Extraction method and application of Manyprickle Acathopanax Root polysaccharides having anti-radiation and anti-ageing activity

A polysaccharide and anti-aging technology of Acanthopanax senticosus, which is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, preparations for skin care, etc., and can solve the problems of the extraction method of Acanthopanax senticosus residues and the lack of retrieval of patent applications, etc., To achieve the effect of enhancing activity, reducing content and stable product performance

Inactive Publication Date: 2017-11-24
GUANGZHOU JUZHU GENERAL TECH INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the research on Acanthopanax is mainly focused on the efficacy of the ingredients, and there are no relevant records on the extraction method and patent application of Acanthopanax residue

Method used

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  • Extraction method and application of Manyprickle Acathopanax Root polysaccharides having anti-radiation and anti-ageing activity
  • Extraction method and application of Manyprickle Acathopanax Root polysaccharides having anti-radiation and anti-ageing activity
  • Extraction method and application of Manyprickle Acathopanax Root polysaccharides having anti-radiation and anti-ageing activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A method for preparing Acanthopanax polysaccharides with anti-radiation and anti-aging activity, comprising the following processes:

[0026] (1) Dried the remaining residue after ethanol extraction of Acanthopanax senticosus at 40°C until the quality was constant, crushed and passed through an 80-mesh sieve, soaked in ether for one day and then evaporated to dry to obtain the residue powder of Acanthopanax senticosus residue;

[0027] (2) Take Acanthopanax residue powder, add 20 times of deionized water, and add 2.5% protease, carry out constant temperature water bath extraction at 80° C. for 8 hours to obtain Acanthopanax residue extract;

[0028] (3) Mix the chloroform and n-butanol mixture of Acanthopanax senticosus residue extract with equal volume volume ratio of 4:1 and place overnight, and collect the Acanthopanax senticosus polysaccharide solution in the lower layer after separating impurities;

[0029] (4) Acanthopanax senticosus polysaccharide liquid was conc...

Embodiment 2

[0031] A method for preparing Acanthopanax polysaccharides with anti-radiation and anti-aging activity, comprising the following processes:

[0032] (1) Dried the remaining residue after alcohol extraction of Acanthopanax senticosus at 35°C until the quality was constant, crushed and passed through a 70-mesh sieve, soaked in ether for one day and then evaporated to dry to obtain the residue of Acanthopanax senticosus residue powder;

[0033] (2) Take Acanthopanax residue powder, add 20 times of deionized water, and add 0.3% protease, carry out constant temperature water bath extraction at 80° C. for 8 hours to obtain Acanthopanax residue extract;

[0034] (3) Mix the chloroform and n-butanol mixture of Acanthopanax senticosus residue extract with equal volume volume ratio of 4:1 and place overnight, and collect the Acanthopanax senticosus polysaccharide solution in the lower layer after separating impurities;

[0035] (4) Acanthopanax senticosus polysaccharide liquid was conce...

Embodiment 3

[0037] A method for preparing Acanthopanax polysaccharides with anti-radiation and anti-aging activity, comprising the following processes:

[0038] (1) Dried the remaining residue after ethanol extraction of Acanthopanax senticosus at 45°C until the quality was constant, crushed and passed through a 90-mesh sieve, soaked in ether for one day and then evaporated to dry, to obtain Acanthopanax senticosus residue powder;

[0039] (2) Take Acanthopanax residue powder, add 20 times of deionized water, and add 5% protease, carry out constant temperature water bath extraction at 80° C. for 8 hours to obtain Acanthopanax residue extract;

[0040] (3) Mix the chloroform and n-butanol mixed solution of the Acanthopanax senticosus residue extract with an equal volume ratio of 4:1 and place it overnight, and collect the Acanthopanax senticosus polysaccharide solution in the lower layer after separating the impurities;

[0041] (4) Acanthopanax senticosus polysaccharide liquid was concent...

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Abstract

The invention discloses an extraction method and an application of Manyprickle Acathopanax Root polysaccharides having anti-radiation and anti-ageing activity. The extraction method comprises the following steps: 1, drying Manyprickle Acathopanax Root residues, crushing and sieving the dried residues, immersing the sieved residues in ether for 1 day, and volatilizing the ether to obtain Manyprickle Acathopanax Root residue powder; 2, taking the Manyprickle Acathopanax Root residue powder, adding deionized water, adding protease, and carrying out constant-temperature water bath extraction to obtain Manyprickle Acathopanax Root residue extract; 3, uniformly mixing the Manyprickle Acathopanax Root extract with an organic extractant according to a volume ratio of 1:1, standing the obtained solution overnight, separating impurities, collecting a Manyprickle Acathopanax Root polysaccharide liquid positioned at a lower layer; and 4, taking the Manyprickle Acathopanax Root polysaccharide liquid, carrying out reduced pressure concentration, precipitating the obtained concentrate with ethanol, taking the obtained precipitate, and further concentrating the precipitate to obtain the Manyprickle Acathopanax Root polysaccharides. The Manyprickle Acathopanax Root polysaccharides can enhance the activity of antioxidant enzymes, so the Manyprickle Acathopanax Root polysaccharides has an anti-oxidation effect; and the Manyprickle Acathopanax Root polysaccharides can reduce the content of a lipid peroxidation product malondialdehyde, so damages brought by ultraviolet irradiation are reduced.

Description

technical field [0001] The invention relates to the field of cosmetics, in particular to an extraction method and application of Acanthopanax polysaccharides with anti-radiation and anti-aging activities. Background technique [0002] Acanthopanax is the dried root and rhizome of the Araliaceae plant Acanthopanax. The stems and leaves can also be used for medicine, also known as Acanthopanax. Acanthopanax has a variety of components, including eleutheroside, eleuthero polysaccharide, eleuthero protein, eleuthero flavonoids and so on. It has anti-damage, anti-aging, anti-radiation and anti-fatigue effects. [0003] Since glycosides have poor solubility and stability in water and are easily hydrolyzed, the conventional method for extracting eleutherosides is alcohol extraction. However, the polysaccharides of Acanthopanax senticosus have poor alcohol solubility. When using the alcohol extraction method to extract the saponins of Acanthopanax senticosus, a large amount of pol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K8/73A61Q17/04A61Q19/08
CPCC08B37/0003A61K8/73A61K2800/78A61Q17/04A61Q19/08
Inventor 不公告发明人
Owner GUANGZHOU JUZHU GENERAL TECH INST CO LTD
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