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Compound composition for preventing or treating diabetic eye disease, its preparation method and application

A technology for diabetic ophthalmopathy and a composition, applied in the field of traditional Chinese medicine, can solve problems such as blindness, and achieve the effects of convenient administration, cheap and easy-to-obtain raw materials, and good effects

Active Publication Date: 2021-06-18
THE UNIVERSITY OF HONG KONG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Without timely diagnosis and reasonable treatment, it may eventually lead to blindness
At present, there is no effective and convenient drug to treat this pathological change.

Method used

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  • Compound composition for preventing or treating diabetic eye disease, its preparation method and application
  • Compound composition for preventing or treating diabetic eye disease, its preparation method and application
  • Compound composition for preventing or treating diabetic eye disease, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] The preparation of embodiment 1 Chinese medicine compound composition

[0051] (1) Add 500 g of Coptis chinensis into boiling water whose weight is 10 times the total weight of the medicinal materials, and decoct twice for 60 minutes each time, filter, combine the filtrates and concentrate to dryness to obtain 25 g of Coptis chinensis total extract.

[0052] The components of the total extract of Coptidis Rhizoma were analyzed by high performance liquid chromatography-mass spectrometry, and compared with standard samples. Table berberine and berberine and other berberine alkaloid compounds, the alkaloid compound accounted for 45% by weight of the total extract of Coptis chinensis.

[0053] The content of berberine in the total extract of Coptidis Rhizoma was determined by high performance liquid chromatography, and the weight content of berberine in the total extract of Coptidis Rhizoma was 26%.

[0054] Using the phenol-sulfuric acid colorimetric method (see Example...

Embodiment 2

[0057] The preparation of embodiment 2 Chinese medicine compound composition

[0058] (1) Add 500 g of Coptis chinensis into boiling water whose weight is 20 times the total weight of the medicinal materials and decoct 3 times for 120 minutes each time, filter, combine the filtrates and concentrate until dry to obtain 40 g of Coptis chinensis total extract.

[0059] The components of the total extract of Coptidis Rhizoma were analyzed by high performance liquid chromatography-mass spectrometry, and compared with standard samples. Table berberine and berberine alkaloid compounds such as berberine, the alkaloid compound accounted for 60% by weight of the total extract of Coptis chinensis.

[0060] The content of berberine in the total extract of Coptidis Rhizoma was determined by high performance liquid chromatography, and the weight content of berberine in the total extract of Coptidis Rhizoma was 38%.

[0061] Using the phenol-sulfuric acid colorimetric method, it is measur...

Embodiment 3

[0064] The preparation of embodiment 3 Chinese medicine compound composition

[0065] (1) Add 500 g of Coptis chinensis into boiling water whose weight is 15 times the total weight of the medicinal materials and decoct once for 90 minutes, filter, and concentrate the filtrate to dryness to obtain 15 g of Coptis chinensis total extract.

[0066] The components of the total extract of Coptidis Rhizoma were analyzed by high performance liquid chromatography-mass spectrometry, and compared with standard samples. Table berberine and alkaloid compounds such as berberine, the alkaloid compound accounts for 31% by weight of the total extract of Coptis chinensis. The weight percentage of the polysaccharide component in the total extract of Coptis chinensis is 19%. The content of berberine in the total extract of Coptidis Rhizoma was determined by high performance liquid chromatography, and the weight content of berberine in the total extract of Coptidis Rhizoma was 19%.

[0067] (2...

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Abstract

The invention provides a traditional Chinese medicine compound composition for preventing or treating diabetic eye disease, which comprises the total extract of Coptis chinensis and the extract of ginger, wherein the weight ratio of the total extract of Coptis chinensis and the extract of ginger is 4:1-1 :1. The invention also provides the preparation method and application of the traditional Chinese medicine compound composition. The present invention further provides the use of the total extract of Coptidis rhizome. The traditional Chinese medicine compound composition for preventing or treating diabetic eye disease of the present invention has cheap and easy-to-obtain raw materials, simple preparation method and convenient administration. The results of pharmacological studies show that the total extract of Coptis chinensis of the present invention has a significantly better effect than the total alkaloid mixture of Coptis chinensis on the prevention and treatment of type I and type II diabetic eye diseases, and the Chinese medicine compound composition of the present invention is obtained by combining the total extract of Coptis chinensis When used in combination with ginger extract, it also has a significantly improved effect of preventing and treating type I and type II diabetic eye diseases.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine. Specifically, the present invention relates to a compound traditional Chinese medicine composition for preventing or treating diabetic eye disease. The invention also relates to the preparation method and application of the traditional Chinese medicine compound composition, as well as the application of the total extract of Coptis chinensis. Background technique [0002] With the improvement of people's living standards, nutritional structure changes. Obesity and other metabolic diseases are gradually increasing, and the accompanying incidence of type II diabetes is getting higher and higher. At the same time, irregular living habits, fatigue, excessive smoking and drinking, and changes in environmental factors lead to changes in the human immune system and genetic structure, resulting in an increase in the number of cases of type I diabetes dominated by genetic factors. Research on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P3/10A61P9/10
Inventor 冯奕斌王宁
Owner THE UNIVERSITY OF HONG KONG
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