Methods for the assessment of dietary protein intake in patients with chronic kidney disease

Abstract

The invention discloses an evaluation method for diet protein intake (DPI) of a chronic kidney disease (CKD) patient. Through research of relationships between a fasting serum blood urea nitrogen / creatinine ratio (BUN / Cr) and a single-time urine urea nitrogen / creatinine ratio (UUN / Cr) of a CKD third-phase patient with a stable illness state, and the diet protein intake (DPI), a DPI simple calculation formula based on the fasting serum BUN / Cr and / or random urine UUN / Cr is established. According to the final calculation formula, it is expected that a traditional method for evaluating the DPI through subsistence of the urine within 24 hours can be replaced by a biochemical detection result of a single-time blood or urine in clinical follow-up. Defects such as complexity, long detection time, poor accuracy, difficult sample subsistence or low patient compliance in the traditional method are overcome. Clinically, the method can be used for clinical follow-up, simple blood drawing or single-time urination, thereby evaluating the DPI. The method can be used for managing the diet protein intake of the CKD patient well, fast and conveniently.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an evaluation method for dietary protein intake of patients with chronic kidney disease. Background technique [0002] The currently commonly used methods for evaluating dietary protein intake (DPI) mainly include dietary survey, 24-hour urine measurement of urea nitrogen, urea nitrogen expression rate, protein equivalent, and protein decomposition rate. Among them, 1) dietary survey: dietary survey as An important tool in nutrition research, most patients review their 24-hour diet or record their own diet for 3 to 7 days, and use the conversion of common food nutrients to calculate protein intake; this method requires experienced physicians or nutritionists. Time-consuming, highly subjective, and prone to errors. Some studies believe that this method tends to overestimate the patient’s real protein intake. Therefore, it is difficult for doctors to complete dietary s...

AI Technical Summary

Problems solved by technology

[0010] Among them: GU(mg / min)=Curea(ml / min)(BUN(mg / ml),Curea(ml / min)=[Uurea(mg / ml) / BUN(mg / ml)]×[urine output( ml) / time (min)] (Note: GU is urea generation rate; Curea is urea clearance rate; Uurea is urine urea nitrogen concentration; BUN is blood urea nitrogen); this formula calculates the relevant biochemical indicators that need to be detected simultaneously in blood and urine , because of too cumbersome clinical application is not common

[0011] In summary, the above-mentioned methods have shortcomings such as tediousness, long detection time, poor accuracy, difficulty in specimen collection, or poor patient compliance. At present, there is an urgent need for a method that can be used for outpatient follow-up, simple blood draw or single urination to estimate DPI. Methods

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