Placental extract biological gel preparation for treating premature ovarian failure and preparation method thereof

A bio-gel, premature ovarian failure technology, applied in the biological field, can solve problems such as waste and affect product efficacy, and achieve the effect of treating premature ovarian failure, avoiding safety and immune rejection problems, and improving premature ovarian failure.

Active Publication Date: 2017-11-24
GUANGZHOU ZHUNYOU BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, the use of placenta is mostly in the form of oral administration, soup supplementation, capsules, freeze-dried powder, etc. However, due to the unique fishy smell of placenta, it will make users feel sick to a certain extent, and the way of taking it orally will affect it to a certain extent. The efficacy of the product is reduced, resulting in waste

Method used

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  • Placental extract biological gel preparation for treating premature ovarian failure and preparation method thereof
  • Placental extract biological gel preparation for treating premature ovarian failure and preparation method thereof

Examples

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Effect test

Embodiment 1

[0039] Embodiment 1 A kind of placenta extract biogel preparation

[0040] The placenta extract biogel preparation of this embodiment is prepared from placenta extract, carbomer, ethylparaben, propylene glycol, water-soluble azone, and triethanolamide. 98% of the volume of the gel preparation.

[0041] The preparation method of the placenta extract biogel preparation of the present embodiment comprises the following steps:

[0042] (1), select 100 mL of fresh healthy placenta tissue after selection;

[0043](2) Fully wash the placental tissue and cut it into small pieces, remove the blood vessels and mucosal tissue, put it in 100mL50mmoL / L acetic acid-sodium acetate buffer solution (pH4.0) for homogenization; place the homogenate at 4°C Incubate in a water bath for 2.5 hours, stirring occasionally during the period; after returning to room temperature, refrigerate and centrifuge (4°C, 6600r / min, 30min) to obtain a precipitate and about 150mL of supernatant;

[0044] (3), at...

Embodiment 2

[0051] Embodiment 2 A kind of placenta extract biogel preparation

[0052] The placenta extract biogel preparation of this example is prepared from placenta extract, gelatin, ethylparaben, propylene glycol, and water-soluble azone, and the volume of the placenta extract accounts for 95.2% of the volume of the biogel preparation.

[0053] The preparation method of the placenta extract biogel preparation of the present embodiment comprises the following steps:

[0054] Steps (1)-(7) are the same as in Example 1.

[0055] (8), take 12.6g of gelatin and add 100ml of placenta extract, and make water-hydrocolloid after fully swelling; take 0.15g of ethylparaben, dissolve it in 7.5ml of propylene glycol, and then add the solution to gelatin water -Add 0.75g of water-soluble azone to the hydrocolloid, then add the placenta extract to make up to 157.5ml, keep stirring until it forms a beige gel, and then divide it into gel tubes or capsules to obtain the desired preparation .

[005...

Embodiment 3

[0057] Embodiment 3 A kind of placenta extract biogel preparation

[0058] The placenta extract biogel preparation of this embodiment is prepared from placenta extract, sodium carboxymethylcellulose, ethylparaben, propylene glycol, water-soluble azone and aluminum chloride, and the volume of placenta extract accounts for 96.2% by volume of the biogel formulation.

[0059] The preparation method of the placenta extract biogel preparation of the present embodiment comprises the following steps:

[0060] Steps (1)-(7) are the same as in Example 1.

[0061] (8), get sodium carboxymethyl cellulose 3.12g, add 100ml placenta extract, make water-hydrocolloid after fully swelling; Get the ethylparaben of 0.45g, be dissolved in 6ml propylene glycol, then Add the solution to the sodium carboxymethylcellulose water-hydrocolloid, stir well, add 2.25g of water-soluble azone, then add the placenta extract to 156ml, add aluminum chloride drop by drop, and keep stirring until it turns beige ...

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Abstract

The invention discloses a placental extract biological gel preparation for treating premature ovarian failure and a preparation method thereof. The placental extract biological gel preparation is prepared from a gel substrate and placental extract serving as an active ingredient, wherein the volume of the placental extract is 90 to 99.5% of that of the biological gel preparation. According to the placental extract biological gel preparation disclosed by the invention, the placental extract is utilized as the active ingredient and obtained by being purified by multistep of technologies; not only are effective ingredients of collagen, polypeptide, varieties of growth factors and the like in placenta kept, but also no cell component is contained, and the problems of safety and immunological rejection of cell preparation are solved. The preparation is favorable for promoting ovarian function reconstruction of a premature ovarian failure patient, has a very good premature ovarian failure treating effect, avoids oral hormone therapy and hormone dependence, utilizes mucosa transdermal absorption playing action, can be fully absorbed, avoids injection and has better safety.

Description

technical field [0001] The invention belongs to the field of biotechnology, and more specifically, the invention relates to a placenta extract biogel preparation for treating premature ovarian failure and a preparation method thereof. Background technique [0002] Premature ovarian failure (POF) refers to a disease caused by various etiologies in which women under the age of 40 experience amenorrhea, decreased estrogen secretion, and increased gonadotropin levels due to ovarian failure. [0003] The incidence of POF is increasing year by year, and the proportion of POF in female infertility patients is also increasing year by year. The two major threats of POF to women's reproductive health are the decrease of estrogen level and the loss of fertility. The decrease of estrogen level increases the risk of osteoporosis and coronary heart disease in women. Women who are in the childbearing period have early amenorrhea and loss of fertility, which will lead to a series of psycho...

Claims

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Application Information

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IPC IPC(8): A61K35/50A61K9/06A61P15/08
CPCA61K9/06A61K35/50A61K47/42
Inventor 吴道贫李文禄赖小华陶然
Owner GUANGZHOU ZHUNYOU BIOLOGICAL TECH CO LTD
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