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Application of rhodiola rosea oligomer procyanidine in preparing medicine for treating atherosclerosis disease

A kind of Rhodiola oligomeric proanthocyanidin and oligomeric proanthocyanidin technology, which is applied in the application field of Rhodiola rosea

Inactive Publication Date: 2017-12-08
HEBEI AGRICULTURAL UNIV.
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, there are relatively few studies on Rhodiola oligomeric proanthocyanidins at home and abroad.

Method used

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  • Application of rhodiola rosea oligomer procyanidine in preparing medicine for treating atherosclerosis disease
  • Application of rhodiola rosea oligomer procyanidine in preparing medicine for treating atherosclerosis disease
  • Application of rhodiola rosea oligomer procyanidine in preparing medicine for treating atherosclerosis disease

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Experimental program
Comparison scheme
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Embodiment Construction

[0019] 1.1 Experimental materials

[0020] Rhodiola rosea oligomeric proanthocyanidins (OPCRR) is extracted from Rhodiola rosea rhizome powder with reference to our laboratory preparation patent (CN102229592B).

[0021] 1.2 Experimental animals

[0022] Wistar rats, male, 8 weeks old, weighing 160-180 g. purchased from Beijing Weitong Lihua Experimental Animal Center. 12h light / 12h dark, room temperature 24±1℃, humidity 50-60%, ventilation, anti-noise control.

[0023] 1.3 Main reagents and equipment

[0024] Vitamin D3, Propylthiouracil, Sodium deoxycholate, Cholesterol Beijing Soleibo Technology Co., Ltd.; total cholesterol (TC) test kit, total monoglyceride (triglyceride, TG) test kit, low density Lipoprotein cholesterol (low density lipoprotein cholesterol, LDL-C) test kit, high density lipoprotein cholesterol (high density lipoprotein cholesterol, HDL-C) test kit, very low density lipoprotein cholesterol (VLDL-C) Test kit, malondialdehyde (malondialdehyde, MDA) test ...

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Abstract

The invention provides application of rhodiola rosea oligomer procyanidine in preparing a medicine for treating atherosclerosis diseases, application in preparing medicines for reducing serum fat, application in preparing medicines for reducing serum oxidative stress, application in preparing medicines for relaxing blood vessels and application in preparing medicines for treating fatty livers. Experiment results show that the rhodiola rosea oligomer procyanidine has an effect similar to that of curcumin in relieving atherosclerosis and fatty livers of rats suffering from atherosclerosis, has an effect similar to the curcumin in improving serum of rats suffering from atherosclerosis and blood lipid metabolism of livers, has an effect similar to the curcumin in improving serum oxidative stress of the rats suffering from atherosclerosis, and has an effect similar to the curcumin in improving serum nitric oxide systems of the rats suffering from atherosclerosis.

Description

technical field [0001] The invention belongs to the field of Rhodiola rosea application technology, and in particular relates to the application of Rhodiola rosea oligomeric proanthocyanidins in the preparation of medicines for treating atherosclerotic diseases. Background technique [0002] Atherosclerosis (Atherosclerosis, AS) is a very complex chronic disease, manifested as lipid accumulation, thickening of arterial vessel wall and increase of certain inflammatory cytokines. Cardiovascular and cerebrovascular diseases with AS as an important pathological basis have extremely high morbidity and mortality, and have become one of the major diseases that threaten human health. In the United States, the mortality rate of cardiovascular disease and cerebrovascular disease ranks first and third in the total mortality rate respectively. The 2011 health report submitted by the US Centers for Disease Control pointed out that in 2006, the number of cardiovascular deaths accounted f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/353A61P9/10A61P3/06A61P9/08A61P1/16
CPCA61K31/353A61K36/41
Inventor 周茜赵文韩雪白冰瑶闫晨静董小涵
Owner HEBEI AGRICULTURAL UNIV.
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