Ginseng and rhizoma curculiginis tablet film coating premixed agent, preparation method thereof and ginseng and rhizoma curculiginis tablet coating method

Abstract

The invention discloses a ginseng and rhizoma curculiginis tablet film coating premixed agent. The ginseng and rhizoma curculiginis tablet film coating premixed agent consists of, by weight, 5-10 parts of hydroxypropyl methylcellulose, 2-10 parts of pharmaceutical gelatin, 2-5 parts of polyvinylpyrrolidone vinyl acetate copolymer, 1-5 parts of polyethylene glycol, 1-2 parts of tween 80, 1-5 parts of talcum powder, 1-4 parts of titanium dioxide and 1-10 parts of colorant. The ginseng and rhizoma curculiginis tablet film coating premixed agent has the advantages of being resistant to moisture, light and abrasion and taste-masking, splinters, speckles and mildew spots can not be generated easily, the validity period of a drug is prolonged, the application range of patients is widened, and sugar-avoiding patients and diabetes patients can also take ginseng and rhizoma curculiginis tablets coated with the agent on a long-term basis.

Description

technical field [0001] The invention relates to a coating agent, in particular to a film coating premix of Shenxian Tablets, a preparation method thereof and a coating method of Shenxian Tablets. Background technique [0002] Shenxian Tablet is a Chinese patent medicine used for warming the kidneys and nourishing the essence, nourishing qi and nourishing the blood. It is especially suitable for symptoms such as weakness of the waist and knees caused by kidney yin and yang deficiency and heart qi deficiency. The ginseng tablets currently on the market are generally sugar-coated tablets, but sugar-coated tablets will increase the weight of the tablet core by 50-100%. Long-term use will cause great harm to the human body, especially for patients who avoid sugar and diabetes. In addition, the dust generated during the syrup coating production process is very easy to pollute the environment, and each preparation process needs to use a large space in the clean area, such as sugar ...

AI Technical Summary

Problems solved by technology

The ginseng tablets currently on the market are generally sugar-coated tablets, but sugar-coated tablets will increase the weight of the tablet core by 50-100%. Long-term use will cause great harm to the human body, especially for patients who avoid sugar and diabetes

In addition, the dust generated during the syrup coating production process is very easy to pollute the environment, and each preparation process needs to use a large space in the clean area, such as sugar melting, gelatinization, adding pigments, drying sheets, and material storage, and the production process is complicated. , most of the operation process relies on the experience of the operator, which does not conform to the Good Manufacturing Practice (GMP)

In addition, due to many uncontrollable factors in the coating process of syrup, especially in the production and storage process of Chinese patent medicines with strong hygroscopicity, it is particularly prone to slivers, flower spots, mildew spots, disintegration overtime, difficult to store, Many defects such as decreased content, long production time and long drying time

[0003] Film-coating Shenxian Tablets with film-coating premixes available on the market has disadvantages such as poor adhesion, strong hygroscopicity, and easy cracks on the surface.

The water-based film coating premixed auxiliary materials are not ideal in moisture resistance and crack resistance, and cannot solve the unstable quality caused by moisture absorption, which brings great quality hidden dangers to the product

Non-aqueous film coating premixed excipients must use organic solvents, so the coating workshop has to consider adding anti-riot facilities, which is not environmentally friendly and significantly increases the cost of solvents

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