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A kind of preparation method of composite photothermal agent with photothermal effect

A photothermal effect and composite light technology, applied in the fields of material science and biomedicine, can solve problems such as hindering biological applications and weak photothermal absorption intensity, achieve good biocompatibility, improve photothermal effect, and experiment repeatability high effect

Active Publication Date: 2020-04-24
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Polydopamine (PDA) is an emerging photothermal material, which has been extensively studied due to its good biocompatibility and mild synthesis conditions, but its weak photothermal absorption hinders its further development. biological application

Method used

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  • A kind of preparation method of composite photothermal agent with photothermal effect
  • A kind of preparation method of composite photothermal agent with photothermal effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Preparation of polydopamine nanoparticles: Measure 18ml of deionized water and 8ml of ethanol in a 100ml single-mouth bottle, quickly add 0.6ml of concentrated ammonia water (mass fraction is about 25%) under weak magnetic stirring conditions, Stir for 30 minutes, weigh 0.1 g of dopamine hydrochloride, dissolve it in 2 ml of deionized water, and add it to the solution system. React at 30°C for 24h.

[0023] After the reaction was completed, a dialysis bag with a molecular weight cut-off of 14000D was selected for dialysis for three days to obtain a dispersion of polydopamine nanospheres.

[0024] (2) Add 5ml of the dispersion in (1) and 25ml of deionized water into a 100ml four-necked bottle, and stir magnetically. Weigh 0.0051g CuCl2.2H2O and disperse it in 1ml of deionized water, then add it dropwise into a four-neck flask under magnetic stirring conditions, and react at room temperature for 3h after the dropwise addition is completed. After the reaction was com...

Embodiment 2

[0029] (1) Preparation of polydopamine nanoparticles: Measure 18ml of deionized water and 8ml of methanol in a 100ml single-mouth bottle, quickly add 0.6ml of concentrated ammonia water (mass fraction is about 25%) under weak magnetic stirring conditions, Stir for 30 minutes, weigh 0.1 g of dopamine hydrochloride, dissolve it in 2 ml of deionized water, and add it to the solution system. React at 30°C for 24h. After the reaction was completed, a dialysis bag with a molecular weight cut-off of 14000D was selected for dialysis for three days to obtain a dispersion of polydopamine nanospheres.

[0030] (2) Add 10ml of the dispersion in (1) and 20ml of deionized water into a 100ml four-necked bottle, and stir magnetically. Weigh 0.0102g CuCl2.2H2O and disperse it in 1ml of deionized water, then add it dropwise into a four-neck flask under magnetic stirring conditions, and react at room temperature for 3h after the dropwise addition is completed. After the reaction was completed,...

Embodiment 3

[0033] (1) Preparation of polydopamine nanoparticles: Measure 18ml of deionized water and 8ml of propanol in a 100ml single-mouth bottle, quickly add 0.6ml of concentrated ammonia water (mass fraction is about 25%) under weak magnetic stirring conditions, and heat at 30°C Stir for 30 min under the condition, weigh 0.1 g of dopamine hydrochloride, dissolve it in 2 ml of deionized water, and add it into the solution system. React at 30°C for 24h. After the reaction was completed, a dialysis bag with a molecular weight cut-off of 14000D was selected for dialysis for three days to obtain a dispersion of polydopamine nanospheres.

[0034] (2) Add 5ml of the dispersion in (1) and 25ml of deionized water into a 100ml four-necked bottle, and stir magnetically. Weigh 0.0075g of CuSO4.5H2O and disperse it in 1ml of deionized water, then add it dropwise into a four-neck flask under the condition of magnetic stirring, and react at room temperature for 3h after the dropwise addition is co...

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Abstract

The invention discloses a preparation method of a clean composite photo-thermal agent with excellent photo-thermal effect; the preparation method includes the following steps: taking dopamine hydrochloride (DA) as a reaction monomer, taking water-soluble alcohol and deionized water as a mixed solvent, adding a proper amount of stronger ammonia water to adjust the pH of the solution, and then carrying out oxidation self polymerization full reaction to prepare polydopamine (PDA) nanoparticles having uniform particle size; dispersing the obtained PDA nanoparticles in a proper amount of deionized water to obtain a dispersion liquid, then mixing with a bivalent copper salt solution, and undergoing a complex reaction, to prepare a PDA-Cu<2+> complex; taking the obtained solution as a seed liquid, adding sulfide as a sulfur source, carrying out a full reaction under certain conditions, preparing composite microspheres with CuS loaded on PDA, then dialyzing to filter out unreacted small molecules, and thus obtaining a dispersion liquid of composite microspheres. The photo-thermal effect of the synthesized material is improved, moreover, the synthetic method is green, and the product is clean; meanwhile, the preparation method has high repeatability of experiments and is easy for subsequent promotion and application.

Description

technical field [0001] The invention relates to the fields of material science and biomedicine, in particular to a preparation method of a composite photothermal agent with photothermal effects. Background technique [0002] According to statistics, at present, cancer ranks the second highest among the total mortality of diseases in the world. The treatment of cancer has attracted widespread attention of scientists. Traditional cancer treatment methods include surgical treatment, drug therapy, gene therapy and so on. These treatments often have some defects, such as inevitable damage to normal tissues, drug resistance, treatment uncertainty and so on. [0003] Photothermal therapy (PTT), as a new non-invasive treatment method, has attracted great attention from the scientific community. This technology uses materials with high light-to-heat conversion efficiency, injects them into the living body, enriches them in the tumor area through the EPR effect, and then converts l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0052A61K2300/00
Inventor 徐祖顺熊雨轩李全涛刘佩阳哲喻一鸣刘梦颐
Owner HUBEI UNIV
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