Ethyl acetate based gradient extraction method for silymarin

Abstract

The invention relates to an extraction method for silymarin. The method is characterized by comprising steps as follows: silybum marianum seeds are added to a huller for hulling; silybum marianum hulls and ethyl acetate are added to pot group type gradient extraction equipment; the silybum marianum hulls are subjected to gradient extraction, and a primary extraction solution of silybum marianum isobtained; the primary extraction solution is concentrated, and a silybum marianum concentrated solution is obtained; aqueous alkali is added to the concentrated solution, and a mixed solution is stirred and left to stand for precipitation; precipitates are filtered, a product is dried, smashed and screened, and silymarin is obtained. According to the scheme, the gradient extraction is adopted, sothat extraction rate of silymarin is increased, and production energy consumption and production cost are reduced.

Description

technical field [0001] The embodiment of the present invention relates to a production method, in particular to a production method of silymarin. Background technique [0002] Silymarin is a mixture of flavonoid lignans derived from the seeds of the plant Silybum marianum in the family Asteraceae. Its main components include flavonoids such as silibinin, isosilibinin, dehydrosilibinin, silybinin and silybinin. Silymarin has the function of protecting the liver and promoting choleresis, and is mainly used for the treatment of liver diseases. Secondly, it also has obvious anti-lipid peroxidation, anti-radiation, scavenging free radicals, anti-gastric ulcer and other effects. It has good effects in reducing blood fat, preventing and treating atherosclerosis, preventing cerebral ischemia, and anti-platelet aggregation. Non-toxic, non-teratogenic and mutagenic. [0003] At present, there are two main extraction methods of silymarin, one is organic solvent extraction, and the ...

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Problems solved by technology

The problem with this method is that after the milk thistle seeds are crushed, the oil cannot be completely extracted, which will have a certain impact on the subsequent extraction purity of silymarin; another technique is to shell the milk thistle seeds first, and then use water Silymarin is extracted from silymarin shells to avoid the influence of oil in milk thistle seeds, but this method needs to be shelled separately, and the extraction process is not thorough. Milk thistle meal contains silymarin that has not been completely extracted. To obtain When the same amount of silymarin, increased extraction time cost and economic cost

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