External use emplastrum for treating rheumatism and relieving pain

A technology for relieving dampness and relieving pain and applying plasters, applied in the field of external plasters, which can solve the problems of difficult volatilization of active ingredients, unsatisfactory drug efficacy, and poor pertinence, and achieve the effects of relieving rheumatism pain, good transdermal absorption rate, and easy absorption

Active Publication Date: 2017-12-05
杭州仁德药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of poor pertinence and unsatisfactory drug efficacy of some plasters, the purpose of the present invention is to provide an external plaster for eliminating dampness and relieving pain, which has a very obvious effect of eliminating dampness and relieving pain, and has a good transdermal absorption rate , quick effect, the active ingredients in the plaster are not easy to volatilize, the plaster has good viscosity and uniform quality

Method used

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  • External use emplastrum for treating rheumatism and relieving pain
  • External use emplastrum for treating rheumatism and relieving pain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] An external plaster for relieving dampness and relieving pain, prepared from the following components: musk 5g, camphor 2000g, sustained release agent 5000g, capsicum liquid extract 1500g, belladonna liquid extract 600g, methyl salicylate 800g 130g of diphenhydramine hydrochloride, 7600g of zinc oxide, 2400g of petrolatum, 6400g of rosin, 800g of lanolin, 200g of transdermal accelerator, 160g of tackifier, 100g of emulsifier, and 6800g of rubber.

[0034] Wherein the sustained-release agent is preferably nanoscale coconut shell activated carbon, the transdermal accelerator includes a main agent and an auxiliary agent, the mass percentage of the main agent is 55%, and the main agent is N,N-dimethylaminoisopropionic acid lauryl ester and The combination of ferulic acid, the mass ratio of N,N-dimethylaminoisopropionic acid dodecyl ester to ferulic acid is 1:0.3, the auxiliary agent is cocamidopropyl betaine, and the viscosity enhancer is preferably nano di For silica airge...

Embodiment 2

[0045] An external plaster for relieving dampness and relieving pain, prepared from the following components: musk 12.5g, camphor 2500g, sustained release agent 625g, capsicum liquid extract 1875g, belladonna liquid extract 750g, methyl salicylate 1000g, diphenhydramine hydrochloride 157.5g, zinc oxide 9000g, petrolatum 3000g, rosin 8000g, lanolin 1000g, skin penetration enhancer 250g, tackifier 200g, emulsifier 150g, rubber 8500g.

[0046] Wherein the sustained-release agent is preferably nanoscale coconut shell activated carbon, the transdermal accelerator includes a main agent and an auxiliary agent, the mass percentage of the main agent is 70%, and the main agent is N,N-dimethylaminoisopropionic acid lauryl ester and Combination of α-bisabolyl alcohol, the mass ratio of N,N-dimethylaminoisopropionate dodecyl to α-bisabolyl alcohol is 1:0.7, and the auxiliary agent is trioctylmethyl chloride ammonium, the tackifier is preferably nano-silica aerogel, and the emulsifier is pr...

Embodiment 3

[0057] An external plaster for relieving dampness and relieving pain, prepared from the following components: musk 20g, camphor 3000g, sustained release agent 750g, capsicum liquid extract 2250g, belladonna liquid extract 900g, methyl salicylate 1200g 185g of diphenhydramine hydrochloride, 10400g of zinc oxide, 3600g of petrolatum, 9600g of rosin, 1200g of lanolin, 300g of transdermal accelerator, 240g of tackifier, 200g of emulsifier, and 10200g of rubber.

[0058] Wherein the sustained-release agent is preferably ethyl cellulose, the transdermal enhancer includes a main agent and an auxiliary agent, the mass percentage of the main agent is 85%, and the main agent is N,N-dimethylaminoisopropionic acid dodecyl ester and glycerin Monohexyl ether, the mass ratio of dodecyl N,N-dimethylaminoisopropionate to glycerol monohexyl ether is 1:1.3, the auxiliary agent is cocamidopropyl betaine, and the tackifier is preferably nano-dioxide Silica airgel, preferably phosphatidylserine.

...

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Abstract

The invention belongs to the technical field of an emplastrum preparation, and particularly relates to external use emplastrum for treating rheumatism and relieving pain. The external use emplastrum for treating rheumatism and relieving pain is prepared from musk, camphor, a sustained release agent, capsicum extractum, atropa belladonna extractum, methyl salicylate, diphenhydramine hydrochloride, zinc oxide, vaseline, rosin, wool fat, transdermal penetration enhancers, tackifiers, emulsification promoters and rubber; and the sustained release agent is one kind of materials from nanometer grade cocoanut active charcoal, silane coupling agent modified silica micro powder or ethyl cellulose. The external use emplastrum for treating rheumatism and relieving pain has the very obvious effects for treating rheumatism and relieving pain; meanwhile, the good percutaneous absorption rate is realized; the effect taking speed is high; active ingredients in the emplastrum are not volatile; the stickiness of the emplastrum is good; the quality is unique; meanwhile, in the preparation, the materials are firstly prepared into emulsion slurry; and then, glue coating is performed, so that the ingredients of the external use emplastrum can be more easily absorbed by the skin.

Description

technical field [0001] The invention belongs to the technical field of plaster preparations, in particular to an external plaster for eliminating dampness and relieving pain. Background technique [0002] Plasters have a long history of application in our country. Vegetable or animal oils are added to make a jelly-like substance, which can be pasted on the affected area for a long time on one side of cloth, paper or leather. The medicine in the plaster is directly applied to the acupuncture points on the body surface. , the property of the medicine permeates the subcutaneous tissue from the surface to the inside through the fur. On the one hand, the relative advantage of the drug concentration is produced locally. So as to exert the greatest systemic pharmacological effect. Traditional injection and oral therapy damage nerves, blood vessels, muscles and other tissues, making it difficult for patients to accept, and these methods are easy to disperse the medicine through the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/70A61K47/04A61K47/38A61K47/24A61K47/18A61P29/00A61K31/125A61K31/135A61K31/618A61K35/55
CPCA61K9/0002A61K9/7076A61K31/125A61K31/135A61K31/618A61K35/55A61K36/81A61K47/02A61K47/183A61K47/186A61K47/24A61K47/38A61K2300/00
Inventor 俞帮和徐明蒋志刚汪海涛
Owner 杭州仁德药业股份有限公司
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