A kind of preparation method of external plaster for expelling rheumatism

A technology for expelling wind-dampness and plastering, which is applied in the field of preparation of external plaster, and can solve the problems of unsatisfactory drug effect, poor pertinence, and difficult volatilization of active ingredients.

Active Publication Date: 2021-05-04
杭州仁德药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problems of poor pertinence and unsatisfactory drug efficacy of some plasters, the object of the present invention is to provide a preparation method of an external plaster for expelling rheumatism, and the plaster prepared by the method has a very obvious effect of treating rheumatism pain At the same time, it has good transdermal absorption rate, quick effect, the active ingredients in the plaster are not easy to volatilize, the plaster has good viscosity and uniform quality

Method used

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  • A kind of preparation method of external plaster for expelling rheumatism
  • A kind of preparation method of external plaster for expelling rheumatism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method for an external plaster for expelling rheumatism, comprising the following steps:

[0031] (1) Rubber production: Cut 181.8g of rubber into 12cm-long rubber strips after removing the film, put them in the rubber mixing machine and roll to obtain 0.4mm thick rubber flakes, and then add gasoline with 5.3 times the weight of the rubber flakes in the mixer The solvent is soaked at 10°C to fully swell and soften the rubber sheet. The soaking time is not less than 24 hours, preferably 24 hours. The gasoline solvent is preferably mixed with No. 120 gasoline and ethanol, and the volume percentage of No. 120 gasoline is 75%;

[0032] (2) Ingredients: add 10g of menthol, 20g of camphor, 15g of methyl salicylate, 10g of borneol, and 163.6g of rosin into ethanol and stir evenly, then add 23g of compound absorption enhancer, 7g of zinc oxide, and Aconitum aconiti Fluid extract 50g, belladonna fluid extract 30g, rue extract 12.5g, vaseline 27.3g stir to obtain th...

Embodiment 2

[0042] A preparation method for an external plaster for expelling rheumatism, comprising the following steps:

[0043] (1) Rubber production: Cut 227.4g of rubber into 16cm-long rubber strips after removing the film, put them in the rubber mixing machine and roll them to obtain 1.1mm thick rubber flakes, and then add gasoline with 8 times the weight of the rubber flakes in the mixer The solvent is soaked at 15°C to fully swell and soften the rubber sheet. The soaking time is not less than 24 hours, preferably 36 hours. The gasoline solvent is preferably mixed with No. 120 gasoline and ethanol, and the volume percentage of No. 120 gasoline is 90%;

[0044] (2) Ingredients: 12.5g of menthol, 25g of camphor, 19g of methyl salicylate, 12.5g of borneol, and 204.5g of rosin were added to ethanol in turn and stirred evenly, and then 34g of compound absorption-promoting agent, 9g of zinc oxide, raw Aconitum aconitum liquid extract 62.5g, belladonna liquid extract 37.5g, rue extract 15...

Embodiment 3

[0054] A preparation method for an external plaster for expelling rheumatism, comprising the following steps:

[0055] (1) Rubber production: Cut 250.8g of rubber into 18cm-long rubber strips after removing the film, put them in the rubber mixing machine and roll them to obtain 1.6mm thick rubber flakes, and then add gasoline with 9.3 times the weight of the rubber flakes in the mixer The solvent is soaked at 18°C ​​to fully swell and soften the rubber sheet. The soaking time is not less than 24 hours, preferably 40 hours. The gasoline solvent is preferably mixed with No. 120 gasoline and ethanol, and the volume percentage of No. 120 gasoline is 90%;

[0056] (2) Ingredients: 13.8g of menthol, 27.5g of camphor, 21g of methyl salicylate, 13.8g of borneol, and 225g of rosin were added to ethanol and stirred evenly, and then 39.5g of compound absorption-promoting agent, 10g of zinc oxide, Aconitum aconitum liquid extract 68g, belladonna liquid extract 42g, rue extract 17g, vaseli...

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Abstract

The invention belongs to the technical field of plaster preparations, and in particular relates to a preparation method of an external plaster for expelling rheumatism, comprising the following steps: cutting rubber into strips, rolling into rubber flakes, and then placing them in gasoline solvent for swelling and emulsification , and then add each raw material into the gasoline solvent soaked in rubber flakes, stir evenly, filter to make a glue, and after high-speed homogenization, coat it on the backing to make a paste, and then reel, cover and seal. The plaster prepared by the preparation method of the external plaster for expelling rheumatism of the present invention has a very obvious effect of treating rheumatism pain, and at the same time has a good transdermal absorption rate, quick effect, the active ingredients in the plaster are not easy to volatilize, the plaster has good viscosity, and the quality is uniform .

Description

technical field [0001] The invention belongs to the technical field of plaster preparations, and in particular relates to a preparation method of an external plaster for expelling rheumatism. Background technique [0002] Plasters have a long history of application in our country. Vegetable or animal oils are added to make a jelly-like substance, which can be pasted on the affected area for a long time on one side of cloth, paper or leather. The medicine in the plaster is directly applied to the acupuncture points on the body surface. , the property of the medicine permeates the subcutaneous tissue from the surface to the inside through the fur. On the one hand, the relative advantage of the drug concentration is produced locally. So as to exert the greatest systemic pharmacological effect. Traditional injection and oral therapy damage nerves, blood vessels, muscles and other tissues, making it difficult for patients to accept, and these methods are easy to disperse the med...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61K9/70A61K47/02A61K47/44A61K47/24A61K47/18A61K47/12A61K47/10A61P29/00A61K31/045
CPCA61K9/7076A61K31/045A61K36/126A61K36/185A61K36/23A61K36/232A61K36/238A61K36/27A61K36/324A61K36/328A61K36/538A61K36/54A61K36/56A61K36/61A61K36/714A61K36/81A61K36/899A61K36/906A61K36/9068A61K47/10A61K47/12A61K47/18A61K47/24A61K2300/00
Inventor 俞帮和徐明蒋志刚汪海涛
Owner 杭州仁德药业股份有限公司
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