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Preparation method of capric acid

A technology of n-decanoic acid and trifluoromethanesulfonate, applied in the field of n-decanoic acid preparation, which can solve the problems of high environmental requirements for fermentation enzyme activity, limited application range, harsh reaction conditions, etc.

Active Publication Date: 2017-12-08
合肥利夫生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] N-decanoic acid is the main by-product when producing lauric acid, its yield is 30% of lauric acid, its content is relatively small, usually used as a mixture with caprylic acid, this is mainly due to its separation difficulty, n-capric acid Separation and purification cause cost increase and limit its application range
[0004] In order to expand the source of n-decanoic acid, the transition metal catalyzed cross-coupling method and glucose fermentation method have been developed, but the reaction conditions are harsh, and the fermentation enzyme activity has high environmental requirements, which is not conducive to large-scale production.

Method used

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Examples

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Embodiment 1

[0065] A preparation method of n-decanoic acid comprises the following steps: hydrodeoxygenating substance A with hydrogen, trifluoromethanesulfonate and a hydrogenation catalyst to obtain n-decanoic acid.

Embodiment 2

[0067] A preparation method of n-decanoic acid, comprising the steps of: combining δ-furfuryl levulinic acid, palladium carbon, W(OTf) 6 , acetic acid, and in a hydrogen atmosphere, adjust the hydrogen pressure to 40atm, stir and heat up to 190°C, keep stirring for 12h, filter the filtrate, and distill under reduced pressure to obtain a solid; dissolve the solid in aqueous sodium hydroxide solution, add activated carbon for decolorization, Filter to get the filtrate, adjust the pH to be less than 2 with hydrochloric acid, filter to get the filter cake, dry to obtain n-decanoic acid, wherein, δ-furfuryl levulinic acid, W(OTf) 6 The molar ratio of palladium element in palladium carbon to δ-furfuryl levulinic acid is 1:200.

Embodiment 3

[0069] A preparation method of n-decanoic acid, comprising the steps of:

[0070] Mix sodium hydroxide and levulinic acid aqueous solution, heat to reflux, add furfural methanol solution dropwise, reflux and stir for 1 h, acidify with 5wt% hydrochloric acid aqueous solution, filter to take filter cake, wash with ice water, and recrystallize in hot water to obtain δ-furfuryl levulinic acid, wherein the molar ratio of levulinic acid to furfural is 5:3, and the molar ratio of sodium hydroxide to levulinic acid is 1.1:1;

[0071] δ-furfuryllevulinic acid, platinum carbon, Zr(OTf) 4 , acetic acid, and in a hydrogen atmosphere, adjust the hydrogen pressure to 100 atm, stir and heat up to 120 ° C, keep stirring for 48 hours, filter the filtrate, and distill under reduced pressure to obtain a solid; dissolve the solid in aqueous sodium hydroxide solution, add activated carbon for decolorization, Take the filtrate by filtration, adjust the pH to be less than 2 with hydrochloric acid, ...

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Abstract

The invention discloses a preparation method of capric acid. The preparation method comprises the following steps: carrying out hydrodeoxygenation on a substance A and hydrogen, trifluoromethanesulfonic acid and a hydrogenation catalyst so as to obtain capric acid. According to the preparation method, the atom economy is good, the product yield is high, the product purity is high, the pollution to the environment is slight, the process route is simple, the operation is convenient, and the preparation method is suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to the technical field of chemical substance preparation, in particular to a preparation method of n-decanoic acid. Background technique [0002] N-capric acid is a medium-chain saturated fatty acid, which exists in a small amount in milk and goat milk, and is found in tropical oils such as coconut oil (n-capric acid content is about %) etc. are relatively high in content. N-decanoic acid and its esters are mainly used in food, plastic additives, medicine, pesticide, chemical and aviation industries, and can be used as flavors, food additives, lubricants, wetting Agents, plasticizers, foaming agents, antirust agents, polymer modifiers, high and low temperature special oils, aviation oils, etc., have a wide range of applications and a very promising market prospect. [0003] N-decanoic acid is the main by-product when producing lauric acid, its yield is 30% of lauric acid, its content is relatively small, usually used as a mixtur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/09C07C51/347C07C53/126C07D307/54
CPCC07C51/09C07C51/347C07D307/54C07C53/126
Inventor 邓晋谢中玉李兴龙徐海彭浩
Owner 合肥利夫生物科技有限公司
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