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Anorectal postoperative drug delivery apparatus based on PDMS micro-electromagnetism

A drug delivery device technology after anorectal surgery, applied in the medical field, can solve the problems of expensive equipment, large drug dosage, complicated operation, etc., and achieve the effects of curbing reverse leakage, preventing drug backflow, and soft drug delivery process

Active Publication Date: 2018-01-12
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, conventional anorectal medical drug delivery devices usually have problems such as excessive drug delivery (compared to nanoliters), slow drug response time (compared to milliseconds), complex operations, and expensive equipment, and cannot be administered anytime, anywhere. medicine
[0005] In addition, in view of the current development of microfluidic technology, the process of using microvalve drug delivery is: each time it is used, the drug reagent and buffer solution need to be injected into the drug inlet channel and drug delivery channel in advance, and then carried out by an external driving source. Injecting and administering medicine lacks integration, so it is also inconvenient to use
In addition, how to reduce the reverse leakage of the microvalve is also a problem, that is, due to the insufficient power of the micropump, the medicine is easy to flow back

Method used

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  • Anorectal postoperative drug delivery apparatus based on PDMS micro-electromagnetism
  • Anorectal postoperative drug delivery apparatus based on PDMS micro-electromagnetism
  • Anorectal postoperative drug delivery apparatus based on PDMS micro-electromagnetism

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Effect test

Embodiment 1

[0029] A postoperative drug delivery device based on PDMS micro-electromagnetic anorectal surgery provided by the present invention includes an overcoat 1, a drug delivery channel 2, a piezoelectric driver 3, a buffer pool 4, a drug feeding channel 5, an electromagnetic driver 6, a drug pool 9 and a normally closed microvalve10. The normally closed microvalve 10 is composed of a valve plate 7 and a valve plug 8, and adopts a zero-gap contact type PDMS planar microvalve structure, which can effectively control the flow direction of the liquid and reduce the reverse leakage of the liquid.

[0030] The right side of the overcoat 1 is connected to the drug delivery channel 2; the right side of the drug delivery channel 2 is a piezoelectric driver 3, and its two ends are respectively connected to the drug channel 2 and the buffer tank 4 through a normally closed microvalve 10; The lower part of the channel 2 is connected to the drug feeding channel 5 through a normally closed micro...

Embodiment 2

[0036] Such as Figure 5 As shown, a positive pressure and a negative pressure are respectively formed in the pump chamber 15, and the two easily resonate and cancel each other out, so that the net flow rate of the micropump is significantly reduced, which is not conducive to the outflow of the medicament. Therefore, in order to ensure sufficient propulsion It is necessary to optimize and strengthen the permalloy PDMS pump membrane to produce as large a deformation force as possible under a given magnetic field strength.

[0037] Taking the side length A of the pump membrane as the reference side length, the permalloy structure and position parameters B, C, and D were standardized. The Young's modulus of the permalloy sheet and the PDMS pump membrane were set as: 230GPa and 0.95MPa . The optimized data obtained after finite element analysis using CoMSOLMultiphysics are: the side length and height of the pump chamber 15 are selected as 5mm and 1800um, and the permalloy structu...

Embodiment 3

[0039] Such as Figure 8 As shown, the function of the PE film 1302 is to provide substrate support for the PDMS pump membrane 13, which is convenient for replacement or peeling off from the silicon wafer layer.

[0040] The copper ion layer 1305 is a layer of copper metal ions with a thickness of about 50um deposited on the PDMS film 1301 by electron beam sputtering, and its function is to ensure that there is enough space between the permalloy sheet 12 and the PDMS pump film 13. Excellent adhesion to prevent the electroplated permalloy sheet from falling off during the electroplating process.

[0041] The S1818 photoresist layer is a photoresist with a thickness of 20um, formed as Figure 8Permalloy plated area shown in (b).

[0042] The permalloy sheet 12 is a driving sheet with a thickness of about 20 um deposited on the electroplating area of ​​the PDMS film 1301 by an electroplating process.

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Abstract

The invention discloses an anorectal postoperative drug delivery apparatus based on PDMS micro-electromagnetism. The drug delivery apparatus comprises a jacket (1), a drug delivery passage (2), a piezoelectric actuator (3), a buffer tank (4), a drug feeding passage (5), an electromagnetic driver (6), a drug pool (9) and a normally closed micro-valve (10), wherein the normally closed micro-valve (10) is composed of a valve block (7) and a valve plug (8). The drug delivery passage (2) is connected to the right side of the jacket (1); the piezoelectric actuator (3) is arranged at the right side of the drug delivery passage (2), and two ends of the piezoelectric actuator (3) are connected to the drug delivery passage (2) and the buffer tank (4) by virtue of the normally closed micro-valve (10); the drug feeding passage (5) is connected to the lower side of the drug feeding passage (2) by virtue of the normally closed micro-valve (10); the electromagnetic driver (6) is connected to the lower side of the drug feeding passage (5); and the drug pool (9) is connected to the lower side of the electromagnetic driver (6) by virtue of the normally closed micro-valve (10). The drug delivery apparatus provided by the invention, with the adoption of the flat micro-valve structure, can overcome the multi-layer complex structure of an existing mechanical micro-pump and can also effectively inhibit reverse leakage of medicine liquid, so that a millisecond drug delivery requirement can be achieved; the drug delivery apparatus has the advantages that the drug delivery apparatus is convenient for symptomatic medication and soft in a medication process, the drug delivery apparatus is also capable of preventing reflux of drugs and impact of the drugs to an affected part, and the drug deliveryapparatus is convenient to carry, more concise and efficient and is low in cost.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a PDMS-based micro-electromagnetic postoperative drug delivery device for anorectal surgery. Background technique [0002] Anorectal diseases are frequently-occurring diseases, such as anal fistula, hemorrhoids, colon cancer and so on. Especially after the anal fistula operation, the low anal fistula is not directly sutured after incision, but medication is used to make it heal by second intention. Anorectal diseases have been perplexing human health for a long time, how to solve and treat these diseases has become an important topic facing the scientific community today, and it is a hot and difficult point in international research. Because the surgical site is easily contaminated by feces, defecation stimulation and other factors, it has a certain adverse effect on the quality of life of the postoperative patient and the healing of the wound surface, and complications such as...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M31/00
Inventor 任鹏涛张苑
Owner THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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