methanol and ethanol, wherein the mass volume ratio of the cimetidine bulk drug to methanol and ethanol is 1g: 80ml: 90ml, heat to reflux, and form a a saturated solution;

[0044] (2) Divide the above solution into two cooling treatments, the first cooling to 43°C at a cooling rate of 7°C / min, the second cooling to 5°C at a cooling rate of 4°C / min, and then standing for 26 hours Precipitate a white solid, filter;

[0045] (3) Place the white solid in a vacuum desiccator to dry for 42 hours to obtain the cimetidine crystals.

[0046]The X-ray powder diffraction spectrum obtained by measuring the obtained cimetidine using Cu-Kα rays is basically consistent with that of Example 1.

Embodiment 3

[0047] The preparation of embodiment 3 cimetidine crystals

[0048] (1) Dissolve the cimetidine bulk drug in a mixed solution of methanol and ethanol, wherein the mass volume ratio of the cimetidine bulk drug to methanol and ethanol is 1g: 83ml: 96ml, heat to reflux, and form a a saturated solution;

[0049] (2) Divide the above solution into two cooling treatments, the first cooling to 45°C at a cooling rate of 8°C / min, the second cooling to 6°C at a cooling rate of 5°C / min, and then standing for 28 hours to precipitate white solid, filtered;

[0050] (3) Place the white solid in a vacuum desiccator to dry for 48 hours to obtain the cimetidine crystals.

[0051] The X-ray powder diffraction spectrum obtained by measuring the obtained cimetidine using Cu-Kα rays is basically consistent with that of Example 1.

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Abstract

The invention discloses a novel external drug formula for treating acne and a preparation method of the formula. The formula comprises raw materials as follows: metronidazole, lincomycin, cimetidine and normal saline. The drug formula for treating acne is directly applied to skin, a patient does not need to take medicines or have an injection, and side effects caused by medicines during conventional application are reduced; the acne cure efficiency is higher, and the formula is convenient to use. The invention also provides a cimetidine crystal. The formula prepared from the cimetidine crystalhas better stability, is not prone to deterioration during long-time storage and has a better effect on treating the acne. The preparation method of the drug formula is simple, materials are easy toobtain and the cost is low.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a novel externally used medicinal formula for treating acne and a preparation method thereof. Background technique [0002] Acne, commonly known as whelk or pimples, is a common and frequently-occurring disease among young men and women. It tends to occur on the face, chest and back, and recurs. If it is not treated properly, uneven scars may appear on the face. The occurrence of acne is mainly closely related to factors such as excessive sebum secretion, pilosebaceous gland duct blockage, bacterial infection, and inflammatory response. After entering puberty, the level of androgen, especially testosterone, in the human body increases rapidly, which promotes the development of sebum and produces a large amount of sebum. At the same time, abnormal keratinization of the pilosebaceous duct causes duct blockage, sebum discharge obstruction, and the formation of keratin ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7056A61K31/4164A61P17/10C07D233/64
CPCA61K9/0014A61K31/4164A61K31/7056C07D233/64A61K2300/00
Inventor 董又明
Owner 董又明
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