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Isoindole alkaloid compound in purslane, and extraction and separation method of isoindole alkaloid compound

A technology for indole alkaloids and separation methods, which is applied in the field of isoindole alkaloids and their extraction and separation, can solve the problems of low structural novelty, and achieve the effects of environmentally friendly process methods, simple and fast operation methods

Active Publication Date: 2017-12-12
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

[0004] At present, most of the chemical components isolated from purslane are known, and their structural novelty is low. Therefore, further development and isolation of new compounds in purslane are urgently needed

Method used

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  • Isoindole alkaloid compound in purslane, and extraction and separation method of isoindole alkaloid compound
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  • Isoindole alkaloid compound in purslane, and extraction and separation method of isoindole alkaloid compound

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Embodiment 1

[0036] The invention provides an isoindole alkaloid compound, the molecular formula is C 28 h 23 NO 8 , the chemical structural formula is:

[0037]

[0038] The isoindole alkaloid compound is called Oleraisoindole according to the structure, and Table 1 is the NMR data of the isoindole alkaloid compound: the compound is respectively in two different solvents of MeOD and DMSO 1 H-NMR spectrum and 13 C-NMR spectral data.

[0039] Table 1: C 28 h 23 NO 8 NMR data in two different solvents, MeOD and DMSO, respectively.

[0040]

[0041]

[0042] see Figure 1-17 , the structure identification and deduction of Oleraisoindole, an isoindole alkaloid compound of the present invention.

[0043]Oleraisondole: yellow powder, easily soluble in methanol, insoluble, slightly soluble in water. After spotting the sample on the silica gel thin-layer plate, the spots of the dilute bismuth iodide potassium test solution are orange-red, suggesting that the compound is an alkal...

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Abstract

The invention relates to the field of extraction and separation of traditional Chinese medicines, in particular to an isoindole alkaloid compound which is extracted, separated and identified from purslane, and an extraction and separation method of the isoindole alkaloid compound. The new alkaloid compound has a molecular formula of C28H23NO8 and is named as Oleraisoindole. The invention also provides the extraction and separation method of the isoindole alkaloid compound; the method comprises the steps of sequentially extracting by means of water boiling, extracting by using ethyl acetate, carrying out silica gel column chromatography, purifying by using an octadecylsilyl medium-pressure column and Sephadex LH-20, and carrying out liquid phase separation. The isoindole alkaloid compound is identified by using ultraviolet (UV), infrared ray (IR), HR-ESI-TOF-MS, hydrogen-1 nuclear magnetic resonance (1H-NMR), carbon-13 nuclear magnetic resonance (13C-NMR) and a two-dimensional nuclear magnetic spectrum analysis method. The compound has potential anti-inflammatory activity, anti-tumor activity, and the like; the invention also provides the preparation method of the compound, thus providing a lead compound and a theoretical basis for development of new medicines and new components.

Description

technical field [0001] The invention belongs to the field of extraction and separation of traditional Chinese medicines, in particular to an isoindole alkaloid compound extracted, separated and identified from purslane medicinal material and an extraction and separation method thereof. Background technique [0002] Purslane (Portulaca oleracea L.), also known as longevity dish, horse amaranth, is a plant of the family Amaranthaceae. Purslane likes fertile soil, is resistant to drought and waterlogging, has strong vitality, is widely distributed, and is rich in resources, and it is more common in Northeast my country. Purslane can be used as both medicine and food, and it is one of the wild plants with the same origin of medicine and food designated by the Ministry of Health of my country. The 2015 edition of "The Pharmacopoeia of the People's Republic of China" records that the dried aerial part of purslane is used as medicine. It has the effects of clearing away heat and d...

Claims

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Application Information

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IPC IPC(8): C07D209/66A61K31/403A61P29/00A61P35/00A23L33/125
CPCA23L33/125A23V2002/00C07D209/66A23V2200/30A23V2250/21A23V2300/14
Inventor 英锡相迪迪尔·史蒂恩张文洁蒋明月
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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